Tanaka, Tomoyuki

Professor

  • United Kingdom

20012022
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Personal profile

Research

Chromosome duplication and segregation in the cell division cycle

To maintain genetic integrity, eukaryotic cells must duplicate their chromosomes and then segregate them to their daughter cells with high fidelity during each cell division cycle. The unravelling of the mechanisms ensuring these processes should improve our understanding of various human diseases such as cancers and congenital disorders, which are characterized by chromosome instability and aneuploidy.

For our studies, we use budding yeast because of the amenable genetics and detailed proteomic information available for this organism. Overwhelming evidence suggests that the basic mechanisms of chromosome regulation are well conserved from yeast to humans. Budding yeast is therefore an excellent model organism for the study of chromosome duplication and segregation.

Fingerprint Dive into the research topics where Tomoyuki Tanaka is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 23 Similar Profiles
Kinetochores Medicine & Life Sciences
Microtubules Medicine & Life Sciences
Saccharomycetales Medicine & Life Sciences
Spindle Poles Medicine & Life Sciences
Spindle Apparatus Medicine & Life Sciences
Chromosomes Chemical Compounds
Centromere Medicine & Life Sciences
Spindle Pole Bodies Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2013 2022

Research Output 2001 2017

23 Downloads (Pure)

Mechanisms mitigating problems with multiple kinetochores on one microtubule in early mitosis

Yue, Z., Komoto, S., Gierlinski, M., Pasquali, D., Kitamura, E. & Tanaka, T. U., 15 Jul 2017, In : Journal of Cell Science. 130, 14, p. 2266-2276 11 p.

Research output: Contribution to journalArticle

Open Access
File
Kinetochores
Mitosis
Microtubules
Spindle Poles
Chromosome Segregation
5 Citations (Scopus)
19 Downloads (Pure)

Molecular mechanisms facilitating the initial kinetochore encounter with spindle microtubules

Vasileva, V., Gierlinski, M., Yue, Z., O'Reilly, N., Kitamura, E. & Tanaka, T. U., 26 Apr 2017, In : Journal of Cell Biology. 216, 6, p. 1809-1822 14 p.

Research output: Contribution to journalArticle

Open Access
File
Kinetochores
Microtubules
Saccharomycetales
Mitosis
5 Citations (Scopus)
32 Downloads (Pure)
Open Access
File
Anaphase
Chromatids
Acetylation
S Phase
Separase

Transport of intensity microscopy for distinguishing single and bundled microtubules

Tyrell Davis, Q., Tanaka, T. & McGloin, D., 2017, European Quantum Electronics Conference, EQEC 2017. Optical Society of America, Vol. Part F81-EQEC 2017. JSII_P_5

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)
79 Downloads (Pure)
Open Access
File
Cell Division
Chromatin
Genes
Workflow
Eukaryota

Thesis

Dissecting the role of Ndc80 and Dam1 complexes in tethering kinetochores at the microtubule plus end: an in vivo approach

Author: Kalantzaki, M., 2013

Supervisor: Tanaka, T. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

Kinetochore-derived Microtubules: from Molecular Regulation to their Role in Mitosis

Author: Vasileva, V., 2015

Supervisor: Tanaka, T. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

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