Between- and within-scanner variability in the CaliBrain study n-back cognitive task

Victoria Gradin, Viktoria-Eleni Gountouna, Gordon Waiter, Trevor S. Ahearn, David Brennan, Barrie Condon, Ian Marshall, David J. McGonigle, Alison D. Murray, Heather Whalley, Jonathan Cavanagh, Donald Hadley, Katherine Lymer, Andrew McIntosh, Thomas William Moorhead, Dominic Job, Joanna Wardlaw, Stephen M. Lawrie, John Douglas Steele

    Research output: Contribution to journalArticle

    17 Citations (Scopus)

    Abstract

    Psychiatric neuroimaging techniques are likely to improve understanding of the brain in health and disease, but studies tend to be small, based in one imaging centre and of unclear generalisability. Multicentre studies have great appeal but face problems if functional magnetic resonance imaging (fMRI) data from different centres are to be combined. Fourteen healthy volunteers had two brain scans on different days at three scanners. Considerable effort was first made to use similar scanning sequences and standardise task implementation across centres. The n-back cognitive task was used to investigate between- and within-scanner reproducibility and reliability. Both the functional imaging and behavioural results were in good accord with the existing literature. We found no significant differences in the activation/deactivation maps between scanners, or between repeat visits to the same scanners. Between- and within-scanner reproducibility and reliability was very similar. However, the smoothness of images from the scanners differed, suggesting that smoothness equalization might further reduce inter-scanner variability. Our results for the n-back task suggest it is possible to acquire fMRI data from different scanners which allows pooling across centres, when the same field strength scanners are used and scanning sequences and paradigm implementations are standardised. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)86-95
    Number of pages10
    JournalPsychiatry Research: Neuroimaging
    Volume184
    Issue number2
    DOIs
    Publication statusPublished - 30 Nov 2010

    Keywords

    • Multi-centre fMRI
    • Reproducibility
    • Reliability
    • FALSE DISCOVERY RATE
    • WORKING-MEMORY TASK
    • MULTICENTER FMRI
    • BRAIN ACTIVITY
    • MOTOR TASK
    • REPRODUCIBILITY
    • SCHIZOPHRENIA
    • RELIABILITY
    • PERFORMANCE
    • ACTIVATION

    Cite this

    Gradin, Victoria ; Gountouna, Viktoria-Eleni ; Waiter, Gordon ; Ahearn, Trevor S. ; Brennan, David ; Condon, Barrie ; Marshall, Ian ; McGonigle, David J. ; Murray, Alison D. ; Whalley, Heather ; Cavanagh, Jonathan ; Hadley, Donald ; Lymer, Katherine ; McIntosh, Andrew ; Moorhead, Thomas William ; Job, Dominic ; Wardlaw, Joanna ; Lawrie, Stephen M. ; Steele, John Douglas. / Between- and within-scanner variability in the CaliBrain study n-back cognitive task. In: Psychiatry Research: Neuroimaging. 2010 ; Vol. 184, No. 2. pp. 86-95.
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    abstract = "Psychiatric neuroimaging techniques are likely to improve understanding of the brain in health and disease, but studies tend to be small, based in one imaging centre and of unclear generalisability. Multicentre studies have great appeal but face problems if functional magnetic resonance imaging (fMRI) data from different centres are to be combined. Fourteen healthy volunteers had two brain scans on different days at three scanners. Considerable effort was first made to use similar scanning sequences and standardise task implementation across centres. The n-back cognitive task was used to investigate between- and within-scanner reproducibility and reliability. Both the functional imaging and behavioural results were in good accord with the existing literature. We found no significant differences in the activation/deactivation maps between scanners, or between repeat visits to the same scanners. Between- and within-scanner reproducibility and reliability was very similar. However, the smoothness of images from the scanners differed, suggesting that smoothness equalization might further reduce inter-scanner variability. Our results for the n-back task suggest it is possible to acquire fMRI data from different scanners which allows pooling across centres, when the same field strength scanners are used and scanning sequences and paradigm implementations are standardised. (C) 2010 Elsevier Ireland Ltd. All rights reserved.",
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    Gradin, V, Gountouna, V-E, Waiter, G, Ahearn, TS, Brennan, D, Condon, B, Marshall, I, McGonigle, DJ, Murray, AD, Whalley, H, Cavanagh, J, Hadley, D, Lymer, K, McIntosh, A, Moorhead, TW, Job, D, Wardlaw, J, Lawrie, SM & Steele, JD 2010, 'Between- and within-scanner variability in the CaliBrain study n-back cognitive task', Psychiatry Research: Neuroimaging, vol. 184, no. 2, pp. 86-95. https://doi.org/10.1016/j.pscychresns.2010.08.010

    Between- and within-scanner variability in the CaliBrain study n-back cognitive task. / Gradin, Victoria; Gountouna, Viktoria-Eleni; Waiter, Gordon; Ahearn, Trevor S.; Brennan, David; Condon, Barrie; Marshall, Ian; McGonigle, David J.; Murray, Alison D.; Whalley, Heather; Cavanagh, Jonathan; Hadley, Donald; Lymer, Katherine; McIntosh, Andrew; Moorhead, Thomas William; Job, Dominic; Wardlaw, Joanna; Lawrie, Stephen M.; Steele, John Douglas.

    In: Psychiatry Research: Neuroimaging, Vol. 184, No. 2, 30.11.2010, p. 86-95.

    Research output: Contribution to journalArticle

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    AU - Gradin, Victoria

    AU - Gountouna, Viktoria-Eleni

    AU - Waiter, Gordon

    AU - Ahearn, Trevor S.

    AU - Brennan, David

    AU - Condon, Barrie

    AU - Marshall, Ian

    AU - McGonigle, David J.

    AU - Murray, Alison D.

    AU - Whalley, Heather

    AU - Cavanagh, Jonathan

    AU - Hadley, Donald

    AU - Lymer, Katherine

    AU - McIntosh, Andrew

    AU - Moorhead, Thomas William

    AU - Job, Dominic

    AU - Wardlaw, Joanna

    AU - Lawrie, Stephen M.

    AU - Steele, John Douglas

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    N2 - Psychiatric neuroimaging techniques are likely to improve understanding of the brain in health and disease, but studies tend to be small, based in one imaging centre and of unclear generalisability. Multicentre studies have great appeal but face problems if functional magnetic resonance imaging (fMRI) data from different centres are to be combined. Fourteen healthy volunteers had two brain scans on different days at three scanners. Considerable effort was first made to use similar scanning sequences and standardise task implementation across centres. The n-back cognitive task was used to investigate between- and within-scanner reproducibility and reliability. Both the functional imaging and behavioural results were in good accord with the existing literature. We found no significant differences in the activation/deactivation maps between scanners, or between repeat visits to the same scanners. Between- and within-scanner reproducibility and reliability was very similar. However, the smoothness of images from the scanners differed, suggesting that smoothness equalization might further reduce inter-scanner variability. Our results for the n-back task suggest it is possible to acquire fMRI data from different scanners which allows pooling across centres, when the same field strength scanners are used and scanning sequences and paradigm implementations are standardised. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

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    KW - Multi-centre fMRI

    KW - Reproducibility

    KW - Reliability

    KW - FALSE DISCOVERY RATE

    KW - WORKING-MEMORY TASK

    KW - MULTICENTER FMRI

    KW - BRAIN ACTIVITY

    KW - MOTOR TASK

    KW - REPRODUCIBILITY

    KW - SCHIZOPHRENIA

    KW - RELIABILITY

    KW - PERFORMANCE

    KW - ACTIVATION

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    JF - Psychiatry Research: Neuroimaging

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