Does assimilation into schemas involve systems or cellular consolidation?

It's not just time

D. Tse, Rosamund Langston, I. Bethus, E. R. Wood, M. P. Witter, R. G. M. Morris

    Research output: Contribution to journalEditorial

    11 Citations (Scopus)

    Abstract

    A comment by Rudy and Sutherland [Rudy, J. R., & Sutherland, R. J. (2008). Is it systems or cellular consolidation? Time will tell. An alternative interpretation of the Morris Group's recent Science Paper. Neurobiology of Learning and Memory] has suggested an alternative account of recent findings concerning very rapid systems consolidation as described in a recent paper by Tse et al [Tse, D., Langston, R. F., Kakeyama, M., Bethus, I., Spooner, P. A., & Wood, E. R., et al. (2007). Schemas and memory consolidation. Science, 316, 76-82]. This is to suppose that excitotoxic lesions of the hippocampus cause transient disruptive neural activity outside the target structure that interferes with cellular consolidation in the cortex. We disagree with this alternative interpretation of our findings and cite relevant data in our original paper indicating why this proposal is unlikely. Various predictions of the two accounts are nonetheless outlined, together with the types of experiments needed to resolve the issue of whether systems consolidation can occur very rapidly when guided by activated neural schemas. (C) 2007 Elsevier Inc. All rights reserved.

    Original languageEnglish
    Pages (from-to)361-365
    Number of pages5
    JournalNeurobiology of Learning and Memory
    Volume89
    Issue number4
    DOIs
    Publication statusPublished - May 2008

    Keywords

    • consolidation
    • systems consolidation
    • cellular consolidation
    • schemas
    • excitoxic lesion technique
    • paired-associate learning
    • IBOTENIC ACID
    • MEMORY
    • LESIONS

    Cite this

    Tse, D. ; Langston, Rosamund ; Bethus, I. ; Wood, E. R. ; Witter, M. P. ; Morris, R. G. M. / Does assimilation into schemas involve systems or cellular consolidation? It's not just time. In: Neurobiology of Learning and Memory. 2008 ; Vol. 89, No. 4. pp. 361-365.
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    abstract = "A comment by Rudy and Sutherland [Rudy, J. R., & Sutherland, R. J. (2008). Is it systems or cellular consolidation? Time will tell. An alternative interpretation of the Morris Group's recent Science Paper. Neurobiology of Learning and Memory] has suggested an alternative account of recent findings concerning very rapid systems consolidation as described in a recent paper by Tse et al [Tse, D., Langston, R. F., Kakeyama, M., Bethus, I., Spooner, P. A., & Wood, E. R., et al. (2007). Schemas and memory consolidation. Science, 316, 76-82]. This is to suppose that excitotoxic lesions of the hippocampus cause transient disruptive neural activity outside the target structure that interferes with cellular consolidation in the cortex. We disagree with this alternative interpretation of our findings and cite relevant data in our original paper indicating why this proposal is unlikely. Various predictions of the two accounts are nonetheless outlined, together with the types of experiments needed to resolve the issue of whether systems consolidation can occur very rapidly when guided by activated neural schemas. (C) 2007 Elsevier Inc. All rights reserved.",
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    author = "D. Tse and Rosamund Langston and I. Bethus and Wood, {E. R.} and Witter, {M. P.} and Morris, {R. G. M.}",
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    Does assimilation into schemas involve systems or cellular consolidation? It's not just time. / Tse, D.; Langston, Rosamund; Bethus, I.; Wood, E. R.; Witter, M. P.; Morris, R. G. M.

    In: Neurobiology of Learning and Memory, Vol. 89, No. 4, 05.2008, p. 361-365.

    Research output: Contribution to journalEditorial

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    AU - Langston, Rosamund

    AU - Bethus, I.

    AU - Wood, E. R.

    AU - Witter, M. P.

    AU - Morris, R. G. M.

    PY - 2008/5

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    KW - LESIONS

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