Pre-operative stromal stiffness measured by shear wave elastography is independently associated with breast cancer specific survival

Andy Evans (Lead / Corresponding author), Yee Ting Sim, Celine Pourreyron, Alastair Thompson, Lee Jordan, Dawn Fleming, Colin Purdie, Jane Macaskill, Sarah Vinnicombe, Paul Pharoah

Research output: Contribution to journalArticle

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Abstract

Introduction: With the increased use of neoadjuvant therapy for breast cancer, there is a need for pre-operative prediction of prognosis. We aimed to assess the prognostic value of tumour stiffness measured by ultrasound shear wave elastography (SWE).

Methods: A consecutive cohort of patients with invasive breast cancer underwent breast ultrasound (US) including SWE. The following were recorded prospectively: US diameter, stiffness at SWE, presentation source, core biopsy grade, oestrogen receptor (ER) status and pre-operative nodal status. Breast cancer-specific survival (BCSS) was analysed with regard to US size and stiffness, tumour grade on core biopsy, ER status, presentation mode and pre-operative nodal status. Analysis used Cox proportional hazards regression.

Results: Of the 520 patients, 42 breast cancer and 53 non-breast cancer deaths were recorded at mean follow-up of 5.4 years. Hazard ratios (HR) for tertiles of stiffness were 1, 4.8 and 8.1 (P=0.0001). HR for 2 groups based on US size.
Conclusion: Multiple pre-operative factors including stromal stiffness at SWE have independent prognostic significance. A larger dataset with longer follow-up could be used in the future to construct a pre-operative prognostic model to guide treatment decisions
Original languageEnglish
Pages (from-to)383-389
Number of pages7
JournalBreast Cancer Research and Treatment
Volume171
Issue number2
Early online date1 Jun 2018
DOIs
Publication statusPublished - 1 Jun 2018

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Elasticity Imaging Techniques
Breast Neoplasms
Survival
Biopsy
Neoplasms
Neoadjuvant Therapy
Estrogen Receptors

Keywords

  • Breast cancer
  • Prognosis
  • Shear wave elastography
  • Ultrasound
  • Neoadjuvant chemotherapy

Cite this

Evans, Andy ; Sim, Yee Ting ; Pourreyron, Celine ; Thompson, Alastair ; Jordan, Lee ; Fleming, Dawn ; Purdie, Colin ; Macaskill, Jane ; Vinnicombe, Sarah ; Pharoah, Paul. / Pre-operative stromal stiffness measured by shear wave elastography is independently associated with breast cancer specific survival. In: Breast Cancer Research and Treatment. 2018 ; Vol. 171, No. 2. pp. 383-389.
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abstract = "Introduction: With the increased use of neoadjuvant therapy for breast cancer, there is a need for pre-operative prediction of prognosis. We aimed to assess the prognostic value of tumour stiffness measured by ultrasound shear wave elastography (SWE).Methods: A consecutive cohort of patients with invasive breast cancer underwent breast ultrasound (US) including SWE. The following were recorded prospectively: US diameter, stiffness at SWE, presentation source, core biopsy grade, oestrogen receptor (ER) status and pre-operative nodal status. Breast cancer-specific survival (BCSS) was analysed with regard to US size and stiffness, tumour grade on core biopsy, ER status, presentation mode and pre-operative nodal status. Analysis used Cox proportional hazards regression.Results: Of the 520 patients, 42 breast cancer and 53 non-breast cancer deaths were recorded at mean follow-up of 5.4 years. Hazard ratios (HR) for tertiles of stiffness were 1, 4.8 and 8.1 (P=0.0001). HR for 2 groups based on US size.Conclusion: Multiple pre-operative factors including stromal stiffness at SWE have independent prognostic significance. A larger dataset with longer follow-up could be used in the future to construct a pre-operative prognostic model to guide treatment decisions",
keywords = "Breast cancer, Prognosis, Shear wave elastography, Ultrasound, Neoadjuvant chemotherapy",
author = "Andy Evans and Sim, {Yee Ting} and Celine Pourreyron and Alastair Thompson and Lee Jordan and Dawn Fleming and Colin Purdie and Jane Macaskill and Sarah Vinnicombe and Paul Pharoah",
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Pre-operative stromal stiffness measured by shear wave elastography is independently associated with breast cancer specific survival. / Evans, Andy (Lead / Corresponding author); Sim, Yee Ting; Pourreyron, Celine; Thompson, Alastair; Jordan, Lee; Fleming, Dawn; Purdie, Colin; Macaskill, Jane; Vinnicombe, Sarah; Pharoah, Paul.

In: Breast Cancer Research and Treatment, Vol. 171, No. 2, 01.06.2018, p. 383-389.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Pre-operative stromal stiffness measured by shear wave elastography is independently associated with breast cancer specific survival

AU - Evans, Andy

AU - Sim, Yee Ting

AU - Pourreyron, Celine

AU - Thompson, Alastair

AU - Jordan, Lee

AU - Fleming, Dawn

AU - Purdie, Colin

AU - Macaskill, Jane

AU - Vinnicombe, Sarah

AU - Pharoah, Paul

N1 - Funding: none.

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Introduction: With the increased use of neoadjuvant therapy for breast cancer, there is a need for pre-operative prediction of prognosis. We aimed to assess the prognostic value of tumour stiffness measured by ultrasound shear wave elastography (SWE).Methods: A consecutive cohort of patients with invasive breast cancer underwent breast ultrasound (US) including SWE. The following were recorded prospectively: US diameter, stiffness at SWE, presentation source, core biopsy grade, oestrogen receptor (ER) status and pre-operative nodal status. Breast cancer-specific survival (BCSS) was analysed with regard to US size and stiffness, tumour grade on core biopsy, ER status, presentation mode and pre-operative nodal status. Analysis used Cox proportional hazards regression.Results: Of the 520 patients, 42 breast cancer and 53 non-breast cancer deaths were recorded at mean follow-up of 5.4 years. Hazard ratios (HR) for tertiles of stiffness were 1, 4.8 and 8.1 (P=0.0001). HR for 2 groups based on US size.Conclusion: Multiple pre-operative factors including stromal stiffness at SWE have independent prognostic significance. A larger dataset with longer follow-up could be used in the future to construct a pre-operative prognostic model to guide treatment decisions

AB - Introduction: With the increased use of neoadjuvant therapy for breast cancer, there is a need for pre-operative prediction of prognosis. We aimed to assess the prognostic value of tumour stiffness measured by ultrasound shear wave elastography (SWE).Methods: A consecutive cohort of patients with invasive breast cancer underwent breast ultrasound (US) including SWE. The following were recorded prospectively: US diameter, stiffness at SWE, presentation source, core biopsy grade, oestrogen receptor (ER) status and pre-operative nodal status. Breast cancer-specific survival (BCSS) was analysed with regard to US size and stiffness, tumour grade on core biopsy, ER status, presentation mode and pre-operative nodal status. Analysis used Cox proportional hazards regression.Results: Of the 520 patients, 42 breast cancer and 53 non-breast cancer deaths were recorded at mean follow-up of 5.4 years. Hazard ratios (HR) for tertiles of stiffness were 1, 4.8 and 8.1 (P=0.0001). HR for 2 groups based on US size.Conclusion: Multiple pre-operative factors including stromal stiffness at SWE have independent prognostic significance. A larger dataset with longer follow-up could be used in the future to construct a pre-operative prognostic model to guide treatment decisions

KW - Breast cancer

KW - Prognosis

KW - Shear wave elastography

KW - Ultrasound

KW - Neoadjuvant chemotherapy

U2 - 10.1007/s10549-018-4836-5

DO - 10.1007/s10549-018-4836-5

M3 - Article

VL - 171

SP - 383

EP - 389

JO - Breast Cancer Research and Treatment

JF - Breast Cancer Research and Treatment

SN - 0167-6806

IS - 2

ER -