Development and validation of the disease-specific Short Bowel Syndrome-Quality of Life (SBS-QoL™) scale

P. Berghöfer, K.C. Fragkos, J. P. Baxter, A. Forbes, F. Joly, H. Heinze, S. Loth, M. Pertkiewicz, B. Messing, P. B. Jeppesen

    Research output: Contribution to journalArticle

    20 Citations (Scopus)

    Abstract

    Background & aims: Subjects with short bowel syndrome (SBS) have impaired quality of life (QoL). No disease-specific instrument has been available to measure treatment-induced changes in QoL over time. Therefore, the aim was to develop and validate an SBS-specific QoL scale. Methods: Classical test theory and Food and Drug Administration (FDA) guidance were applied for development and validation of the SBS-QoL™. Procedures included item generation and raw scale construction. Factor analysis, construct validity and internal consistency were assessed in a non-interventional observation, test re-test reliability and responsiveness in a randomised clinical study. Results: The SBS-QoL™ comprises 17 items including two subscales. Subjects assessed the scale as easy to handle and comprehensible. Good construct validity was shown by comparison with the Home Parenteral Nutrition-Quality Of Life questionnaire as an external scale, which yielded moderately high correlation (r=0.7). High internal consistency was demonstrated (Cronbach's alpha: 0.94). Also the test re-test reliability was high (r=0.95), indicating reliable reproducibility of results. The Responsiveness Index (1.84) indicated the ability of the scale to detect changes in QoL over time. Conclusions: The SBS-QoL™ is an easy to handle and comprehensible SBS-specific subject-reported QoL scale. It is valid, reliable and sensitive with excellent psychometric characteristics to measure treatment-induced changes in QoL over time in subjects with SBS.
    Original languageEnglish
    Pages (from-to)789-796
    Number of pages8
    JournalClinical Nutrition
    Volume32
    Issue number5
    DOIs
    Publication statusPublished - 2013

    Fingerprint

    Short Bowel Syndrome
    Quality of Life
    Home Parenteral Nutrition
    Aptitude
    United States Food and Drug Administration
    Psychometrics
    Reproducibility of Results
    Statistical Factor Analysis
    Observation

    Cite this

    Berghöfer, P. ; Fragkos, K.C. ; Baxter, J. P. ; Forbes, A. ; Joly, F. ; Heinze, H. ; Loth, S. ; Pertkiewicz, M. ; Messing, B. ; Jeppesen, P. B. / Development and validation of the disease-specific Short Bowel Syndrome-Quality of Life (SBS-QoL™) scale. In: Clinical Nutrition. 2013 ; Vol. 32, No. 5. pp. 789-796.
    @article{460afb8abf784837bb4d37d138335e61,
    title = "Development and validation of the disease-specific Short Bowel Syndrome-Quality of Life (SBS-QoL™) scale",
    abstract = "Background & aims: Subjects with short bowel syndrome (SBS) have impaired quality of life (QoL). No disease-specific instrument has been available to measure treatment-induced changes in QoL over time. Therefore, the aim was to develop and validate an SBS-specific QoL scale. Methods: Classical test theory and Food and Drug Administration (FDA) guidance were applied for development and validation of the SBS-QoL™. Procedures included item generation and raw scale construction. Factor analysis, construct validity and internal consistency were assessed in a non-interventional observation, test re-test reliability and responsiveness in a randomised clinical study. Results: The SBS-QoL™ comprises 17 items including two subscales. Subjects assessed the scale as easy to handle and comprehensible. Good construct validity was shown by comparison with the Home Parenteral Nutrition-Quality Of Life questionnaire as an external scale, which yielded moderately high correlation (r=0.7). High internal consistency was demonstrated (Cronbach's alpha: 0.94). Also the test re-test reliability was high (r=0.95), indicating reliable reproducibility of results. The Responsiveness Index (1.84) indicated the ability of the scale to detect changes in QoL over time. Conclusions: The SBS-QoL™ is an easy to handle and comprehensible SBS-specific subject-reported QoL scale. It is valid, reliable and sensitive with excellent psychometric characteristics to measure treatment-induced changes in QoL over time in subjects with SBS.",
    author = "P. Bergh{\"o}fer and K.C. Fragkos and Baxter, {J. P.} and A. Forbes and F. Joly and H. Heinze and S. Loth and M. Pertkiewicz and B. Messing and Jeppesen, {P. B.}",
    year = "2013",
    doi = "10.1016/j.clnu.2012.12.001",
    language = "English",
    volume = "32",
    pages = "789--796",
    journal = "Clinical Nutrition",
    issn = "0261-5614",
    publisher = "Elsevier",
    number = "5",

    }

    Berghöfer, P, Fragkos, KC, Baxter, JP, Forbes, A, Joly, F, Heinze, H, Loth, S, Pertkiewicz, M, Messing, B & Jeppesen, PB 2013, 'Development and validation of the disease-specific Short Bowel Syndrome-Quality of Life (SBS-QoL™) scale', Clinical Nutrition, vol. 32, no. 5, pp. 789-796. https://doi.org/10.1016/j.clnu.2012.12.001

    Development and validation of the disease-specific Short Bowel Syndrome-Quality of Life (SBS-QoL™) scale. / Berghöfer, P.; Fragkos, K.C.; Baxter, J. P.; Forbes, A.; Joly, F.; Heinze, H.; Loth, S.; Pertkiewicz, M.; Messing, B.; Jeppesen, P. B.

    In: Clinical Nutrition, Vol. 32, No. 5, 2013, p. 789-796.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Development and validation of the disease-specific Short Bowel Syndrome-Quality of Life (SBS-QoL™) scale

    AU - Berghöfer, P.

    AU - Fragkos, K.C.

    AU - Baxter, J. P.

    AU - Forbes, A.

    AU - Joly, F.

    AU - Heinze, H.

    AU - Loth, S.

    AU - Pertkiewicz, M.

    AU - Messing, B.

    AU - Jeppesen, P. B.

    PY - 2013

    Y1 - 2013

    N2 - Background & aims: Subjects with short bowel syndrome (SBS) have impaired quality of life (QoL). No disease-specific instrument has been available to measure treatment-induced changes in QoL over time. Therefore, the aim was to develop and validate an SBS-specific QoL scale. Methods: Classical test theory and Food and Drug Administration (FDA) guidance were applied for development and validation of the SBS-QoL™. Procedures included item generation and raw scale construction. Factor analysis, construct validity and internal consistency were assessed in a non-interventional observation, test re-test reliability and responsiveness in a randomised clinical study. Results: The SBS-QoL™ comprises 17 items including two subscales. Subjects assessed the scale as easy to handle and comprehensible. Good construct validity was shown by comparison with the Home Parenteral Nutrition-Quality Of Life questionnaire as an external scale, which yielded moderately high correlation (r=0.7). High internal consistency was demonstrated (Cronbach's alpha: 0.94). Also the test re-test reliability was high (r=0.95), indicating reliable reproducibility of results. The Responsiveness Index (1.84) indicated the ability of the scale to detect changes in QoL over time. Conclusions: The SBS-QoL™ is an easy to handle and comprehensible SBS-specific subject-reported QoL scale. It is valid, reliable and sensitive with excellent psychometric characteristics to measure treatment-induced changes in QoL over time in subjects with SBS.

    AB - Background & aims: Subjects with short bowel syndrome (SBS) have impaired quality of life (QoL). No disease-specific instrument has been available to measure treatment-induced changes in QoL over time. Therefore, the aim was to develop and validate an SBS-specific QoL scale. Methods: Classical test theory and Food and Drug Administration (FDA) guidance were applied for development and validation of the SBS-QoL™. Procedures included item generation and raw scale construction. Factor analysis, construct validity and internal consistency were assessed in a non-interventional observation, test re-test reliability and responsiveness in a randomised clinical study. Results: The SBS-QoL™ comprises 17 items including two subscales. Subjects assessed the scale as easy to handle and comprehensible. Good construct validity was shown by comparison with the Home Parenteral Nutrition-Quality Of Life questionnaire as an external scale, which yielded moderately high correlation (r=0.7). High internal consistency was demonstrated (Cronbach's alpha: 0.94). Also the test re-test reliability was high (r=0.95), indicating reliable reproducibility of results. The Responsiveness Index (1.84) indicated the ability of the scale to detect changes in QoL over time. Conclusions: The SBS-QoL™ is an easy to handle and comprehensible SBS-specific subject-reported QoL scale. It is valid, reliable and sensitive with excellent psychometric characteristics to measure treatment-induced changes in QoL over time in subjects with SBS.

    UR - http://www.scopus.com/inward/record.url?scp=84883294494&partnerID=8YFLogxK

    U2 - 10.1016/j.clnu.2012.12.001

    DO - 10.1016/j.clnu.2012.12.001

    M3 - Article

    VL - 32

    SP - 789

    EP - 796

    JO - Clinical Nutrition

    JF - Clinical Nutrition

    SN - 0261-5614

    IS - 5

    ER -