Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism

Christoph Sachse, Upinder Bhambra, Gillian Smith, Tracy J. Lightfoot, Jennifer H. Barrett, Jenna Scollay, R. Colin Garner, Alan R. Boobis, C. Roland Wolf, Nigel J. Gooderham, Colorectal Cancer Study Group

    Research output: Contribution to journalArticle

    142 Citations (Scopus)

    Abstract

    Several single nucleotide polymorphisms (SNPs) of the cytochrome P450 enzyme 1A2 gene (CYP1A2) have been reported. Here, frequencies, linkage disequilibrium and phenotypic consequences of six SNPs are described.
    Original languageEnglish
    Pages (from-to)68-76
    Number of pages9
    JournalBritish Journal of Clinical Pharmacology
    Volume55
    Issue number1
    DOIs
    Publication statusPublished - 2003

    Fingerprint

    Cytochrome P-450 CYP1A2
    Linkage Disequilibrium
    Caffeine
    Gene Frequency
    Cytochrome P-450 Enzyme System
    Single Nucleotide Polymorphism
    Colorectal Neoplasms
    Genes

    Cite this

    Sachse, Christoph ; Bhambra, Upinder ; Smith, Gillian ; Lightfoot, Tracy J. ; Barrett, Jennifer H. ; Scollay, Jenna ; Garner, R. Colin ; Boobis, Alan R. ; Wolf, C. Roland ; Gooderham, Nigel J. ; Colorectal Cancer Study Group. / Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls : allele frequencies, linkage disequilibrium and influence on caffeine metabolism. In: British Journal of Clinical Pharmacology. 2003 ; Vol. 55, No. 1. pp. 68-76.
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    title = "Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism",
    abstract = "Several single nucleotide polymorphisms (SNPs) of the cytochrome P450 enzyme 1A2 gene (CYP1A2) have been reported. Here, frequencies, linkage disequilibrium and phenotypic consequences of six SNPs are described.",
    author = "Christoph Sachse and Upinder Bhambra and Gillian Smith and Lightfoot, {Tracy J.} and Barrett, {Jennifer H.} and Jenna Scollay and Garner, {R. Colin} and Boobis, {Alan R.} and Wolf, {C. Roland} and Gooderham, {Nigel J.} and {Colorectal Cancer Study Group}",
    year = "2003",
    doi = "10.1046/j.1365-2125.2003.01733.x",
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    Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls : allele frequencies, linkage disequilibrium and influence on caffeine metabolism. / Sachse, Christoph; Bhambra, Upinder; Smith, Gillian; Lightfoot, Tracy J.; Barrett, Jennifer H.; Scollay, Jenna; Garner, R. Colin; Boobis, Alan R.; Wolf, C. Roland; Gooderham, Nigel J.; Colorectal Cancer Study Group.

    In: British Journal of Clinical Pharmacology, Vol. 55, No. 1, 2003, p. 68-76.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls

    T2 - allele frequencies, linkage disequilibrium and influence on caffeine metabolism

    AU - Sachse, Christoph

    AU - Bhambra, Upinder

    AU - Smith, Gillian

    AU - Lightfoot, Tracy J.

    AU - Barrett, Jennifer H.

    AU - Scollay, Jenna

    AU - Garner, R. Colin

    AU - Boobis, Alan R.

    AU - Wolf, C. Roland

    AU - Gooderham, Nigel J.

    AU - Colorectal Cancer Study Group

    PY - 2003

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    AB - Several single nucleotide polymorphisms (SNPs) of the cytochrome P450 enzyme 1A2 gene (CYP1A2) have been reported. Here, frequencies, linkage disequilibrium and phenotypic consequences of six SNPs are described.

    U2 - 10.1046/j.1365-2125.2003.01733.x

    DO - 10.1046/j.1365-2125.2003.01733.x

    M3 - Article

    C2 - 12534642

    VL - 55

    SP - 68

    EP - 76

    JO - British Journal of Clinical Pharmacology

    JF - British Journal of Clinical Pharmacology

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