Evidence for enhanced free radical activity in chronic congestive heart failure secondary to coronary artery disease

J. McMurray, J. McLay, M. Chopra, A. Bridges, J. J. F. Belch

    Research output: Contribution to journalArticle

    115 Citations (Scopus)

    Abstract

    Free radicals may be involved in the genesis of certain types of acute myocardial dysfunction (“reperfusion injury” and “stunning”). Free radicals could also be implicated in the development and progression of chronic myocardial impairment. Underlying coronary artery disease may predispose to stunning. Repeated episodes of stunning may lead to permanent myocardial dysfunction. Additional factors could also favor free radical generation in congestive heart failure (CHF). Many other organ beds such as the kidneys and skeletal muscle undergo hypoperfusion/reperfusion cycles in patients with CHF, especially during exercise. Lactic acidosis may enhance hyperoxia in these tissues. Adrenergic activity is increased in CHF.Catecholamines may augment free radical generation by increasing mitochondrial respiration and undergoing autooxidation. In support of these possibilities antioxidant therapy has been shown to protect against catecholamine cardiomyopathies in animals. We have therefore measured malondialdehyde-like material in patients with CHF. This may give some indication of lipid peroxidation, an injurious process to membranes mediated by free radicals. We have also measured plasma thiol concentration. Thiols are thought to act as free radical scavengers and reduction in plasma thiol levels may reflect oxidative stress.
    Original languageEnglish
    Pages (from-to)1261-1262
    Number of pages2
    JournalAmerican Journal of Cardiology
    Volume65
    Issue number18
    DOIs
    Publication statusPublished - 1990

    Fingerprint

    Free Radicals
    Coronary Artery Disease
    Heart Failure
    Sulfhydryl Compounds
    Catecholamines
    Myocardial Reperfusion Injury
    Lactic Acidosis
    Free Radical Scavengers
    Hyperoxia
    Malondialdehyde
    Cardiomyopathies
    Adrenergic Agents
    Lipid Peroxidation
    Reperfusion
    Respiration
    Skeletal Muscle
    Oxidative Stress
    Antioxidants
    Exercise
    Kidney

    Cite this

    @article{929430dec09a4189a4fd1e854dc445dd,
    title = "Evidence for enhanced free radical activity in chronic congestive heart failure secondary to coronary artery disease",
    abstract = "Free radicals may be involved in the genesis of certain types of acute myocardial dysfunction (“reperfusion injury” and “stunning”). Free radicals could also be implicated in the development and progression of chronic myocardial impairment. Underlying coronary artery disease may predispose to stunning. Repeated episodes of stunning may lead to permanent myocardial dysfunction. Additional factors could also favor free radical generation in congestive heart failure (CHF). Many other organ beds such as the kidneys and skeletal muscle undergo hypoperfusion/reperfusion cycles in patients with CHF, especially during exercise. Lactic acidosis may enhance hyperoxia in these tissues. Adrenergic activity is increased in CHF.Catecholamines may augment free radical generation by increasing mitochondrial respiration and undergoing autooxidation. In support of these possibilities antioxidant therapy has been shown to protect against catecholamine cardiomyopathies in animals. We have therefore measured malondialdehyde-like material in patients with CHF. This may give some indication of lipid peroxidation, an injurious process to membranes mediated by free radicals. We have also measured plasma thiol concentration. Thiols are thought to act as free radical scavengers and reduction in plasma thiol levels may reflect oxidative stress.",
    author = "J. McMurray and J. McLay and M. Chopra and A. Bridges and Belch, {J. J. F.}",
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    Evidence for enhanced free radical activity in chronic congestive heart failure secondary to coronary artery disease. / McMurray, J.; McLay, J.; Chopra, M.; Bridges, A.; Belch, J. J. F.

    In: American Journal of Cardiology, Vol. 65, No. 18, 1990, p. 1261-1262.

    Research output: Contribution to journalArticle

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    AB - Free radicals may be involved in the genesis of certain types of acute myocardial dysfunction (“reperfusion injury” and “stunning”). Free radicals could also be implicated in the development and progression of chronic myocardial impairment. Underlying coronary artery disease may predispose to stunning. Repeated episodes of stunning may lead to permanent myocardial dysfunction. Additional factors could also favor free radical generation in congestive heart failure (CHF). Many other organ beds such as the kidneys and skeletal muscle undergo hypoperfusion/reperfusion cycles in patients with CHF, especially during exercise. Lactic acidosis may enhance hyperoxia in these tissues. Adrenergic activity is increased in CHF.Catecholamines may augment free radical generation by increasing mitochondrial respiration and undergoing autooxidation. In support of these possibilities antioxidant therapy has been shown to protect against catecholamine cardiomyopathies in animals. We have therefore measured malondialdehyde-like material in patients with CHF. This may give some indication of lipid peroxidation, an injurious process to membranes mediated by free radicals. We have also measured plasma thiol concentration. Thiols are thought to act as free radical scavengers and reduction in plasma thiol levels may reflect oxidative stress.

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