Coibamide A Induces mTOR-Independent Autophagy and Cell Death in Human Glioblastoma Cells

Andrew M. Hau, Jeffrey A. Greenwood, Christiane V. Loehr, Jeffrey D. Serrill, Philip J. Proteau, Ian G. Ganley, Kerry L. McPhail, Jane E. Ishmael

    Research output: Contribution to journalArticle

    34 Citations (Scopus)

    Abstract

    Coibamide A is an N-methyl-stabilized depsipeptide that was isolated from a marine cyanobacterium as part of an International Cooperative Biodiversity Groups (ICBG) program based in Panama. Previous testing of coibamide A in the NCI in vitro 60 cancer cell line panel revealed a potent anti-proliferative response and "COMPARE-negative" profile indicative of a unique mechanism of action. We report that coibamide A is a more potent and efficacious cytotoxin than was previously appreciated, inducing concentration-and time-dependent cytotoxicity (EC50

    Original languageEnglish
    Article number e65250
    Number of pages16
    JournalPLoS ONE
    Volume8
    Issue number6
    DOIs
    Publication statusPublished - 2013

    Keywords

    • APOPTOSIS
    • INHIBITORS
    • RADIATION-THERAPY
    • IN-VITRO
    • SURVIVAL
    • MARINE CYANOBACTERIA
    • NATURAL-PRODUCTS
    • CANCER
    • RAPAMYCIN
    • MALIGNANT GLIOMA-CELLS

    Cite this

    Hau, A. M., Greenwood, J. A., Loehr, C. V., Serrill, J. D., Proteau, P. J., Ganley, I. G., ... Ishmael, J. E. (2013). Coibamide A Induces mTOR-Independent Autophagy and Cell Death in Human Glioblastoma Cells. PLoS ONE, 8(6), [ e65250]. https://doi.org/10.1371/journal.pone.0065250
    Hau, Andrew M. ; Greenwood, Jeffrey A. ; Loehr, Christiane V. ; Serrill, Jeffrey D. ; Proteau, Philip J. ; Ganley, Ian G. ; McPhail, Kerry L. ; Ishmael, Jane E. / Coibamide A Induces mTOR-Independent Autophagy and Cell Death in Human Glioblastoma Cells. In: PLoS ONE. 2013 ; Vol. 8, No. 6.
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    abstract = "Coibamide A is an N-methyl-stabilized depsipeptide that was isolated from a marine cyanobacterium as part of an International Cooperative Biodiversity Groups (ICBG) program based in Panama. Previous testing of coibamide A in the NCI in vitro 60 cancer cell line panel revealed a potent anti-proliferative response and {"}COMPARE-negative{"} profile indicative of a unique mechanism of action. We report that coibamide A is a more potent and efficacious cytotoxin than was previously appreciated, inducing concentration-and time-dependent cytotoxicity (EC50",
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    author = "Hau, {Andrew M.} and Greenwood, {Jeffrey A.} and Loehr, {Christiane V.} and Serrill, {Jeffrey D.} and Proteau, {Philip J.} and Ganley, {Ian G.} and McPhail, {Kerry L.} and Ishmael, {Jane E.}",
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    Hau, AM, Greenwood, JA, Loehr, CV, Serrill, JD, Proteau, PJ, Ganley, IG, McPhail, KL & Ishmael, JE 2013, 'Coibamide A Induces mTOR-Independent Autophagy and Cell Death in Human Glioblastoma Cells', PLoS ONE, vol. 8, no. 6, e65250. https://doi.org/10.1371/journal.pone.0065250

    Coibamide A Induces mTOR-Independent Autophagy and Cell Death in Human Glioblastoma Cells. / Hau, Andrew M.; Greenwood, Jeffrey A.; Loehr, Christiane V.; Serrill, Jeffrey D.; Proteau, Philip J.; Ganley, Ian G.; McPhail, Kerry L.; Ishmael, Jane E.

    In: PLoS ONE, Vol. 8, No. 6, e65250, 2013.

    Research output: Contribution to journalArticle

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    T1 - Coibamide A Induces mTOR-Independent Autophagy and Cell Death in Human Glioblastoma Cells

    AU - Hau, Andrew M.

    AU - Greenwood, Jeffrey A.

    AU - Loehr, Christiane V.

    AU - Serrill, Jeffrey D.

    AU - Proteau, Philip J.

    AU - Ganley, Ian G.

    AU - McPhail, Kerry L.

    AU - Ishmael, Jane E.

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    KW - RADIATION-THERAPY

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    KW - MARINE CYANOBACTERIA

    KW - NATURAL-PRODUCTS

    KW - CANCER

    KW - RAPAMYCIN

    KW - MALIGNANT GLIOMA-CELLS

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