Relationship between the gstm1 genetic polymorphism and susceptibility to bladder, breast and colon cancer

S. Zhong, A. H. Wyllie, D. Barnes, C. R. Wolf (Lead / Corresponding author), N. K. Spurr

    Research output: Contribution to journalArticle

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    Abstract

    Mammalian cytosolic glutathione S-transferases (GSTs; EC 2.5.1.18) form a supergene family consisting of four distinct families, named alpha, mu, pi and theta. In humans one member of the mu class gene family (GSTM1) has been shown to be polymorphic and is only expressed in 55-60% of individuals. Previous studies have shown a possible link with the null phenotype and susceptibility to cancer, in particular to lung cancer. In this study we genotyped individuals with breast, bladder and colorectal cancer. A total of 490 individuals with cancer were studied, and consisted of 97 bladder, 197 breast and 196 colorectal cancers. No significant differences were observed in the frequency of nulled individuals in bladder or breast cancer patients when compared with a control population of 225 individuals. However, a significant excess of nulled individuals were seen in colorectal cancer: 56.1% compared with the control group value of 41.8%. This was shown to be highly significant depending on the site of the tumours and >70% of individuals with a tumour in the proximal colon were GSTM1 nulled. This is an ∼2-fold increase in colon cancer risk in these individuals.

    Original languageEnglish
    Pages (from-to)1821-1824
    Number of pages4
    JournalCarcinogenesis
    Volume14
    Issue number9
    DOIs
    Publication statusPublished - 1 Sep 1993

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    Genetic Polymorphisms
    Genetic Predisposition to Disease
    Urinary Bladder Neoplasms
    Colonic Neoplasms
    Breast Neoplasms
    Colorectal Neoplasms
    Neoplasms
    Glutathione Transferase
    Lung Neoplasms
    Colon
    Urinary Bladder
    Breast
    Phenotype
    Control Groups
    Population
    Genes

    Cite this

    Zhong, S. ; Wyllie, A. H. ; Barnes, D. ; Wolf, C. R. ; Spurr, N. K. / Relationship between the gstm1 genetic polymorphism and susceptibility to bladder, breast and colon cancer. In: Carcinogenesis. 1993 ; Vol. 14, No. 9. pp. 1821-1824.
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    Relationship between the gstm1 genetic polymorphism and susceptibility to bladder, breast and colon cancer. / Zhong, S.; Wyllie, A. H.; Barnes, D.; Wolf, C. R. (Lead / Corresponding author); Spurr, N. K.

    In: Carcinogenesis, Vol. 14, No. 9, 01.09.1993, p. 1821-1824.

    Research output: Contribution to journalArticle

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