Nanotechnology in multimodal theranostic capsule endoscopy

S. Cochran (Lead / Corresponding author), T. W. Button, B. F. Cox, D. R. S. Cumming, D. Gourevich, H. S. Lay, H. Mulvana, I. S. Nathke, F. Stewart

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Abstract

Video capsule endoscopy (VCE) has become a clinically accepted diagnostic modality in the last 20 years and has established a technological roadmap for other capsule endoscopy (CE) devices, incorporating microscale technology, a local power supply and wireless communication. However, VCE does not provide a therapeutic function and research in therapeutic capsule endoscopy (TCE) has been limited. This paper proposes a new route towards viable TCE based on multiple CE devices including essential nanoscale components. A first device is used for multimodal diagnosis, with quantitative microultrasound as a complement to video imaging. Ultrasound-enhanced fluorescent marking of sites of pathology allows follow-up with a second device for therapy. This is based on fluorescence imaging and ultrasound-mediated targeted drug delivery. Subsequent treatment verification and monitoring with a third device exploits the minimally invasive nature of CE. Clinical implementation of a complete patient pathway remains the subject of research but several key components have been prepared in early prototype form. These are described, along with gaps that remain to be filled.

Original languageEnglish
Title of host publication2017 IEEE 17th International Conference on Nanotechnology, NANO 2017
Place of PublicationUnited States
PublisherIEEE
Pages434-435
Number of pages2
ISBN (Electronic)9781509030286
DOIs
Publication statusPublished - 23 Nov 2017
Event17th IEEE International Conference on Nanotechnology, NANO 2017 - Pittsburgh, United States
Duration: 25 Jul 201728 Jul 2017

Conference

Conference17th IEEE International Conference on Nanotechnology, NANO 2017
CountryUnited States
CityPittsburgh
Period25/07/1728/07/17

Fingerprint

Endoscopy
Nanotechnology
Capsules
Ultrasonics
Imaging techniques
Pathology
Fluorescence
Monitoring
Communication

Keywords

  • Drugs
  • Nanoscale devices
  • Fluorescence
  • Endoscopes
  • Imaging
  • Ultrasonic imaging

Cite this

Cochran, S., Button, T. W., Cox, B. F., Cumming, D. R. S., Gourevich, D., Lay, H. S., ... Stewart, F. (2017). Nanotechnology in multimodal theranostic capsule endoscopy. In 2017 IEEE 17th International Conference on Nanotechnology, NANO 2017 (pp. 434-435). [8117439] United States: IEEE. https://doi.org/10.1109/NANO.2017.8117439
Cochran, S. ; Button, T. W. ; Cox, B. F. ; Cumming, D. R. S. ; Gourevich, D. ; Lay, H. S. ; Mulvana, H. ; Nathke, I. S. ; Stewart, F. / Nanotechnology in multimodal theranostic capsule endoscopy. 2017 IEEE 17th International Conference on Nanotechnology, NANO 2017. United States : IEEE, 2017. pp. 434-435
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title = "Nanotechnology in multimodal theranostic capsule endoscopy",
abstract = "Video capsule endoscopy (VCE) has become a clinically accepted diagnostic modality in the last 20 years and has established a technological roadmap for other capsule endoscopy (CE) devices, incorporating microscale technology, a local power supply and wireless communication. However, VCE does not provide a therapeutic function and research in therapeutic capsule endoscopy (TCE) has been limited. This paper proposes a new route towards viable TCE based on multiple CE devices including essential nanoscale components. A first device is used for multimodal diagnosis, with quantitative microultrasound as a complement to video imaging. Ultrasound-enhanced fluorescent marking of sites of pathology allows follow-up with a second device for therapy. This is based on fluorescence imaging and ultrasound-mediated targeted drug delivery. Subsequent treatment verification and monitoring with a third device exploits the minimally invasive nature of CE. Clinical implementation of a complete patient pathway remains the subject of research but several key components have been prepared in early prototype form. These are described, along with gaps that remain to be filled.",
keywords = "Drugs, Nanoscale devices, Fluorescence, Endoscopes, Imaging, Ultrasonic imaging",
author = "S. Cochran and Button, {T. W.} and Cox, {B. F.} and Cumming, {D. R. S.} and D. Gourevich and Lay, {H. S.} and H. Mulvana and Nathke, {I. S.} and F. Stewart",
note = "This research is supported by the UK EPSRC Sonopill Programme, ref. GR/K034537. It previously drew support from the EU Nanoporation project, ref. 230674.",
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Cochran, S, Button, TW, Cox, BF, Cumming, DRS, Gourevich, D, Lay, HS, Mulvana, H, Nathke, IS & Stewart, F 2017, Nanotechnology in multimodal theranostic capsule endoscopy. in 2017 IEEE 17th International Conference on Nanotechnology, NANO 2017., 8117439, IEEE, United States, pp. 434-435, 17th IEEE International Conference on Nanotechnology, NANO 2017, Pittsburgh, United States, 25/07/17. https://doi.org/10.1109/NANO.2017.8117439

Nanotechnology in multimodal theranostic capsule endoscopy. / Cochran, S. (Lead / Corresponding author); Button, T. W.; Cox, B. F.; Cumming, D. R. S.; Gourevich, D.; Lay, H. S.; Mulvana, H.; Nathke, I. S.; Stewart, F.

2017 IEEE 17th International Conference on Nanotechnology, NANO 2017. United States : IEEE, 2017. p. 434-435 8117439.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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AU - Button, T. W.

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N2 - Video capsule endoscopy (VCE) has become a clinically accepted diagnostic modality in the last 20 years and has established a technological roadmap for other capsule endoscopy (CE) devices, incorporating microscale technology, a local power supply and wireless communication. However, VCE does not provide a therapeutic function and research in therapeutic capsule endoscopy (TCE) has been limited. This paper proposes a new route towards viable TCE based on multiple CE devices including essential nanoscale components. A first device is used for multimodal diagnosis, with quantitative microultrasound as a complement to video imaging. Ultrasound-enhanced fluorescent marking of sites of pathology allows follow-up with a second device for therapy. This is based on fluorescence imaging and ultrasound-mediated targeted drug delivery. Subsequent treatment verification and monitoring with a third device exploits the minimally invasive nature of CE. Clinical implementation of a complete patient pathway remains the subject of research but several key components have been prepared in early prototype form. These are described, along with gaps that remain to be filled.

AB - Video capsule endoscopy (VCE) has become a clinically accepted diagnostic modality in the last 20 years and has established a technological roadmap for other capsule endoscopy (CE) devices, incorporating microscale technology, a local power supply and wireless communication. However, VCE does not provide a therapeutic function and research in therapeutic capsule endoscopy (TCE) has been limited. This paper proposes a new route towards viable TCE based on multiple CE devices including essential nanoscale components. A first device is used for multimodal diagnosis, with quantitative microultrasound as a complement to video imaging. Ultrasound-enhanced fluorescent marking of sites of pathology allows follow-up with a second device for therapy. This is based on fluorescence imaging and ultrasound-mediated targeted drug delivery. Subsequent treatment verification and monitoring with a third device exploits the minimally invasive nature of CE. Clinical implementation of a complete patient pathway remains the subject of research but several key components have been prepared in early prototype form. These are described, along with gaps that remain to be filled.

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Cochran S, Button TW, Cox BF, Cumming DRS, Gourevich D, Lay HS et al. Nanotechnology in multimodal theranostic capsule endoscopy. In 2017 IEEE 17th International Conference on Nanotechnology, NANO 2017. United States: IEEE. 2017. p. 434-435. 8117439 https://doi.org/10.1109/NANO.2017.8117439