Differences in inflammatory bowel disease phenotype between South Asians and Northern Europeans living in North West London, UK

David G. Walker, Horace R. T. Williams, Stephen P. Kane, Joel E. Mawdsley, Jayantha Arnold, Ian McNeil, Huw J. W. Thomas, Julian P. Teare, Ailsa L. Hart, Maxton C. L. Pitcher, Julian R. F. Walters, Sara E. Marshall, Timothy R. Orchard

    Research output: Contribution to journalArticle

    34 Citations (Scopus)

    Abstract

    OBJECTIVES: The incidence and prevalence of inflammatory bowel disease (IBD) is increasing throughout Asia. Since the 1950s, there has been substantial migration from South Asia (India, Pakistan, and Bangladesh) to the United Kingdom. The aim of this study was to define the clinical phenotype of IBD in UK South Asians living in North West London, and to compare the results with a white Northern European IBD cohort.

    METHODS: The phenotypic details of 367 South Asian IBD patients (273 ulcerative colitis (UC) and 94 Crohn's disease (CD)), undergoing active follow-up in five North West London hospitals, were compared with those of 403 consecutively collected white Northern European IBD patients (188 UC and 215 CD).

    RESULTS: The phenotype of IBD differed significantly between the two populations. 63.0% of South Asian UC patients had extensive colitis compared with 42.5% of the Northern European cohort (P < 0.0001). Proctitis was uncommon in South Asian UC patients (9.9 vs. 26.1% in Northern European patients, P < 0.0001). In the South Asian CD cohort, disease location was predominantly colonic (46.8%). CD behavior differed significantly between the groups, with less penetrating disease compared with Northern Europeans (P = 0.01) and a reduced need for surgery (P = 0.003).

    CONCLUSIONS: The phenotype of IBD in South Asians living in North West London is significantly different from that of a white Northern European IBD cohort. Knowledge of ethnic variations in disease phenotype may help to identify key genetic, environmental, and behavioral factors contributing to the development of IBD.

    Original languageEnglish
    Pages (from-to)1281-1289
    Number of pages9
    JournalAmerican Journal of Gastroenterology
    Volume106
    Issue number7
    DOIs
    Publication statusPublished - Jul 2011

    Keywords

    • Genome-wide association
    • Crohns disease
    • Ulcerative colitis
    • Indigenous population
    • Indian migrants
    • Smoking
    • Prevalence
    • Leicestershire
    • Epidemiology
    • Risk

    Cite this

    Walker, D. G., Williams, H. R. T., Kane, S. P., Mawdsley, J. E., Arnold, J., McNeil, I., ... Orchard, T. R. (2011). Differences in inflammatory bowel disease phenotype between South Asians and Northern Europeans living in North West London, UK. American Journal of Gastroenterology, 106(7), 1281-1289. https://doi.org/10.1038/ajg.2011.85
    Walker, David G. ; Williams, Horace R. T. ; Kane, Stephen P. ; Mawdsley, Joel E. ; Arnold, Jayantha ; McNeil, Ian ; Thomas, Huw J. W. ; Teare, Julian P. ; Hart, Ailsa L. ; Pitcher, Maxton C. L. ; Walters, Julian R. F. ; Marshall, Sara E. ; Orchard, Timothy R. / Differences in inflammatory bowel disease phenotype between South Asians and Northern Europeans living in North West London, UK. In: American Journal of Gastroenterology. 2011 ; Vol. 106, No. 7. pp. 1281-1289.
    @article{8730ecd48919436e97afac6a11594224,
    title = "Differences in inflammatory bowel disease phenotype between South Asians and Northern Europeans living in North West London, UK",
    abstract = "OBJECTIVES: The incidence and prevalence of inflammatory bowel disease (IBD) is increasing throughout Asia. Since the 1950s, there has been substantial migration from South Asia (India, Pakistan, and Bangladesh) to the United Kingdom. The aim of this study was to define the clinical phenotype of IBD in UK South Asians living in North West London, and to compare the results with a white Northern European IBD cohort.METHODS: The phenotypic details of 367 South Asian IBD patients (273 ulcerative colitis (UC) and 94 Crohn's disease (CD)), undergoing active follow-up in five North West London hospitals, were compared with those of 403 consecutively collected white Northern European IBD patients (188 UC and 215 CD).RESULTS: The phenotype of IBD differed significantly between the two populations. 63.0{\%} of South Asian UC patients had extensive colitis compared with 42.5{\%} of the Northern European cohort (P < 0.0001). Proctitis was uncommon in South Asian UC patients (9.9 vs. 26.1{\%} in Northern European patients, P < 0.0001). In the South Asian CD cohort, disease location was predominantly colonic (46.8{\%}). CD behavior differed significantly between the groups, with less penetrating disease compared with Northern Europeans (P = 0.01) and a reduced need for surgery (P = 0.003).CONCLUSIONS: The phenotype of IBD in South Asians living in North West London is significantly different from that of a white Northern European IBD cohort. Knowledge of ethnic variations in disease phenotype may help to identify key genetic, environmental, and behavioral factors contributing to the development of IBD.",
    keywords = "Genome-wide association, Crohns disease, Ulcerative colitis, Indigenous population, Indian migrants, Smoking, Prevalence, Leicestershire, Epidemiology, Risk",
    author = "Walker, {David G.} and Williams, {Horace R. T.} and Kane, {Stephen P.} and Mawdsley, {Joel E.} and Jayantha Arnold and Ian McNeil and Thomas, {Huw J. W.} and Teare, {Julian P.} and Hart, {Ailsa L.} and Pitcher, {Maxton C. L.} and Walters, {Julian R. F.} and Marshall, {Sara E.} and Orchard, {Timothy R.}",
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    Walker, DG, Williams, HRT, Kane, SP, Mawdsley, JE, Arnold, J, McNeil, I, Thomas, HJW, Teare, JP, Hart, AL, Pitcher, MCL, Walters, JRF, Marshall, SE & Orchard, TR 2011, 'Differences in inflammatory bowel disease phenotype between South Asians and Northern Europeans living in North West London, UK', American Journal of Gastroenterology, vol. 106, no. 7, pp. 1281-1289. https://doi.org/10.1038/ajg.2011.85

    Differences in inflammatory bowel disease phenotype between South Asians and Northern Europeans living in North West London, UK. / Walker, David G.; Williams, Horace R. T.; Kane, Stephen P.; Mawdsley, Joel E.; Arnold, Jayantha; McNeil, Ian; Thomas, Huw J. W.; Teare, Julian P.; Hart, Ailsa L.; Pitcher, Maxton C. L.; Walters, Julian R. F.; Marshall, Sara E.; Orchard, Timothy R.

    In: American Journal of Gastroenterology, Vol. 106, No. 7, 07.2011, p. 1281-1289.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Differences in inflammatory bowel disease phenotype between South Asians and Northern Europeans living in North West London, UK

    AU - Walker, David G.

    AU - Williams, Horace R. T.

    AU - Kane, Stephen P.

    AU - Mawdsley, Joel E.

    AU - Arnold, Jayantha

    AU - McNeil, Ian

    AU - Thomas, Huw J. W.

    AU - Teare, Julian P.

    AU - Hart, Ailsa L.

    AU - Pitcher, Maxton C. L.

    AU - Walters, Julian R. F.

    AU - Marshall, Sara E.

    AU - Orchard, Timothy R.

    PY - 2011/7

    Y1 - 2011/7

    N2 - OBJECTIVES: The incidence and prevalence of inflammatory bowel disease (IBD) is increasing throughout Asia. Since the 1950s, there has been substantial migration from South Asia (India, Pakistan, and Bangladesh) to the United Kingdom. The aim of this study was to define the clinical phenotype of IBD in UK South Asians living in North West London, and to compare the results with a white Northern European IBD cohort.METHODS: The phenotypic details of 367 South Asian IBD patients (273 ulcerative colitis (UC) and 94 Crohn's disease (CD)), undergoing active follow-up in five North West London hospitals, were compared with those of 403 consecutively collected white Northern European IBD patients (188 UC and 215 CD).RESULTS: The phenotype of IBD differed significantly between the two populations. 63.0% of South Asian UC patients had extensive colitis compared with 42.5% of the Northern European cohort (P < 0.0001). Proctitis was uncommon in South Asian UC patients (9.9 vs. 26.1% in Northern European patients, P < 0.0001). In the South Asian CD cohort, disease location was predominantly colonic (46.8%). CD behavior differed significantly between the groups, with less penetrating disease compared with Northern Europeans (P = 0.01) and a reduced need for surgery (P = 0.003).CONCLUSIONS: The phenotype of IBD in South Asians living in North West London is significantly different from that of a white Northern European IBD cohort. Knowledge of ethnic variations in disease phenotype may help to identify key genetic, environmental, and behavioral factors contributing to the development of IBD.

    AB - OBJECTIVES: The incidence and prevalence of inflammatory bowel disease (IBD) is increasing throughout Asia. Since the 1950s, there has been substantial migration from South Asia (India, Pakistan, and Bangladesh) to the United Kingdom. The aim of this study was to define the clinical phenotype of IBD in UK South Asians living in North West London, and to compare the results with a white Northern European IBD cohort.METHODS: The phenotypic details of 367 South Asian IBD patients (273 ulcerative colitis (UC) and 94 Crohn's disease (CD)), undergoing active follow-up in five North West London hospitals, were compared with those of 403 consecutively collected white Northern European IBD patients (188 UC and 215 CD).RESULTS: The phenotype of IBD differed significantly between the two populations. 63.0% of South Asian UC patients had extensive colitis compared with 42.5% of the Northern European cohort (P < 0.0001). Proctitis was uncommon in South Asian UC patients (9.9 vs. 26.1% in Northern European patients, P < 0.0001). In the South Asian CD cohort, disease location was predominantly colonic (46.8%). CD behavior differed significantly between the groups, with less penetrating disease compared with Northern Europeans (P = 0.01) and a reduced need for surgery (P = 0.003).CONCLUSIONS: The phenotype of IBD in South Asians living in North West London is significantly different from that of a white Northern European IBD cohort. Knowledge of ethnic variations in disease phenotype may help to identify key genetic, environmental, and behavioral factors contributing to the development of IBD.

    KW - Genome-wide association

    KW - Crohns disease

    KW - Ulcerative colitis

    KW - Indigenous population

    KW - Indian migrants

    KW - Smoking

    KW - Prevalence

    KW - Leicestershire

    KW - Epidemiology

    KW - Risk

    U2 - 10.1038/ajg.2011.85

    DO - 10.1038/ajg.2011.85

    M3 - Article

    VL - 106

    SP - 1281

    EP - 1289

    JO - American Journal of Gastroenterology

    JF - American Journal of Gastroenterology

    SN - 0002-9270

    IS - 7

    ER -