Cancer-induced bone pain

Lesley A. Colvin, Marie T. Fallon

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Bone is the third most common site of metastatic disease, after liver and lung, with approximately 75% of these patients suffering from related pain. Cancer-induced bone pain (CIBP) is a major clinical problem, with limited options for predictable, rapid, and effective treatment for some of the elements without unacceptable adverse effects. Our understanding of how current therapy acts is based mainly on studies in non-cancer pain syndromes, which are likely to be quite different, not only in clinical presentation, but also in terms of pathophysiology. It can be difficult to study the specific neurobiological changes associated with CIBP, although development of laboratory models of isolated bone metastases has allowed more specific study of pain mechanisms in this syndrome. In order to evaluate our current therapies properly and direct the development of new therapies logically, it is important to understand the underlying mechanisms of CIBP. This chapter discusses pain processing and the mechanisms and management of CIBP.
Original languageEnglish
Title of host publicationOxford Textbook of Palliative Medicine
EditorsNathan Cherny, Marie Fallon, Stein Kaasa, Russell K. Portenoy, David C. Currow
Place of PublicationOxford
PublisherOxford University Press
Pages841-859
Number of pages19
Edition5
ISBN (Print)9780199656097
DOIs
Publication statusPublished - Mar 2015

Fingerprint

Bone Neoplasms
Pain
Bone and Bones
Therapeutics
Lung Diseases
Liver Diseases
Neoplasm Metastasis

Cite this

Colvin, L. A., & Fallon, M. T. (2015). Cancer-induced bone pain. In N. Cherny, M. Fallon, S. Kaasa, R. K. Portenoy, & D. C. Currow (Eds.), Oxford Textbook of Palliative Medicine (5 ed., pp. 841-859). Oxford: Oxford University Press. https://doi.org/10.1093/med/9780199656097.003.0132
Colvin, Lesley A. ; Fallon, Marie T. / Cancer-induced bone pain. Oxford Textbook of Palliative Medicine. editor / Nathan Cherny ; Marie Fallon ; Stein Kaasa ; Russell K. Portenoy ; David C. Currow. 5. ed. Oxford : Oxford University Press, 2015. pp. 841-859
@inbook{f28a222fbcee4038b6818ca9221bce19,
title = "Cancer-induced bone pain",
abstract = "Bone is the third most common site of metastatic disease, after liver and lung, with approximately 75{\%} of these patients suffering from related pain. Cancer-induced bone pain (CIBP) is a major clinical problem, with limited options for predictable, rapid, and effective treatment for some of the elements without unacceptable adverse effects. Our understanding of how current therapy acts is based mainly on studies in non-cancer pain syndromes, which are likely to be quite different, not only in clinical presentation, but also in terms of pathophysiology. It can be difficult to study the specific neurobiological changes associated with CIBP, although development of laboratory models of isolated bone metastases has allowed more specific study of pain mechanisms in this syndrome. In order to evaluate our current therapies properly and direct the development of new therapies logically, it is important to understand the underlying mechanisms of CIBP. This chapter discusses pain processing and the mechanisms and management of CIBP.",
author = "Colvin, {Lesley A.} and Fallon, {Marie T.}",
year = "2015",
month = "3",
doi = "10.1093/med/9780199656097.003.0132",
language = "English",
isbn = "9780199656097",
pages = "841--859",
editor = "Nathan Cherny and Marie Fallon and Stein Kaasa and Portenoy, {Russell K.} and Currow, {David C.}",
booktitle = "Oxford Textbook of Palliative Medicine",
publisher = "Oxford University Press",
address = "United Kingdom",
edition = "5",

}

Colvin, LA & Fallon, MT 2015, Cancer-induced bone pain. in N Cherny, M Fallon, S Kaasa, RK Portenoy & DC Currow (eds), Oxford Textbook of Palliative Medicine. 5 edn, Oxford University Press, Oxford, pp. 841-859. https://doi.org/10.1093/med/9780199656097.003.0132

Cancer-induced bone pain. / Colvin, Lesley A.; Fallon, Marie T.

Oxford Textbook of Palliative Medicine. ed. / Nathan Cherny; Marie Fallon; Stein Kaasa; Russell K. Portenoy; David C. Currow. 5. ed. Oxford : Oxford University Press, 2015. p. 841-859.

Research output: Chapter in Book/Report/Conference proceedingChapter

TY - CHAP

T1 - Cancer-induced bone pain

AU - Colvin, Lesley A.

AU - Fallon, Marie T.

PY - 2015/3

Y1 - 2015/3

N2 - Bone is the third most common site of metastatic disease, after liver and lung, with approximately 75% of these patients suffering from related pain. Cancer-induced bone pain (CIBP) is a major clinical problem, with limited options for predictable, rapid, and effective treatment for some of the elements without unacceptable adverse effects. Our understanding of how current therapy acts is based mainly on studies in non-cancer pain syndromes, which are likely to be quite different, not only in clinical presentation, but also in terms of pathophysiology. It can be difficult to study the specific neurobiological changes associated with CIBP, although development of laboratory models of isolated bone metastases has allowed more specific study of pain mechanisms in this syndrome. In order to evaluate our current therapies properly and direct the development of new therapies logically, it is important to understand the underlying mechanisms of CIBP. This chapter discusses pain processing and the mechanisms and management of CIBP.

AB - Bone is the third most common site of metastatic disease, after liver and lung, with approximately 75% of these patients suffering from related pain. Cancer-induced bone pain (CIBP) is a major clinical problem, with limited options for predictable, rapid, and effective treatment for some of the elements without unacceptable adverse effects. Our understanding of how current therapy acts is based mainly on studies in non-cancer pain syndromes, which are likely to be quite different, not only in clinical presentation, but also in terms of pathophysiology. It can be difficult to study the specific neurobiological changes associated with CIBP, although development of laboratory models of isolated bone metastases has allowed more specific study of pain mechanisms in this syndrome. In order to evaluate our current therapies properly and direct the development of new therapies logically, it is important to understand the underlying mechanisms of CIBP. This chapter discusses pain processing and the mechanisms and management of CIBP.

U2 - 10.1093/med/9780199656097.003.0132

DO - 10.1093/med/9780199656097.003.0132

M3 - Chapter

SN - 9780199656097

SP - 841

EP - 859

BT - Oxford Textbook of Palliative Medicine

A2 - Cherny, Nathan

A2 - Fallon, Marie

A2 - Kaasa, Stein

A2 - Portenoy, Russell K.

A2 - Currow, David C.

PB - Oxford University Press

CY - Oxford

ER -

Colvin LA, Fallon MT. Cancer-induced bone pain. In Cherny N, Fallon M, Kaasa S, Portenoy RK, Currow DC, editors, Oxford Textbook of Palliative Medicine. 5 ed. Oxford: Oxford University Press. 2015. p. 841-859 https://doi.org/10.1093/med/9780199656097.003.0132