Application of optical trapping for cavitation studies

P. A. Prentice, P. A. Campbell

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    1 Citation (Scopus)

    Abstract

    This study has observed microscopic level cavitation processes in shelled second generation ultrasound contrast agent microbubbles. The spatial and temporal resolutions required for this undertaking have been achieved via a unique hybridisation of optical trapping with ultra high speed microphotography. Upon insonation with ultrasound in the region of 0.5-4MPa, microjets were observed to develop within, and subsequently issue from, cavitating bubbles. Jet impact into target substrates, including monolayers of biological cells, was observed. These observations provide direct evidence for the involvement of microjetting events during ultrasound exposure on live cells, a process that may have future potential as a novel non-invasive route to drug- and gene-based therapies.

    Original languageEnglish
    Title of host publicationOptical Trapping and Optical Micromanipulation V
    EditorsKishan Dholakia, Gabriel C. Spalding
    Place of PublicationBellingham
    PublisherSPIE-International Society for Optical Engineering
    Number of pages8
    ISBN (Print)9780819472588
    DOIs
    Publication statusPublished - 2008
    EventSPIE Optics+Photonics 2008: Optical Trapping and Optical Micromanipulation V - San Diego Convention Center, San Diego, United States
    Duration: 10 Aug 200813 Aug 2008
    http://spie.org/x27421.xml

    Publication series

    NameProceedings of SPIE
    PublisherSPIE
    Volume7038

    Conference

    ConferenceSPIE Optics+Photonics 2008: Optical Trapping and Optical Micromanipulation V
    Abbreviated titlehttp://spie.org/x27421.xml
    CountryUnited States
    CitySan Diego
    Period10/08/0813/08/08
    Internet address

    Keywords

    • Optical trapping
    • microbubbles
    • acoustic cavitation
    • ultrasound
    • drug delivery
    • CONTRAST AGENTS
    • BUBBLE COLLAPSE
    • GENE-TRANSFER
    • CELL-LYSIS
    • IN-VIVO
    • ULTRASOUND
    • LASER
    • TRANSFECTION
    • BOUNDARIES
    • PRESSURES

    Cite this

    Prentice, P. A., & Campbell, P. A. (2008). Application of optical trapping for cavitation studies. In K. Dholakia, & G. C. Spalding (Eds.), Optical Trapping and Optical Micromanipulation V [70381N ] (Proceedings of SPIE; Vol. 7038). Bellingham: SPIE-International Society for Optical Engineering. https://doi.org/10.1117/12.794192
    Prentice, P. A. ; Campbell, P. A. / Application of optical trapping for cavitation studies. Optical Trapping and Optical Micromanipulation V. editor / Kishan Dholakia ; Gabriel C. Spalding. Bellingham : SPIE-International Society for Optical Engineering, 2008. (Proceedings of SPIE).
    @inproceedings{b086f68a8f3943c3881422d93d5571d8,
    title = "Application of optical trapping for cavitation studies",
    abstract = "This study has observed microscopic level cavitation processes in shelled second generation ultrasound contrast agent microbubbles. The spatial and temporal resolutions required for this undertaking have been achieved via a unique hybridisation of optical trapping with ultra high speed microphotography. Upon insonation with ultrasound in the region of 0.5-4MPa, microjets were observed to develop within, and subsequently issue from, cavitating bubbles. Jet impact into target substrates, including monolayers of biological cells, was observed. These observations provide direct evidence for the involvement of microjetting events during ultrasound exposure on live cells, a process that may have future potential as a novel non-invasive route to drug- and gene-based therapies.",
    keywords = "Optical trapping, microbubbles, acoustic cavitation, ultrasound, drug delivery, CONTRAST AGENTS, BUBBLE COLLAPSE, GENE-TRANSFER, CELL-LYSIS, IN-VIVO, ULTRASOUND, LASER, TRANSFECTION, BOUNDARIES, PRESSURES",
    author = "Prentice, {P. A.} and Campbell, {P. A.}",
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    isbn = "9780819472588",
    series = "Proceedings of SPIE",
    publisher = "SPIE-International Society for Optical Engineering",
    editor = "Kishan Dholakia and Spalding, {Gabriel C.}",
    booktitle = "Optical Trapping and Optical Micromanipulation V",

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    Prentice, PA & Campbell, PA 2008, Application of optical trapping for cavitation studies. in K Dholakia & GC Spalding (eds), Optical Trapping and Optical Micromanipulation V., 70381N , Proceedings of SPIE, vol. 7038, SPIE-International Society for Optical Engineering, Bellingham, SPIE Optics+Photonics 2008: Optical Trapping and Optical Micromanipulation V, San Diego, United States, 10/08/08. https://doi.org/10.1117/12.794192

    Application of optical trapping for cavitation studies. / Prentice, P. A.; Campbell, P. A.

    Optical Trapping and Optical Micromanipulation V. ed. / Kishan Dholakia; Gabriel C. Spalding. Bellingham : SPIE-International Society for Optical Engineering, 2008. 70381N (Proceedings of SPIE; Vol. 7038).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    TY - GEN

    T1 - Application of optical trapping for cavitation studies

    AU - Prentice, P. A.

    AU - Campbell, P. A.

    PY - 2008

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    N2 - This study has observed microscopic level cavitation processes in shelled second generation ultrasound contrast agent microbubbles. The spatial and temporal resolutions required for this undertaking have been achieved via a unique hybridisation of optical trapping with ultra high speed microphotography. Upon insonation with ultrasound in the region of 0.5-4MPa, microjets were observed to develop within, and subsequently issue from, cavitating bubbles. Jet impact into target substrates, including monolayers of biological cells, was observed. These observations provide direct evidence for the involvement of microjetting events during ultrasound exposure on live cells, a process that may have future potential as a novel non-invasive route to drug- and gene-based therapies.

    AB - This study has observed microscopic level cavitation processes in shelled second generation ultrasound contrast agent microbubbles. The spatial and temporal resolutions required for this undertaking have been achieved via a unique hybridisation of optical trapping with ultra high speed microphotography. Upon insonation with ultrasound in the region of 0.5-4MPa, microjets were observed to develop within, and subsequently issue from, cavitating bubbles. Jet impact into target substrates, including monolayers of biological cells, was observed. These observations provide direct evidence for the involvement of microjetting events during ultrasound exposure on live cells, a process that may have future potential as a novel non-invasive route to drug- and gene-based therapies.

    KW - Optical trapping

    KW - microbubbles

    KW - acoustic cavitation

    KW - ultrasound

    KW - drug delivery

    KW - CONTRAST AGENTS

    KW - BUBBLE COLLAPSE

    KW - GENE-TRANSFER

    KW - CELL-LYSIS

    KW - IN-VIVO

    KW - ULTRASOUND

    KW - LASER

    KW - TRANSFECTION

    KW - BOUNDARIES

    KW - PRESSURES

    U2 - 10.1117/12.794192

    DO - 10.1117/12.794192

    M3 - Conference contribution

    SN - 9780819472588

    T3 - Proceedings of SPIE

    BT - Optical Trapping and Optical Micromanipulation V

    A2 - Dholakia, Kishan

    A2 - Spalding, Gabriel C.

    PB - SPIE-International Society for Optical Engineering

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    Prentice PA, Campbell PA. Application of optical trapping for cavitation studies. In Dholakia K, Spalding GC, editors, Optical Trapping and Optical Micromanipulation V. Bellingham: SPIE-International Society for Optical Engineering. 2008. 70381N . (Proceedings of SPIE). https://doi.org/10.1117/12.794192