HATs off to capping

a new mechanism for Myc

Victoria H. Cowling, Michael D. Cole

    Research output: Contribution to journalReview article

    6 Citations (Scopus)

    Abstract

    The mechanism of transcriptional activation by Myc has been a subject of considerable interest for many years. Recently we reported a novel Myc biochemical function in gene regulation which is distinct from conventional transcriptional activation. Myc can induce global RNA pol II carboxy terminal domain phosphorylation and enhanced mRNA cap methylation on a subset of mRNAs. Remarkably, Myc can induce many of these effects in the complete absence of its DNA binding domain. We further discuss the mechanism of Myc-induced cap methylation, its synergistic relationship with Myc induced transcription, and the role of Myc in cell proliferation.
    Original languageEnglish
    Pages (from-to)907-9
    Number of pages3
    JournalCell Cycle
    Volume6
    Issue number8
    DOIs
    Publication statusPublished - 2007

    Fingerprint

    Methylation
    Transcriptional Activation
    Messenger RNA
    RNA Polymerase II
    Phosphorylation
    Cell Proliferation
    DNA
    Genes

    Cite this

    Cowling, Victoria H. ; Cole, Michael D. / HATs off to capping : a new mechanism for Myc. In: Cell Cycle. 2007 ; Vol. 6, No. 8. pp. 907-9.
    @article{ff24556eaa9046e885ccb0494f5fcc99,
    title = "HATs off to capping: a new mechanism for Myc",
    abstract = "The mechanism of transcriptional activation by Myc has been a subject of considerable interest for many years. Recently we reported a novel Myc biochemical function in gene regulation which is distinct from conventional transcriptional activation. Myc can induce global RNA pol II carboxy terminal domain phosphorylation and enhanced mRNA cap methylation on a subset of mRNAs. Remarkably, Myc can induce many of these effects in the complete absence of its DNA binding domain. We further discuss the mechanism of Myc-induced cap methylation, its synergistic relationship with Myc induced transcription, and the role of Myc in cell proliferation.",
    author = "Cowling, {Victoria H.} and Cole, {Michael D.}",
    year = "2007",
    doi = "10.4161/cc.6.8.4123",
    language = "English",
    volume = "6",
    pages = "907--9",
    journal = "Cell Cycle",
    issn = "1538-4101",
    publisher = "Taylor & Francis",
    number = "8",

    }

    HATs off to capping : a new mechanism for Myc. / Cowling, Victoria H.; Cole, Michael D.

    In: Cell Cycle, Vol. 6, No. 8, 2007, p. 907-9.

    Research output: Contribution to journalReview article

    TY - JOUR

    T1 - HATs off to capping

    T2 - a new mechanism for Myc

    AU - Cowling, Victoria H.

    AU - Cole, Michael D.

    PY - 2007

    Y1 - 2007

    N2 - The mechanism of transcriptional activation by Myc has been a subject of considerable interest for many years. Recently we reported a novel Myc biochemical function in gene regulation which is distinct from conventional transcriptional activation. Myc can induce global RNA pol II carboxy terminal domain phosphorylation and enhanced mRNA cap methylation on a subset of mRNAs. Remarkably, Myc can induce many of these effects in the complete absence of its DNA binding domain. We further discuss the mechanism of Myc-induced cap methylation, its synergistic relationship with Myc induced transcription, and the role of Myc in cell proliferation.

    AB - The mechanism of transcriptional activation by Myc has been a subject of considerable interest for many years. Recently we reported a novel Myc biochemical function in gene regulation which is distinct from conventional transcriptional activation. Myc can induce global RNA pol II carboxy terminal domain phosphorylation and enhanced mRNA cap methylation on a subset of mRNAs. Remarkably, Myc can induce many of these effects in the complete absence of its DNA binding domain. We further discuss the mechanism of Myc-induced cap methylation, its synergistic relationship with Myc induced transcription, and the role of Myc in cell proliferation.

    U2 - 10.4161/cc.6.8.4123

    DO - 10.4161/cc.6.8.4123

    M3 - Review article

    VL - 6

    SP - 907

    EP - 909

    JO - Cell Cycle

    JF - Cell Cycle

    SN - 1538-4101

    IS - 8

    ER -