3D Monte Carlo radiation transfer modelling of photodynamic therapy

C. Louise Campbell, Craig Christison, C. Tom A Brown, Kenneth Wood, Ronan M. Valentine, Harry Moseley

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    2 Citations (Scopus)

    Abstract

    The effects of ageing and skin type on Photodynamic Therapy (PDT) for different treatment methods have been theoretically investigated. A multilayered Monte Carlo Radiation Transfer model is presented where both daylight activated PDT and conventional PDT are compared. It was found that light penetrates deeper through older skin with a lighter complexion, which translates into a deeper effective treatment depth. The effect of ageing was found to be larger for darker skin types. The investigation further strengthens the usage of daylight as a potential light source for PDT where effective treatment depths of about 2 mm can be achieved.

    Original languageEnglish
    Title of host publicationBiophotonics South America
    EditorsCristina Kurachi, Katarina Svanberg, Bruce J. Tromberg, Vanderlei S. Bagnato
    Place of PublicationBellingham
    PublisherSPIE-International Society for Optical Engineering
    ISBN (Print)9781628416961
    DOIs
    Publication statusPublished - 2015
    EventSPIE Biophotonics South America 2015 - Copacabana Palace Hotel, Rio de Janeiro, Brazil
    Duration: 23 May 201525 May 2015
    http://spie.org/x113829.xml

    Publication series

    NameProceedings of SPIE
    PublisherSPIE
    Volume9531
    NameProgress in biomedical optics and imaging
    PublisherSPIE
    Number52
    Volume16

    Conference

    ConferenceSPIE Biophotonics South America 2015
    CountryBrazil
    CityRio de Janeiro
    Period23/05/1525/05/15
    Internet address

    Fingerprint

    Photodynamic therapy
    Photochemotherapy
    therapy
    Radiation
    Skin
    radiation
    Aging of materials
    Skin Aging
    Light
    Light sources
    light sources
    Therapeutics

    Keywords

    • Daylight activated photodynamic therapy
    • Monte Carlo radiation Transfer modelling of Photodynamic Therapy
    • Skin ageing
    • Theoretical investigation of Photodynamic therapy
    • Tissue optics

    Cite this

    Campbell, C. L., Christison, C., Brown, C. T. A., Wood, K., Valentine, R. M., & Moseley, H. (2015). 3D Monte Carlo radiation transfer modelling of photodynamic therapy. In C. Kurachi, K. Svanberg, B. J. Tromberg, & V. S. Bagnato (Eds.), Biophotonics South America [95311H] (Proceedings of SPIE; Vol. 9531), (Progress in biomedical optics and imaging; Vol. 16, No. 52). Bellingham: SPIE-International Society for Optical Engineering. https://doi.org/10.1117/12.2180744
    Campbell, C. Louise ; Christison, Craig ; Brown, C. Tom A ; Wood, Kenneth ; Valentine, Ronan M. ; Moseley, Harry. / 3D Monte Carlo radiation transfer modelling of photodynamic therapy. Biophotonics South America. editor / Cristina Kurachi ; Katarina Svanberg ; Bruce J. Tromberg ; Vanderlei S. Bagnato. Bellingham : SPIE-International Society for Optical Engineering, 2015. (Proceedings of SPIE). (Progress in biomedical optics and imaging; 52).
    @inproceedings{bd5b6de59fd546b6b05101f83cae5c2f,
    title = "3D Monte Carlo radiation transfer modelling of photodynamic therapy",
    abstract = "The effects of ageing and skin type on Photodynamic Therapy (PDT) for different treatment methods have been theoretically investigated. A multilayered Monte Carlo Radiation Transfer model is presented where both daylight activated PDT and conventional PDT are compared. It was found that light penetrates deeper through older skin with a lighter complexion, which translates into a deeper effective treatment depth. The effect of ageing was found to be larger for darker skin types. The investigation further strengthens the usage of daylight as a potential light source for PDT where effective treatment depths of about 2 mm can be achieved.",
    keywords = "Daylight activated photodynamic therapy, Monte Carlo radiation Transfer modelling of Photodynamic Therapy, Skin ageing, Theoretical investigation of Photodynamic therapy, Tissue optics",
    author = "Campbell, {C. Louise} and Craig Christison and Brown, {C. Tom A} and Kenneth Wood and Valentine, {Ronan M.} and Harry Moseley",
    year = "2015",
    doi = "10.1117/12.2180744",
    language = "English",
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    series = "Proceedings of SPIE",
    publisher = "SPIE-International Society for Optical Engineering",
    editor = "Kurachi, {Cristina } and Svanberg, {Katarina } and Tromberg, {Bruce J. } and Bagnato, {Vanderlei S. }",
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    Campbell, CL, Christison, C, Brown, CTA, Wood, K, Valentine, RM & Moseley, H 2015, 3D Monte Carlo radiation transfer modelling of photodynamic therapy. in C Kurachi, K Svanberg, BJ Tromberg & VS Bagnato (eds), Biophotonics South America., 95311H, Proceedings of SPIE, vol. 9531, Progress in biomedical optics and imaging, no. 52, vol. 16, SPIE-International Society for Optical Engineering, Bellingham, SPIE Biophotonics South America 2015, Rio de Janeiro, Brazil, 23/05/15. https://doi.org/10.1117/12.2180744

    3D Monte Carlo radiation transfer modelling of photodynamic therapy. / Campbell, C. Louise; Christison, Craig; Brown, C. Tom A; Wood, Kenneth; Valentine, Ronan M.; Moseley, Harry.

    Biophotonics South America. ed. / Cristina Kurachi; Katarina Svanberg; Bruce J. Tromberg; Vanderlei S. Bagnato. Bellingham : SPIE-International Society for Optical Engineering, 2015. 95311H (Proceedings of SPIE; Vol. 9531), (Progress in biomedical optics and imaging; Vol. 16, No. 52).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    TY - GEN

    T1 - 3D Monte Carlo radiation transfer modelling of photodynamic therapy

    AU - Campbell, C. Louise

    AU - Christison, Craig

    AU - Brown, C. Tom A

    AU - Wood, Kenneth

    AU - Valentine, Ronan M.

    AU - Moseley, Harry

    PY - 2015

    Y1 - 2015

    N2 - The effects of ageing and skin type on Photodynamic Therapy (PDT) for different treatment methods have been theoretically investigated. A multilayered Monte Carlo Radiation Transfer model is presented where both daylight activated PDT and conventional PDT are compared. It was found that light penetrates deeper through older skin with a lighter complexion, which translates into a deeper effective treatment depth. The effect of ageing was found to be larger for darker skin types. The investigation further strengthens the usage of daylight as a potential light source for PDT where effective treatment depths of about 2 mm can be achieved.

    AB - The effects of ageing and skin type on Photodynamic Therapy (PDT) for different treatment methods have been theoretically investigated. A multilayered Monte Carlo Radiation Transfer model is presented where both daylight activated PDT and conventional PDT are compared. It was found that light penetrates deeper through older skin with a lighter complexion, which translates into a deeper effective treatment depth. The effect of ageing was found to be larger for darker skin types. The investigation further strengthens the usage of daylight as a potential light source for PDT where effective treatment depths of about 2 mm can be achieved.

    KW - Daylight activated photodynamic therapy

    KW - Monte Carlo radiation Transfer modelling of Photodynamic Therapy

    KW - Skin ageing

    KW - Theoretical investigation of Photodynamic therapy

    KW - Tissue optics

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    DO - 10.1117/12.2180744

    M3 - Conference contribution

    AN - SCOPUS:84938942933

    SN - 9781628416961

    T3 - Proceedings of SPIE

    BT - Biophotonics South America

    A2 - Kurachi, Cristina

    A2 - Svanberg, Katarina

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    PB - SPIE-International Society for Optical Engineering

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    Campbell CL, Christison C, Brown CTA, Wood K, Valentine RM, Moseley H. 3D Monte Carlo radiation transfer modelling of photodynamic therapy. In Kurachi C, Svanberg K, Tromberg BJ, Bagnato VS, editors, Biophotonics South America. Bellingham: SPIE-International Society for Optical Engineering. 2015. 95311H. (Proceedings of SPIE). (Progress in biomedical optics and imaging; 52). https://doi.org/10.1117/12.2180744