Quantitative evaluation of degenerated tendon model using combined optical coherence elastography and acoustic radiation force method

Guangying Guan, Chunhui Li, Yuting Ling, Ying Yang, Jan B. Vorstius, Robert P. Keatch, Ruikang K. Wang, Zhihong Huang

    Research output: Contribution to journalArticle

    25 Citations (Scopus)

    Abstract

    ABSTRACT. Damage of collagen fibers in tendons is often directly related to changes in a tendon's mechanical properties. Direct quantitative elasticity measurement of tendons will provide important information in tendon dysfunction diagnosis and treatment assessment. A feasibility study of quantifying the mechanical properties of a degenerated tendon model by a nondestructive imaging modality, which combines optical coherence elastography and acoustic radiation force (ARF) method, is presented. The degenerated tendon model was produced by the partial degradation of chicken tendons through incubation with collagenase at different concentrations and incubation times. A 30-kHz longitudinal ultrasound transducer was used to provide an ARF signal, which was detected by an ultra-high sensitive phase sensitive optical coherence tomography (PhS-OCT) system. The experimental results demonstrate that the combination of ARF method and PhS-OCT can measure the elasticity of tendon quantitatively. The corresponding changes in tendon elasticity due to the application of collagenase have been revealed by this new imaging modality. This method can potentially be used in the assessment of tissue engineering products and in the diagnosis and treatment progression of tendon diseases.
    Original languageEnglish
    Article number111417
    JournalJournal of Biomedical Optics
    Volume18
    Issue number11
    DOIs
    Publication statusPublished - Nov 2013

    Fingerprint

    tendons
    Tendons
    sound waves
    Acoustics
    Radiation
    evaluation
    radiation
    Elasticity
    elastic properties
    Optical tomography
    Collagenases
    tomography
    mechanical properties
    Imaging techniques
    Mechanical properties
    chickens
    tissue engineering
    collagens
    Tissue engineering
    Collagen

    Cite this

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    title = "Quantitative evaluation of degenerated tendon model using combined optical coherence elastography and acoustic radiation force method",
    abstract = "ABSTRACT. Damage of collagen fibers in tendons is often directly related to changes in a tendon's mechanical properties. Direct quantitative elasticity measurement of tendons will provide important information in tendon dysfunction diagnosis and treatment assessment. A feasibility study of quantifying the mechanical properties of a degenerated tendon model by a nondestructive imaging modality, which combines optical coherence elastography and acoustic radiation force (ARF) method, is presented. The degenerated tendon model was produced by the partial degradation of chicken tendons through incubation with collagenase at different concentrations and incubation times. A 30-kHz longitudinal ultrasound transducer was used to provide an ARF signal, which was detected by an ultra-high sensitive phase sensitive optical coherence tomography (PhS-OCT) system. The experimental results demonstrate that the combination of ARF method and PhS-OCT can measure the elasticity of tendon quantitatively. The corresponding changes in tendon elasticity due to the application of collagenase have been revealed by this new imaging modality. This method can potentially be used in the assessment of tissue engineering products and in the diagnosis and treatment progression of tendon diseases.",
    author = "Guangying Guan and Chunhui Li and Yuting Ling and Ying Yang and Vorstius, {Jan B.} and Keatch, {Robert P.} and Wang, {Ruikang K.} and Zhihong Huang",
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    language = "English",
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    Quantitative evaluation of degenerated tendon model using combined optical coherence elastography and acoustic radiation force method. / Guan, Guangying; Li, Chunhui; Ling, Yuting; Yang, Ying; Vorstius, Jan B.; Keatch, Robert P.; Wang, Ruikang K.; Huang, Zhihong.

    In: Journal of Biomedical Optics, Vol. 18, No. 11, 111417, 11.2013.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Quantitative evaluation of degenerated tendon model using combined optical coherence elastography and acoustic radiation force method

    AU - Guan, Guangying

    AU - Li, Chunhui

    AU - Ling, Yuting

    AU - Yang, Ying

    AU - Vorstius, Jan B.

    AU - Keatch, Robert P.

    AU - Wang, Ruikang K.

    AU - Huang, Zhihong

    PY - 2013/11

    Y1 - 2013/11

    N2 - ABSTRACT. Damage of collagen fibers in tendons is often directly related to changes in a tendon's mechanical properties. Direct quantitative elasticity measurement of tendons will provide important information in tendon dysfunction diagnosis and treatment assessment. A feasibility study of quantifying the mechanical properties of a degenerated tendon model by a nondestructive imaging modality, which combines optical coherence elastography and acoustic radiation force (ARF) method, is presented. The degenerated tendon model was produced by the partial degradation of chicken tendons through incubation with collagenase at different concentrations and incubation times. A 30-kHz longitudinal ultrasound transducer was used to provide an ARF signal, which was detected by an ultra-high sensitive phase sensitive optical coherence tomography (PhS-OCT) system. The experimental results demonstrate that the combination of ARF method and PhS-OCT can measure the elasticity of tendon quantitatively. The corresponding changes in tendon elasticity due to the application of collagenase have been revealed by this new imaging modality. This method can potentially be used in the assessment of tissue engineering products and in the diagnosis and treatment progression of tendon diseases.

    AB - ABSTRACT. Damage of collagen fibers in tendons is often directly related to changes in a tendon's mechanical properties. Direct quantitative elasticity measurement of tendons will provide important information in tendon dysfunction diagnosis and treatment assessment. A feasibility study of quantifying the mechanical properties of a degenerated tendon model by a nondestructive imaging modality, which combines optical coherence elastography and acoustic radiation force (ARF) method, is presented. The degenerated tendon model was produced by the partial degradation of chicken tendons through incubation with collagenase at different concentrations and incubation times. A 30-kHz longitudinal ultrasound transducer was used to provide an ARF signal, which was detected by an ultra-high sensitive phase sensitive optical coherence tomography (PhS-OCT) system. The experimental results demonstrate that the combination of ARF method and PhS-OCT can measure the elasticity of tendon quantitatively. The corresponding changes in tendon elasticity due to the application of collagenase have been revealed by this new imaging modality. This method can potentially be used in the assessment of tissue engineering products and in the diagnosis and treatment progression of tendon diseases.

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