Reaction-diffusion pre-patterning and its potential role in tumour invasion

M. A. J. Chaplain

    Research output: Contribution to journalArticle

    Abstract

    The growth of a solid tumour proceeds through two distinct phases: the avascular phase and the vascular phase. It is during the latter that the insidious process of invasion of surrounding tissues can and does take place. Once vascularized the tumours grow rapidly as exophytic masses. In certain types of cancer, e.g. carcinoma arising within an organ, this process typically consists of columns of cells projecting from the central mass of cells and extending into the surrounding tissue area. The local spread of these carcinoma often assume an irregular jagged shape. Experimental results have demonstrated that tumour cells secrete both growth-activating and growth-inhibiting chemicals. Using this knowledge a pre-pattern theory of cancer cell invasion is proposed. The theoretical results are compared with experimental and clinical results regarding the heterogeneity of cancer cells within multicell spheroids and the well-known invasion characteristics of carcinoma.
    Original languageEnglish
    Pages (from-to)929-936
    Number of pages8
    JournalJournal of Biological Systems
    Volume3
    Issue number4
    DOIs
    Publication statusPublished - 1995

    Fingerprint

    Invasion
    Reaction-diffusion
    Patterning
    tumor
    carcinoma
    Tumors
    Tumor
    cancer
    Cells
    neoplasms
    Cell
    Cancer
    Tissue
    Neoplasms
    cell invasion
    Carcinoma
    blood vessels
    Growth
    cells
    Irregular

    Keywords

    • Reaction-diffusion
    • Tumour invasion of tissue

    Cite this

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    abstract = "The growth of a solid tumour proceeds through two distinct phases: the avascular phase and the vascular phase. It is during the latter that the insidious process of invasion of surrounding tissues can and does take place. Once vascularized the tumours grow rapidly as exophytic masses. In certain types of cancer, e.g. carcinoma arising within an organ, this process typically consists of columns of cells projecting from the central mass of cells and extending into the surrounding tissue area. The local spread of these carcinoma often assume an irregular jagged shape. Experimental results have demonstrated that tumour cells secrete both growth-activating and growth-inhibiting chemicals. Using this knowledge a pre-pattern theory of cancer cell invasion is proposed. The theoretical results are compared with experimental and clinical results regarding the heterogeneity of cancer cells within multicell spheroids and the well-known invasion characteristics of carcinoma.",
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    Reaction-diffusion pre-patterning and its potential role in tumour invasion. / Chaplain, M. A. J.

    In: Journal of Biological Systems, Vol. 3, No. 4, 1995, p. 929-936.

    Research output: Contribution to journalArticle

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    AB - The growth of a solid tumour proceeds through two distinct phases: the avascular phase and the vascular phase. It is during the latter that the insidious process of invasion of surrounding tissues can and does take place. Once vascularized the tumours grow rapidly as exophytic masses. In certain types of cancer, e.g. carcinoma arising within an organ, this process typically consists of columns of cells projecting from the central mass of cells and extending into the surrounding tissue area. The local spread of these carcinoma often assume an irregular jagged shape. Experimental results have demonstrated that tumour cells secrete both growth-activating and growth-inhibiting chemicals. Using this knowledge a pre-pattern theory of cancer cell invasion is proposed. The theoretical results are compared with experimental and clinical results regarding the heterogeneity of cancer cells within multicell spheroids and the well-known invasion characteristics of carcinoma.

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