Bile reflux in columnar-lined Barrett's oesophagus

S. Y. Iftikhar, S. Ledingham, R. J. Steele, D. F. Evans, K. Lendrum, M. Atkinson, J. D. Hardcastle

    Research output: Contribution to journalArticle

    65 Citations (Scopus)

    Abstract

    Total and individual bile acid concentrations in the oesophageal aspirates from 30 patients with Barrett's oesophagus were compared with those from 15 patients with oesophagitis and 15 normal subjects. The highest total bile acid concentrations were found in the Barrett's patients and this was statistically significant when compared with controls but not oesophagitis patients. However, when the 95th percentile value of bile acid concentration in the normal subjects was taken as the 'cut-off' level, a significantly higher number of Barrett's patients (15/30) were bile refluxers than were the oesophagitis patients (3/15). Glycocholic and taurocholic acids were the predominant bile acids detected, but taurochenodeoxycholic acid was also present in significant amounts in the patients with oesophagitis. It is possible that bile reflux contributes to the development of Barrett's oesophagus.
    Original languageEnglish
    Pages (from-to)411-6
    Number of pages6
    JournalAnnals of the Royal College of Surgeons of England
    Volume75
    Issue number6
    Publication statusPublished - Nov 1993

    Fingerprint

    Bile Reflux
    Barrett Esophagus
    Esophagitis
    Bile Acids and Salts
    Taurochenodeoxycholic Acid
    Glycocholic Acid
    Taurocholic Acid
    Bile

    Keywords

    • Aged
    • Barrett Esophagus
    • Bile Acids and Salts
    • Eating
    • Female
    • Gastroesophageal Reflux
    • Glycocholic Acid
    • Humans
    • Male
    • Middle Aged
    • Posture
    • Taurocholic Acid

    Cite this

    Iftikhar, S. Y., Ledingham, S., Steele, R. J., Evans, D. F., Lendrum, K., Atkinson, M., & Hardcastle, J. D. (1993). Bile reflux in columnar-lined Barrett's oesophagus. Annals of the Royal College of Surgeons of England, 75(6), 411-6.
    Iftikhar, S. Y. ; Ledingham, S. ; Steele, R. J. ; Evans, D. F. ; Lendrum, K. ; Atkinson, M. ; Hardcastle, J. D. / Bile reflux in columnar-lined Barrett's oesophagus. In: Annals of the Royal College of Surgeons of England. 1993 ; Vol. 75, No. 6. pp. 411-6.
    @article{4df70e61f2114597b9d3cbca3af4174b,
    title = "Bile reflux in columnar-lined Barrett's oesophagus",
    abstract = "Total and individual bile acid concentrations in the oesophageal aspirates from 30 patients with Barrett's oesophagus were compared with those from 15 patients with oesophagitis and 15 normal subjects. The highest total bile acid concentrations were found in the Barrett's patients and this was statistically significant when compared with controls but not oesophagitis patients. However, when the 95th percentile value of bile acid concentration in the normal subjects was taken as the 'cut-off' level, a significantly higher number of Barrett's patients (15/30) were bile refluxers than were the oesophagitis patients (3/15). Glycocholic and taurocholic acids were the predominant bile acids detected, but taurochenodeoxycholic acid was also present in significant amounts in the patients with oesophagitis. It is possible that bile reflux contributes to the development of Barrett's oesophagus.",
    keywords = "Aged, Barrett Esophagus, Bile Acids and Salts, Eating, Female, Gastroesophageal Reflux, Glycocholic Acid, Humans, Male, Middle Aged, Posture, Taurocholic Acid",
    author = "Iftikhar, {S. Y.} and S. Ledingham and Steele, {R. J.} and Evans, {D. F.} and K. Lendrum and M. Atkinson and Hardcastle, {J. D.}",
    year = "1993",
    month = "11",
    language = "English",
    volume = "75",
    pages = "411--6",
    journal = "Annals of the Royal College of Surgeons of England",
    issn = "0035-8843",
    publisher = "Royal College of Surgeons of England",
    number = "6",

    }

    Iftikhar, SY, Ledingham, S, Steele, RJ, Evans, DF, Lendrum, K, Atkinson, M & Hardcastle, JD 1993, 'Bile reflux in columnar-lined Barrett's oesophagus', Annals of the Royal College of Surgeons of England, vol. 75, no. 6, pp. 411-6.

    Bile reflux in columnar-lined Barrett's oesophagus. / Iftikhar, S. Y.; Ledingham, S.; Steele, R. J.; Evans, D. F.; Lendrum, K.; Atkinson, M.; Hardcastle, J. D.

    In: Annals of the Royal College of Surgeons of England, Vol. 75, No. 6, 11.1993, p. 411-6.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Bile reflux in columnar-lined Barrett's oesophagus

    AU - Iftikhar, S. Y.

    AU - Ledingham, S.

    AU - Steele, R. J.

    AU - Evans, D. F.

    AU - Lendrum, K.

    AU - Atkinson, M.

    AU - Hardcastle, J. D.

    PY - 1993/11

    Y1 - 1993/11

    N2 - Total and individual bile acid concentrations in the oesophageal aspirates from 30 patients with Barrett's oesophagus were compared with those from 15 patients with oesophagitis and 15 normal subjects. The highest total bile acid concentrations were found in the Barrett's patients and this was statistically significant when compared with controls but not oesophagitis patients. However, when the 95th percentile value of bile acid concentration in the normal subjects was taken as the 'cut-off' level, a significantly higher number of Barrett's patients (15/30) were bile refluxers than were the oesophagitis patients (3/15). Glycocholic and taurocholic acids were the predominant bile acids detected, but taurochenodeoxycholic acid was also present in significant amounts in the patients with oesophagitis. It is possible that bile reflux contributes to the development of Barrett's oesophagus.

    AB - Total and individual bile acid concentrations in the oesophageal aspirates from 30 patients with Barrett's oesophagus were compared with those from 15 patients with oesophagitis and 15 normal subjects. The highest total bile acid concentrations were found in the Barrett's patients and this was statistically significant when compared with controls but not oesophagitis patients. However, when the 95th percentile value of bile acid concentration in the normal subjects was taken as the 'cut-off' level, a significantly higher number of Barrett's patients (15/30) were bile refluxers than were the oesophagitis patients (3/15). Glycocholic and taurocholic acids were the predominant bile acids detected, but taurochenodeoxycholic acid was also present in significant amounts in the patients with oesophagitis. It is possible that bile reflux contributes to the development of Barrett's oesophagus.

    KW - Aged

    KW - Barrett Esophagus

    KW - Bile Acids and Salts

    KW - Eating

    KW - Female

    KW - Gastroesophageal Reflux

    KW - Glycocholic Acid

    KW - Humans

    KW - Male

    KW - Middle Aged

    KW - Posture

    KW - Taurocholic Acid

    M3 - Article

    C2 - 8285543

    VL - 75

    SP - 411

    EP - 416

    JO - Annals of the Royal College of Surgeons of England

    JF - Annals of the Royal College of Surgeons of England

    SN - 0035-8843

    IS - 6

    ER -

    Iftikhar SY, Ledingham S, Steele RJ, Evans DF, Lendrum K, Atkinson M et al. Bile reflux in columnar-lined Barrett's oesophagus. Annals of the Royal College of Surgeons of England. 1993 Nov;75(6):411-6.