Replication licensing and cancer -

a fatal entanglement?

    Research output: Contribution to journalReview article

    149 Citations (Scopus)

    Abstract

    Correct regulation of the replication licensing system ensures that chromosomal DNA is precisely duplicated in each cell division cycle. Licensing proteins are inappropriately expressed at an early stage of tumorigenesis in a wide variety of cancers. Here we discuss evidence that misregulation of replication licensing is a consequence of oncogene-induced cell proliferation. This misregulation can cause either under-or over-replication of chromosomal DNA, and could explain the genetic instability commonly seen in cancer cells.

    Original languageEnglish
    Pages (from-to)799-806
    Number of pages8
    JournalNature Reviews Cancer
    Volume8
    Issue number10
    DOIs
    Publication statusPublished - Oct 2008

    Keywords

    • Animals
    • Cell Cycle Proteins
    • Cell Transformation, Neoplastic
    • DNA Damage
    • DNA Replication
    • Humans
    • Mice
    • Neoplasms
    • Nuclear Proteins

    Cite this

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    title = "Replication licensing and cancer -: a fatal entanglement?",
    abstract = "Correct regulation of the replication licensing system ensures that chromosomal DNA is precisely duplicated in each cell division cycle. Licensing proteins are inappropriately expressed at an early stage of tumorigenesis in a wide variety of cancers. Here we discuss evidence that misregulation of replication licensing is a consequence of oncogene-induced cell proliferation. This misregulation can cause either under-or over-replication of chromosomal DNA, and could explain the genetic instability commonly seen in cancer cells.",
    keywords = "Animals, Cell Cycle Proteins, Cell Transformation, Neoplastic, DNA Damage, DNA Replication, Humans, Mice, Neoplasms, Nuclear Proteins",
    author = "Blow, {J. Julian} and Gillespie, {Peter J.}",
    year = "2008",
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    pages = "799--806",
    journal = "Nature Reviews Cancer",
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    }

    Replication licensing and cancer - : a fatal entanglement? / Blow, J. Julian; Gillespie, Peter J.

    In: Nature Reviews Cancer, Vol. 8, No. 10, 10.2008, p. 799-806.

    Research output: Contribution to journalReview article

    TY - JOUR

    T1 - Replication licensing and cancer -

    T2 - a fatal entanglement?

    AU - Blow, J. Julian

    AU - Gillespie, Peter J.

    PY - 2008/10

    Y1 - 2008/10

    N2 - Correct regulation of the replication licensing system ensures that chromosomal DNA is precisely duplicated in each cell division cycle. Licensing proteins are inappropriately expressed at an early stage of tumorigenesis in a wide variety of cancers. Here we discuss evidence that misregulation of replication licensing is a consequence of oncogene-induced cell proliferation. This misregulation can cause either under-or over-replication of chromosomal DNA, and could explain the genetic instability commonly seen in cancer cells.

    AB - Correct regulation of the replication licensing system ensures that chromosomal DNA is precisely duplicated in each cell division cycle. Licensing proteins are inappropriately expressed at an early stage of tumorigenesis in a wide variety of cancers. Here we discuss evidence that misregulation of replication licensing is a consequence of oncogene-induced cell proliferation. This misregulation can cause either under-or over-replication of chromosomal DNA, and could explain the genetic instability commonly seen in cancer cells.

    KW - Animals

    KW - Cell Cycle Proteins

    KW - Cell Transformation, Neoplastic

    KW - DNA Damage

    KW - DNA Replication

    KW - Humans

    KW - Mice

    KW - Neoplasms

    KW - Nuclear Proteins

    U2 - 10.1038/nrc2500

    DO - 10.1038/nrc2500

    M3 - Review article

    VL - 8

    SP - 799

    EP - 806

    JO - Nature Reviews Cancer

    JF - Nature Reviews Cancer

    SN - 1474-175X

    IS - 10

    ER -