Long-term adherence to statin treatment in diabetes

    Research output: Contribution to journalArticle

    58 Citations (Scopus)

    Abstract

    Aims To determine the patterns and predictors of long-term adherence to statin therapy in all patients with diabetes in the community setting.

    Methods We retrospectively studied patients with diabetes who were resident in Tayside, Scotland from 1 January 1989 to 31 May 2003 and initiated statin treatment during that time. The main outcome measure was percentage of days covered (PDC) by a statin, calculated at regular intervals. Predictors of suboptimal adherence (PDC < 80%) were identified using generalized linear models for repeated measures.

    Results Six thousand four hundred and sixty-two patients were included in the study. In the first year, the mean PDC was 87, 61% in the first and second quarter, respectively, and 65% after 13 years. Less than 50% of patients maintained a PDC of > 80% after 13 years. Predictors of poor long-term adherence were younger age, higher HbA(1c), no history of smoking, no cardiovascular morbidity at baseline and occurrence of cardiovascular disease after statin commencement.

    Conclusions This study suggests that barriers to long-term adherence to statins tend to arise early on in the therapeutic course. In general, long-term adherence is poor in patients with diabetes, especially among those with few other cardiovascular risk factors.

    Original languageEnglish
    Pages (from-to)850-855
    Number of pages6
    JournalDiabetic Medicine
    Volume25
    Issue number7
    DOIs
    Publication statusPublished - Jul 2008

    Keywords

    • adherence
    • diabetes
    • population
    • statins
    • CORONARY-HEART-DISEASE
    • CHOLESTEROL LEVELS
    • ELDERLY PATIENTS
    • THERAPY
    • PERSISTENCE
    • PREVENTION
    • TRIALS
    • RISK
    • MEN
    • ATHEROSCLEROSIS

    Cite this

    @article{c02ed8ec2c9d4a7287a96eba0c4bd5b7,
    title = "Long-term adherence to statin treatment in diabetes",
    abstract = "Aims To determine the patterns and predictors of long-term adherence to statin therapy in all patients with diabetes in the community setting.Methods We retrospectively studied patients with diabetes who were resident in Tayside, Scotland from 1 January 1989 to 31 May 2003 and initiated statin treatment during that time. The main outcome measure was percentage of days covered (PDC) by a statin, calculated at regular intervals. Predictors of suboptimal adherence (PDC < 80{\%}) were identified using generalized linear models for repeated measures.Results Six thousand four hundred and sixty-two patients were included in the study. In the first year, the mean PDC was 87, 61{\%} in the first and second quarter, respectively, and 65{\%} after 13 years. Less than 50{\%} of patients maintained a PDC of > 80{\%} after 13 years. Predictors of poor long-term adherence were younger age, higher HbA(1c), no history of smoking, no cardiovascular morbidity at baseline and occurrence of cardiovascular disease after statin commencement.Conclusions This study suggests that barriers to long-term adherence to statins tend to arise early on in the therapeutic course. In general, long-term adherence is poor in patients with diabetes, especially among those with few other cardiovascular risk factors.",
    keywords = "adherence, diabetes, population, statins, CORONARY-HEART-DISEASE, CHOLESTEROL LEVELS, ELDERLY PATIENTS, THERAPY, PERSISTENCE, PREVENTION, TRIALS, RISK, MEN, ATHEROSCLEROSIS",
    author = "Donnelly, {L. A.} and Doney, {A. S. F.} and Morris, {A. D.} and Palmer, {C. N. A.} and Donnan, {P. T.}",
    year = "2008",
    month = "7",
    doi = "10.1111/j.1464-5491.2008.02476.x",
    language = "English",
    volume = "25",
    pages = "850--855",
    journal = "Diabetic Medicine",
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    }

    Long-term adherence to statin treatment in diabetes. / Donnelly, L. A.; Doney, A. S. F.; Morris, A. D.; Palmer, C. N. A.; Donnan, P. T.

    In: Diabetic Medicine, Vol. 25, No. 7, 07.2008, p. 850-855.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Long-term adherence to statin treatment in diabetes

    AU - Donnelly, L. A.

    AU - Doney, A. S. F.

    AU - Morris, A. D.

    AU - Palmer, C. N. A.

    AU - Donnan, P. T.

    PY - 2008/7

    Y1 - 2008/7

    N2 - Aims To determine the patterns and predictors of long-term adherence to statin therapy in all patients with diabetes in the community setting.Methods We retrospectively studied patients with diabetes who were resident in Tayside, Scotland from 1 January 1989 to 31 May 2003 and initiated statin treatment during that time. The main outcome measure was percentage of days covered (PDC) by a statin, calculated at regular intervals. Predictors of suboptimal adherence (PDC < 80%) were identified using generalized linear models for repeated measures.Results Six thousand four hundred and sixty-two patients were included in the study. In the first year, the mean PDC was 87, 61% in the first and second quarter, respectively, and 65% after 13 years. Less than 50% of patients maintained a PDC of > 80% after 13 years. Predictors of poor long-term adherence were younger age, higher HbA(1c), no history of smoking, no cardiovascular morbidity at baseline and occurrence of cardiovascular disease after statin commencement.Conclusions This study suggests that barriers to long-term adherence to statins tend to arise early on in the therapeutic course. In general, long-term adherence is poor in patients with diabetes, especially among those with few other cardiovascular risk factors.

    AB - Aims To determine the patterns and predictors of long-term adherence to statin therapy in all patients with diabetes in the community setting.Methods We retrospectively studied patients with diabetes who were resident in Tayside, Scotland from 1 January 1989 to 31 May 2003 and initiated statin treatment during that time. The main outcome measure was percentage of days covered (PDC) by a statin, calculated at regular intervals. Predictors of suboptimal adherence (PDC < 80%) were identified using generalized linear models for repeated measures.Results Six thousand four hundred and sixty-two patients were included in the study. In the first year, the mean PDC was 87, 61% in the first and second quarter, respectively, and 65% after 13 years. Less than 50% of patients maintained a PDC of > 80% after 13 years. Predictors of poor long-term adherence were younger age, higher HbA(1c), no history of smoking, no cardiovascular morbidity at baseline and occurrence of cardiovascular disease after statin commencement.Conclusions This study suggests that barriers to long-term adherence to statins tend to arise early on in the therapeutic course. In general, long-term adherence is poor in patients with diabetes, especially among those with few other cardiovascular risk factors.

    KW - adherence

    KW - diabetes

    KW - population

    KW - statins

    KW - CORONARY-HEART-DISEASE

    KW - CHOLESTEROL LEVELS

    KW - ELDERLY PATIENTS

    KW - THERAPY

    KW - PERSISTENCE

    KW - PREVENTION

    KW - TRIALS

    KW - RISK

    KW - MEN

    KW - ATHEROSCLEROSIS

    U2 - 10.1111/j.1464-5491.2008.02476.x

    DO - 10.1111/j.1464-5491.2008.02476.x

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    JO - Diabetic Medicine

    JF - Diabetic Medicine

    SN - 0742-3071

    IS - 7

    ER -