High levels of apoptosis are associated with improved survival in non-small cell lung cancer

M Macluskey, R Baillie, L M Chandrachud, N Pendleton, A M Schor

    Research output: Contribution to journalArticle

    16 Citations (Scopus)

    Abstract

    Tumour growth is accompanied by angiogenesis and reduced apoptosis in experimental animals. The aim of this study was to examine the prognostic value of apoptosis and the association between apoptosis and vascularity in non-small cell lung cancer (NSCLC). Following in-situ end-labelling of DNA, apoptotic cells were quantified by three different indices: as a percentage, either counting total cells (AI-tc) or point-counting (AI-pc), or as cells per area (AI-area). Blood vessels were stained with vWF antibody and vascularity was quantified by three methods. Median values for AI-tc, AI-pc and AI-area were 0.38, 0.32 and 10.7, respectively. High values were associated with improved survival, reaching statistical significance for AI-area (p <0.05). All three apoptotic indices were significantly correlated with each other, but no correlation was found between indices of apoptosis and vascularity. As previously reported, vascularity had no prognostic value. These results indicate that, in NSCLC, vascularity is not informative, but apoptotic index may be a useful prognostic factor.
    Original languageEnglish
    Pages (from-to)2123-8
    Number of pages6
    JournalAnticancer Research
    Volume20
    Issue number3B
    Publication statusPublished - 2000

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    Non-Small Cell Lung Carcinoma
    Apoptosis
    Blood Vessels
    Antibodies
    DNA
    Growth
    Neoplasms

    Cite this

    Macluskey, M., Baillie, R., Chandrachud, L. M., Pendleton, N., & Schor, A. M. (2000). High levels of apoptosis are associated with improved survival in non-small cell lung cancer. Anticancer Research, 20(3B), 2123-8.
    Macluskey, M ; Baillie, R ; Chandrachud, L M ; Pendleton, N ; Schor, A M. / High levels of apoptosis are associated with improved survival in non-small cell lung cancer. In: Anticancer Research. 2000 ; Vol. 20, No. 3B. pp. 2123-8.
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    title = "High levels of apoptosis are associated with improved survival in non-small cell lung cancer",
    abstract = "Tumour growth is accompanied by angiogenesis and reduced apoptosis in experimental animals. The aim of this study was to examine the prognostic value of apoptosis and the association between apoptosis and vascularity in non-small cell lung cancer (NSCLC). Following in-situ end-labelling of DNA, apoptotic cells were quantified by three different indices: as a percentage, either counting total cells (AI-tc) or point-counting (AI-pc), or as cells per area (AI-area). Blood vessels were stained with vWF antibody and vascularity was quantified by three methods. Median values for AI-tc, AI-pc and AI-area were 0.38, 0.32 and 10.7, respectively. High values were associated with improved survival, reaching statistical significance for AI-area (p <0.05). All three apoptotic indices were significantly correlated with each other, but no correlation was found between indices of apoptosis and vascularity. As previously reported, vascularity had no prognostic value. These results indicate that, in NSCLC, vascularity is not informative, but apoptotic index may be a useful prognostic factor.",
    author = "M Macluskey and R Baillie and Chandrachud, {L M} and N Pendleton and Schor, {A M}",
    year = "2000",
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    Macluskey, M, Baillie, R, Chandrachud, LM, Pendleton, N & Schor, AM 2000, 'High levels of apoptosis are associated with improved survival in non-small cell lung cancer', Anticancer Research, vol. 20, no. 3B, pp. 2123-8.

    High levels of apoptosis are associated with improved survival in non-small cell lung cancer. / Macluskey, M; Baillie, R; Chandrachud, L M; Pendleton, N; Schor, A M.

    In: Anticancer Research, Vol. 20, No. 3B, 2000, p. 2123-8.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - High levels of apoptosis are associated with improved survival in non-small cell lung cancer

    AU - Macluskey, M

    AU - Baillie, R

    AU - Chandrachud, L M

    AU - Pendleton, N

    AU - Schor, A M

    PY - 2000

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    N2 - Tumour growth is accompanied by angiogenesis and reduced apoptosis in experimental animals. The aim of this study was to examine the prognostic value of apoptosis and the association between apoptosis and vascularity in non-small cell lung cancer (NSCLC). Following in-situ end-labelling of DNA, apoptotic cells were quantified by three different indices: as a percentage, either counting total cells (AI-tc) or point-counting (AI-pc), or as cells per area (AI-area). Blood vessels were stained with vWF antibody and vascularity was quantified by three methods. Median values for AI-tc, AI-pc and AI-area were 0.38, 0.32 and 10.7, respectively. High values were associated with improved survival, reaching statistical significance for AI-area (p <0.05). All three apoptotic indices were significantly correlated with each other, but no correlation was found between indices of apoptosis and vascularity. As previously reported, vascularity had no prognostic value. These results indicate that, in NSCLC, vascularity is not informative, but apoptotic index may be a useful prognostic factor.

    AB - Tumour growth is accompanied by angiogenesis and reduced apoptosis in experimental animals. The aim of this study was to examine the prognostic value of apoptosis and the association between apoptosis and vascularity in non-small cell lung cancer (NSCLC). Following in-situ end-labelling of DNA, apoptotic cells were quantified by three different indices: as a percentage, either counting total cells (AI-tc) or point-counting (AI-pc), or as cells per area (AI-area). Blood vessels were stained with vWF antibody and vascularity was quantified by three methods. Median values for AI-tc, AI-pc and AI-area were 0.38, 0.32 and 10.7, respectively. High values were associated with improved survival, reaching statistical significance for AI-area (p <0.05). All three apoptotic indices were significantly correlated with each other, but no correlation was found between indices of apoptosis and vascularity. As previously reported, vascularity had no prognostic value. These results indicate that, in NSCLC, vascularity is not informative, but apoptotic index may be a useful prognostic factor.

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