Oncogene-Stimulated Congestion at the KEAP1 Stress Signaling Hub Allows Bypass of NRF2 and Induction of NRF2-Target Genes that Promote Tumor Survival

John D. Hayes, Albena T. Dinkova-Kostova (Lead / Corresponding author)

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    4 Citations (Scopus)
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    Abstract

    In this issue of Cancer Cell, Ge et al. show that overexpression of the oncoprotein iASPP in cancer cells provokes NRF2-mediated induction of cytoprotective genes, because it logjams the ubiquitin ligase substrate adaptor function of KEAP1 by virtue of the fact that it possesses a novel DLT-containing KEAP1-interaction motif.

    Original languageEnglish
    Pages (from-to)539-541
    Number of pages3
    JournalCancer Cell
    Volume32
    Issue number5
    Early online date13 Nov 2017
    DOIs
    Publication statusPublished - Nov 2017

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    Oncogenes
    Oncogene Proteins
    Ligases
    Ubiquitin
    Genes
    Neoplasms

    Cite this

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    title = "Oncogene-Stimulated Congestion at the KEAP1 Stress Signaling Hub Allows Bypass of NRF2 and Induction of NRF2-Target Genes that Promote Tumor Survival",
    abstract = "In this issue of Cancer Cell, Ge et al. show that overexpression of the oncoprotein iASPP in cancer cells provokes NRF2-mediated induction of cytoprotective genes, because it logjams the ubiquitin ligase substrate adaptor function of KEAP1 by virtue of the fact that it possesses a novel DLT-containing KEAP1-interaction motif.",
    author = "Hayes, {John D.} and Dinkova-Kostova, {Albena T.}",
    note = "The authors are supported by grant MR/N009851/1 from the Medical Research Council of the UK and grant C20953/A18644 from Cancer Research UK.",
    year = "2017",
    month = "11",
    doi = "10.1016/j.ccell.2017.10.009",
    language = "English",
    volume = "32",
    pages = "539--541",
    journal = "Cancer Cell",
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    publisher = "Elsevier",
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    T1 - Oncogene-Stimulated Congestion at the KEAP1 Stress Signaling Hub Allows Bypass of NRF2 and Induction of NRF2-Target Genes that Promote Tumor Survival

    AU - Hayes, John D.

    AU - Dinkova-Kostova, Albena T.

    N1 - The authors are supported by grant MR/N009851/1 from the Medical Research Council of the UK and grant C20953/A18644 from Cancer Research UK.

    PY - 2017/11

    Y1 - 2017/11

    N2 - In this issue of Cancer Cell, Ge et al. show that overexpression of the oncoprotein iASPP in cancer cells provokes NRF2-mediated induction of cytoprotective genes, because it logjams the ubiquitin ligase substrate adaptor function of KEAP1 by virtue of the fact that it possesses a novel DLT-containing KEAP1-interaction motif.

    AB - In this issue of Cancer Cell, Ge et al. show that overexpression of the oncoprotein iASPP in cancer cells provokes NRF2-mediated induction of cytoprotective genes, because it logjams the ubiquitin ligase substrate adaptor function of KEAP1 by virtue of the fact that it possesses a novel DLT-containing KEAP1-interaction motif.

    UR - http://www.scopus.com/inward/record.url?scp=85033721839&partnerID=8YFLogxK

    U2 - 10.1016/j.ccell.2017.10.009

    DO - 10.1016/j.ccell.2017.10.009

    M3 - Article

    VL - 32

    SP - 539

    EP - 541

    JO - Cancer Cell

    JF - Cancer Cell

    SN - 1535-6108

    IS - 5

    ER -