Protect us from poor-quality medical research

ESHRE Capri Workshop Group

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Much of the published medical research is apparently flawed, cannot be replicated and/or has limited or no utility. This article presents an overview of the current landscape of biomedical research, identifies problems associated with common study designs and considers potential solutions. Randomized clinical trials, observational studies, systematic reviews and meta-analyses are discussed in terms of their inherent limitations and potential ways of improving their conduct, analysis and reporting. The current emphasis on statistical significance needs to be replaced by sound design, transparency and willingness to share data with a clear commitment towards improving the quality and utility of clinical research.

Original languageEnglish
Pages (from-to)770-776
Number of pages7
JournalHuman Reproduction
Volume33
Issue number5
Early online date29 Mar 2018
DOIs
Publication statusPublished - 1 May 2018

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Biomedical Research
Observational Studies
Meta-Analysis
Randomized Controlled Trials
Research

Keywords

  • equipose
  • medical research
  • meta-analysis
  • P -value
  • randomized clinical trial

Cite this

ESHRE Capri Workshop Group. / Protect us from poor-quality medical research. In: Human Reproduction. 2018 ; Vol. 33, No. 5. pp. 770-776.
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abstract = "Much of the published medical research is apparently flawed, cannot be replicated and/or has limited or no utility. This article presents an overview of the current landscape of biomedical research, identifies problems associated with common study designs and considers potential solutions. Randomized clinical trials, observational studies, systematic reviews and meta-analyses are discussed in terms of their inherent limitations and potential ways of improving their conduct, analysis and reporting. The current emphasis on statistical significance needs to be replaced by sound design, transparency and willingness to share data with a clear commitment towards improving the quality and utility of clinical research.",
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author = "{ESHRE Capri Workshop Group} and Ioannidis, {John P.A.} and Siladitya Bhattacharya and Evers, {J. L.H.} and {Der Veen}, {Fulco Van} and Edgardo Somigliana and Barratt, {Christopher L.R.} and Gianluca Bontempi and Baird, {David T.} and Piergiorgio Crosignani and Paul Devroey and Klaus Diedrich and Farquharson, {Roy G.} and Fraser, {Lynn R.} and Geraedts, {Joep P.M.} and Luca Gianaroli and {La Vecchia}, Carlo and Cristina Magli and Eva Negri and Arne Sunde and Tapanainen, {Juha S.} and Tarlatzis, {Basil C.} and Steirteghem, {Andre Van} and Anna Veiga",
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ESHRE Capri Workshop Group 2018, 'Protect us from poor-quality medical research', Human Reproduction, vol. 33, no. 5, pp. 770-776. https://doi.org/10.1093/humrep/dey056

Protect us from poor-quality medical research. / ESHRE Capri Workshop Group.

In: Human Reproduction, Vol. 33, No. 5, 01.05.2018, p. 770-776.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Protect us from poor-quality medical research

AU - ESHRE Capri Workshop Group

AU - Ioannidis, John P.A.

AU - Bhattacharya, Siladitya

AU - Evers, J. L.H.

AU - Der Veen, Fulco Van

AU - Somigliana, Edgardo

AU - Barratt, Christopher L.R.

AU - Bontempi, Gianluca

AU - Baird, David T.

AU - Crosignani, Piergiorgio

AU - Devroey, Paul

AU - Diedrich, Klaus

AU - Farquharson, Roy G.

AU - Fraser, Lynn R.

AU - Geraedts, Joep P.M.

AU - Gianaroli, Luca

AU - La Vecchia, Carlo

AU - Magli, Cristina

AU - Negri, Eva

AU - Sunde, Arne

AU - Tapanainen, Juha S.

AU - Tarlatzis, Basil C.

AU - Steirteghem, Andre Van

AU - Veiga, Anna

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Much of the published medical research is apparently flawed, cannot be replicated and/or has limited or no utility. This article presents an overview of the current landscape of biomedical research, identifies problems associated with common study designs and considers potential solutions. Randomized clinical trials, observational studies, systematic reviews and meta-analyses are discussed in terms of their inherent limitations and potential ways of improving their conduct, analysis and reporting. The current emphasis on statistical significance needs to be replaced by sound design, transparency and willingness to share data with a clear commitment towards improving the quality and utility of clinical research.

AB - Much of the published medical research is apparently flawed, cannot be replicated and/or has limited or no utility. This article presents an overview of the current landscape of biomedical research, identifies problems associated with common study designs and considers potential solutions. Randomized clinical trials, observational studies, systematic reviews and meta-analyses are discussed in terms of their inherent limitations and potential ways of improving their conduct, analysis and reporting. The current emphasis on statistical significance needs to be replaced by sound design, transparency and willingness to share data with a clear commitment towards improving the quality and utility of clinical research.

KW - equipose

KW - medical research

KW - meta-analysis

KW - P -value

KW - randomized clinical trial

U2 - 10.1093/humrep/dey056

DO - 10.1093/humrep/dey056

M3 - Article

C2 - 29617882

AN - SCOPUS:85046942537

VL - 33

SP - 770

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JO - Human Reproduction

JF - Human Reproduction

SN - 0268-1161

IS - 5

ER -