GABA receptor-mediated effects in the peripheral nervous system: A cross-interaction with neuroactive steroids

Valerio Magnaghi, Marinella Ballabio, Antonio Consoli, Jeremy J. Lambert, Ilaria Roglio, Roberto C. Melcangi

Research output: Contribution to journalReview article

39 Citations (Scopus)

Abstract

γ-Aminobutyric acid (GABA), the major inhibitory neurotransmitter in the adult mammalian central nervous system (CNS), exerts its action via an interaction with specific receptors (e.g., GABAA and GABA B). These receptors are expressed not only in neurons but also on glial cells of the CNS, which might represent a target for the allosteric action of neuroactive steroids. Herein, we have demonstrated first that in the peripheral nervous system (PNS), the sciatic nerve and myelin-producing Schwann cells express both GABAA and GABAB receptors. Specific ligands, muscimol and baclofen, respectively, control Schwann-cell proliferation and expression of some specific myelin proteins (i.e., glycoprotein P0 and peripheral myelin protein 22 [PMP22]). Moreover, the progesterone (P) metabolite allopregnanolone, acting via the GABAA receptor, can influence PMP22 synthesis. In addition, we demonstrate that P, dihydroprogesterone, and allopregnanolone influence the expression of GABAB subunits in Schwann cells. The results suggest, at least in the myelinating cells of the PNS, a cross-interaction within the GABAergic receptor system, via GABA A and GABAB receptors and neuroactive steroids.

Original languageEnglish
Pages (from-to)89-102
Number of pages14
JournalJournal of Molecular Neuroscience
Volume28
Issue number1
DOIs
Publication statusPublished - Jan 2006

Fingerprint

GABA Receptors
Schwann Cells
Peripheral Nervous System
Neurology
GABA-A Receptors
Myelin Proteins
Pregnanolone
Steroids
gamma-Aminobutyric Acid
Central Nervous System
Myelin P0 Protein
20-alpha-Dihydroprogesterone
Aminobutyrates
Muscimol
Baclofen
Cells
Sciatic Nerve
Myelin Sheath
Neuroglia
Progesterone

Keywords

  • Allopregnanolone
  • GABA receptor
  • Myelin
  • Peripheral nervous system
  • Progesterone
  • Schwann cell

Cite this

Magnaghi, Valerio ; Ballabio, Marinella ; Consoli, Antonio ; Lambert, Jeremy J. ; Roglio, Ilaria ; Melcangi, Roberto C. / GABA receptor-mediated effects in the peripheral nervous system : A cross-interaction with neuroactive steroids. In: Journal of Molecular Neuroscience. 2006 ; Vol. 28, No. 1. pp. 89-102.
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abstract = "γ-Aminobutyric acid (GABA), the major inhibitory neurotransmitter in the adult mammalian central nervous system (CNS), exerts its action via an interaction with specific receptors (e.g., GABAA and GABA B). These receptors are expressed not only in neurons but also on glial cells of the CNS, which might represent a target for the allosteric action of neuroactive steroids. Herein, we have demonstrated first that in the peripheral nervous system (PNS), the sciatic nerve and myelin-producing Schwann cells express both GABAA and GABAB receptors. Specific ligands, muscimol and baclofen, respectively, control Schwann-cell proliferation and expression of some specific myelin proteins (i.e., glycoprotein P0 and peripheral myelin protein 22 [PMP22]). Moreover, the progesterone (P) metabolite allopregnanolone, acting via the GABAA receptor, can influence PMP22 synthesis. In addition, we demonstrate that P, dihydroprogesterone, and allopregnanolone influence the expression of GABAB subunits in Schwann cells. The results suggest, at least in the myelinating cells of the PNS, a cross-interaction within the GABAergic receptor system, via GABA A and GABAB receptors and neuroactive steroids.",
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GABA receptor-mediated effects in the peripheral nervous system : A cross-interaction with neuroactive steroids. / Magnaghi, Valerio; Ballabio, Marinella; Consoli, Antonio; Lambert, Jeremy J.; Roglio, Ilaria; Melcangi, Roberto C.

In: Journal of Molecular Neuroscience, Vol. 28, No. 1, 01.2006, p. 89-102.

Research output: Contribution to journalReview article

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T2 - A cross-interaction with neuroactive steroids

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AB - γ-Aminobutyric acid (GABA), the major inhibitory neurotransmitter in the adult mammalian central nervous system (CNS), exerts its action via an interaction with specific receptors (e.g., GABAA and GABA B). These receptors are expressed not only in neurons but also on glial cells of the CNS, which might represent a target for the allosteric action of neuroactive steroids. Herein, we have demonstrated first that in the peripheral nervous system (PNS), the sciatic nerve and myelin-producing Schwann cells express both GABAA and GABAB receptors. Specific ligands, muscimol and baclofen, respectively, control Schwann-cell proliferation and expression of some specific myelin proteins (i.e., glycoprotein P0 and peripheral myelin protein 22 [PMP22]). Moreover, the progesterone (P) metabolite allopregnanolone, acting via the GABAA receptor, can influence PMP22 synthesis. In addition, we demonstrate that P, dihydroprogesterone, and allopregnanolone influence the expression of GABAB subunits in Schwann cells. The results suggest, at least in the myelinating cells of the PNS, a cross-interaction within the GABAergic receptor system, via GABA A and GABAB receptors and neuroactive steroids.

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