Predictors of anxiety and depression in people with colorectal cancer

Nicola M. Gray (Lead / Corresponding author), Susan J. Hall, Susan Browne, Marie Johnston, Amanda J. Lee, Una Macleod, Elizabeth D. Mitchell, Leslie Samuel, Neil C. Campbell

    Research output: Contribution to journalArticle

    27 Citations (Scopus)

    Abstract

    BACKGROUND: People living with colorectal cancer are at risk of anxiety and depression. We investigated what factors were most highly associated with these.

    METHODS: Four hundred and ninety-six people with colorectal cancer completed the Hospital Anxiety and Depression Scale (HADS). Data on functioning, symptoms, illness perceptions and social difficulties were collected by questionnaire. Case-note-identified disease, treatment and co-morbidity data were recorded. Multiple logistic regression identified factors independently predictive of anxiety and depression caseness.

    RESULTS: Self-reported history of anxiety/depression predicted anxiety but not depression caseness. Depression caseness predicted anxiety caseness (p = 0.043), as did poorer self-reported cognitive functioning (p = 0.001), dyspnoea (p = 0.015) or diarrhoea (p = 0.021), reporting a high negative life and emotional impact (p < 0.001) and having difficulties with finance (p = 0.007). Having neo-adjuvant radiotherapy increased the odds of depression caseness (p = 0.007), as did poorer physical (p = 0.007), cognitive (p < 0.001) and social (p < 0.001) functioning, having constipation (p = 0.011), reporting a high negative life and emotional impact (p < 0.001), having difficulties with personal care (p = 0.022) and communicating with others (p = 0.014).

    CONCLUSION: Levels of anxiety caseness were similar to those of non-clinical samples, but depression caseness was higher, particularly in those who had received neo-adjuvant radiotherapy. Most factors associated with possible or probable depression may be modified with appropriate intervention.

    Original languageEnglish
    Pages (from-to)307-314
    Number of pages8
    JournalSupportive Care in Cancer
    Volume22
    Issue number2
    DOIs
    Publication statusPublished - Feb 2014

    Fingerprint

    Colorectal Neoplasms
    Anxiety
    Depression
    Adjuvant Radiotherapy
    Social Perception
    Cancer Care Facilities
    Constipation
    Dyspnea
    Diarrhea
    Logistic Models
    Morbidity

    Keywords

    • Anxiety
    • Colorectal neoplasms
    • Depression
    • Female
    • Humans
    • Male
    • Middle aged
    • Psychiatric status rating scales
    • Surveys and questionnaires

    Cite this

    Gray, N. M., Hall, S. J., Browne, S., Johnston, M., Lee, A. J., Macleod, U., ... Campbell, N. C. (2014). Predictors of anxiety and depression in people with colorectal cancer. Supportive Care in Cancer, 22(2), 307-314. https://doi.org/10.1007/s00520-013-1963-8
    Gray, Nicola M. ; Hall, Susan J. ; Browne, Susan ; Johnston, Marie ; Lee, Amanda J. ; Macleod, Una ; Mitchell, Elizabeth D. ; Samuel, Leslie ; Campbell, Neil C. / Predictors of anxiety and depression in people with colorectal cancer. In: Supportive Care in Cancer. 2014 ; Vol. 22, No. 2. pp. 307-314.
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    abstract = "BACKGROUND: People living with colorectal cancer are at risk of anxiety and depression. We investigated what factors were most highly associated with these.METHODS: Four hundred and ninety-six people with colorectal cancer completed the Hospital Anxiety and Depression Scale (HADS). Data on functioning, symptoms, illness perceptions and social difficulties were collected by questionnaire. Case-note-identified disease, treatment and co-morbidity data were recorded. Multiple logistic regression identified factors independently predictive of anxiety and depression caseness.RESULTS: Self-reported history of anxiety/depression predicted anxiety but not depression caseness. Depression caseness predicted anxiety caseness (p = 0.043), as did poorer self-reported cognitive functioning (p = 0.001), dyspnoea (p = 0.015) or diarrhoea (p = 0.021), reporting a high negative life and emotional impact (p < 0.001) and having difficulties with finance (p = 0.007). Having neo-adjuvant radiotherapy increased the odds of depression caseness (p = 0.007), as did poorer physical (p = 0.007), cognitive (p < 0.001) and social (p < 0.001) functioning, having constipation (p = 0.011), reporting a high negative life and emotional impact (p < 0.001), having difficulties with personal care (p = 0.022) and communicating with others (p = 0.014).CONCLUSION: Levels of anxiety caseness were similar to those of non-clinical samples, but depression caseness was higher, particularly in those who had received neo-adjuvant radiotherapy. Most factors associated with possible or probable depression may be modified with appropriate intervention.",
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    Gray, NM, Hall, SJ, Browne, S, Johnston, M, Lee, AJ, Macleod, U, Mitchell, ED, Samuel, L & Campbell, NC 2014, 'Predictors of anxiety and depression in people with colorectal cancer', Supportive Care in Cancer, vol. 22, no. 2, pp. 307-314. https://doi.org/10.1007/s00520-013-1963-8

    Predictors of anxiety and depression in people with colorectal cancer. / Gray, Nicola M. (Lead / Corresponding author); Hall, Susan J.; Browne, Susan; Johnston, Marie; Lee, Amanda J.; Macleod, Una; Mitchell, Elizabeth D.; Samuel, Leslie; Campbell, Neil C.

    In: Supportive Care in Cancer, Vol. 22, No. 2, 02.2014, p. 307-314.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Predictors of anxiety and depression in people with colorectal cancer

    AU - Gray, Nicola M.

    AU - Hall, Susan J.

    AU - Browne, Susan

    AU - Johnston, Marie

    AU - Lee, Amanda J.

    AU - Macleod, Una

    AU - Mitchell, Elizabeth D.

    AU - Samuel, Leslie

    AU - Campbell, Neil C.

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    N2 - BACKGROUND: People living with colorectal cancer are at risk of anxiety and depression. We investigated what factors were most highly associated with these.METHODS: Four hundred and ninety-six people with colorectal cancer completed the Hospital Anxiety and Depression Scale (HADS). Data on functioning, symptoms, illness perceptions and social difficulties were collected by questionnaire. Case-note-identified disease, treatment and co-morbidity data were recorded. Multiple logistic regression identified factors independently predictive of anxiety and depression caseness.RESULTS: Self-reported history of anxiety/depression predicted anxiety but not depression caseness. Depression caseness predicted anxiety caseness (p = 0.043), as did poorer self-reported cognitive functioning (p = 0.001), dyspnoea (p = 0.015) or diarrhoea (p = 0.021), reporting a high negative life and emotional impact (p < 0.001) and having difficulties with finance (p = 0.007). Having neo-adjuvant radiotherapy increased the odds of depression caseness (p = 0.007), as did poorer physical (p = 0.007), cognitive (p < 0.001) and social (p < 0.001) functioning, having constipation (p = 0.011), reporting a high negative life and emotional impact (p < 0.001), having difficulties with personal care (p = 0.022) and communicating with others (p = 0.014).CONCLUSION: Levels of anxiety caseness were similar to those of non-clinical samples, but depression caseness was higher, particularly in those who had received neo-adjuvant radiotherapy. Most factors associated with possible or probable depression may be modified with appropriate intervention.

    AB - BACKGROUND: People living with colorectal cancer are at risk of anxiety and depression. We investigated what factors were most highly associated with these.METHODS: Four hundred and ninety-six people with colorectal cancer completed the Hospital Anxiety and Depression Scale (HADS). Data on functioning, symptoms, illness perceptions and social difficulties were collected by questionnaire. Case-note-identified disease, treatment and co-morbidity data were recorded. Multiple logistic regression identified factors independently predictive of anxiety and depression caseness.RESULTS: Self-reported history of anxiety/depression predicted anxiety but not depression caseness. Depression caseness predicted anxiety caseness (p = 0.043), as did poorer self-reported cognitive functioning (p = 0.001), dyspnoea (p = 0.015) or diarrhoea (p = 0.021), reporting a high negative life and emotional impact (p < 0.001) and having difficulties with finance (p = 0.007). Having neo-adjuvant radiotherapy increased the odds of depression caseness (p = 0.007), as did poorer physical (p = 0.007), cognitive (p < 0.001) and social (p < 0.001) functioning, having constipation (p = 0.011), reporting a high negative life and emotional impact (p < 0.001), having difficulties with personal care (p = 0.022) and communicating with others (p = 0.014).CONCLUSION: Levels of anxiety caseness were similar to those of non-clinical samples, but depression caseness was higher, particularly in those who had received neo-adjuvant radiotherapy. Most factors associated with possible or probable depression may be modified with appropriate intervention.

    KW - Anxiety

    KW - Colorectal neoplasms

    KW - Depression

    KW - Female

    KW - Humans

    KW - Male

    KW - Middle aged

    KW - Psychiatric status rating scales

    KW - Surveys and questionnaires

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    DO - 10.1007/s00520-013-1963-8

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