Small vessels, dementia and chronic diseases

molecular mechanisms and pathophysiology

Karen Horsburgh, Joanna M. Wardlaw, Tom van Agtmael, Stuart M. Allan, Mike L.J. Ashford, Philip M. Bath, Rosalind Brown, Jason Berwick, M. Zameel Cader, Roxana O. Carare, John B. Davis, Jessica Duncombe, Tracy D. Farr, Jill H. Fowler, Jozien Goense, Alessandra Granata, Catherine N. Hall, Atticus H. Hainsworth, Adam Harvey, Cheryl A. Hawkes & 26 others Anne Joutel, Rajesh N. Kalaria, Patrick G. Kehoe, Catherine B. Lawrence, Andy Lockhart, Seth Love, Malcolm R. Macleod, I. Mhairi Macrae, Hugh S. Markus, Chris McCabe, Barry W. McColl, Paul J. Meakin, Alyson Miller, Maiken Nedergaard, Michael O'Sullivan, Terry J. Quinn, Rikesh Rajani, Lisa M. Saksida, Colin Smith, Kenneth J. Smith, Rhian M. Touyz, Rebecca C. Trueman, Tao Wang, Anna Williams, Steven C.R. Williams, Lorraine M. Work

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Cerebral small vessel disease (SVD) is a major contributor to stroke, cognitive impairment and dementia with limited therapeutic interventions. There is a critical need to provide mechanistic insight and improve translation between pre-clinical research and the clinic. A 2-day workshop was held which brought together experts from several disciplines in cerebrovascular disease, dementia and cardiovascular biology, to highlight current advances in these fields, explore synergies and scope for development. These proceedings provide a summary of key talks at the workshop with a particular focus on animal models of cerebral vascular disease and dementia, mechanisms and approaches to improve translation. The outcomes of discussion groups on related themes to identify the gaps in knowledge and requirements to advance knowledge are summarized.

Original languageEnglish
Pages (from-to)851-868
Number of pages18
JournalClinical Science
Volume132
Issue number8
Early online date30 Apr 2018
DOIs
Publication statusE-pub ahead of print - 30 Apr 2018

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Dementia
Chronic Disease
Cerebral Small Vessel Diseases
Education
Cerebrovascular Disorders
Vascular Dementia
Vascular Diseases
Animal Models
Stroke
Research
Therapeutics
Cognitive Dysfunction

Cite this

Horsburgh, K., Wardlaw, J. M., van Agtmael, T., Allan, S. M., Ashford, M. L. J., Bath, P. M., ... Work, L. M. (2018). Small vessels, dementia and chronic diseases: molecular mechanisms and pathophysiology. Clinical Science, 132(8), 851-868. https://doi.org/10.1042/CS20171620
Horsburgh, Karen ; Wardlaw, Joanna M. ; van Agtmael, Tom ; Allan, Stuart M. ; Ashford, Mike L.J. ; Bath, Philip M. ; Brown, Rosalind ; Berwick, Jason ; Cader, M. Zameel ; Carare, Roxana O. ; Davis, John B. ; Duncombe, Jessica ; Farr, Tracy D. ; Fowler, Jill H. ; Goense, Jozien ; Granata, Alessandra ; Hall, Catherine N. ; Hainsworth, Atticus H. ; Harvey, Adam ; Hawkes, Cheryl A. ; Joutel, Anne ; Kalaria, Rajesh N. ; Kehoe, Patrick G. ; Lawrence, Catherine B. ; Lockhart, Andy ; Love, Seth ; Macleod, Malcolm R. ; Macrae, I. Mhairi ; Markus, Hugh S. ; McCabe, Chris ; McColl, Barry W. ; Meakin, Paul J. ; Miller, Alyson ; Nedergaard, Maiken ; O'Sullivan, Michael ; Quinn, Terry J. ; Rajani, Rikesh ; Saksida, Lisa M. ; Smith, Colin ; Smith, Kenneth J. ; Touyz, Rhian M. ; Trueman, Rebecca C. ; Wang, Tao ; Williams, Anna ; Williams, Steven C.R. ; Work, Lorraine M. / Small vessels, dementia and chronic diseases : molecular mechanisms and pathophysiology. In: Clinical Science. 2018 ; Vol. 132, No. 8. pp. 851-868.
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Horsburgh, K, Wardlaw, JM, van Agtmael, T, Allan, SM, Ashford, MLJ, Bath, PM, Brown, R, Berwick, J, Cader, MZ, Carare, RO, Davis, JB, Duncombe, J, Farr, TD, Fowler, JH, Goense, J, Granata, A, Hall, CN, Hainsworth, AH, Harvey, A, Hawkes, CA, Joutel, A, Kalaria, RN, Kehoe, PG, Lawrence, CB, Lockhart, A, Love, S, Macleod, MR, Macrae, IM, Markus, HS, McCabe, C, McColl, BW, Meakin, PJ, Miller, A, Nedergaard, M, O'Sullivan, M, Quinn, TJ, Rajani, R, Saksida, LM, Smith, C, Smith, KJ, Touyz, RM, Trueman, RC, Wang, T, Williams, A, Williams, SCR & Work, LM 2018, 'Small vessels, dementia and chronic diseases: molecular mechanisms and pathophysiology', Clinical Science, vol. 132, no. 8, pp. 851-868. https://doi.org/10.1042/CS20171620

Small vessels, dementia and chronic diseases : molecular mechanisms and pathophysiology. / Horsburgh, Karen; Wardlaw, Joanna M.; van Agtmael, Tom; Allan, Stuart M.; Ashford, Mike L.J.; Bath, Philip M.; Brown, Rosalind; Berwick, Jason; Cader, M. Zameel; Carare, Roxana O.; Davis, John B.; Duncombe, Jessica; Farr, Tracy D.; Fowler, Jill H.; Goense, Jozien; Granata, Alessandra; Hall, Catherine N.; Hainsworth, Atticus H.; Harvey, Adam; Hawkes, Cheryl A.; Joutel, Anne; Kalaria, Rajesh N.; Kehoe, Patrick G.; Lawrence, Catherine B.; Lockhart, Andy; Love, Seth; Macleod, Malcolm R.; Macrae, I. Mhairi; Markus, Hugh S.; McCabe, Chris; McColl, Barry W.; Meakin, Paul J.; Miller, Alyson; Nedergaard, Maiken; O'Sullivan, Michael; Quinn, Terry J.; Rajani, Rikesh; Saksida, Lisa M.; Smith, Colin; Smith, Kenneth J.; Touyz, Rhian M.; Trueman, Rebecca C.; Wang, Tao; Williams, Anna; Williams, Steven C.R.; Work, Lorraine M.

In: Clinical Science, Vol. 132, No. 8, 30.04.2018, p. 851-868.

Research output: Contribution to journalArticle

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T1 - Small vessels, dementia and chronic diseases

T2 - molecular mechanisms and pathophysiology

AU - Horsburgh, Karen

AU - Wardlaw, Joanna M.

AU - van Agtmael, Tom

AU - Allan, Stuart M.

AU - Ashford, Mike L.J.

AU - Bath, Philip M.

AU - Brown, Rosalind

AU - Berwick, Jason

AU - Cader, M. Zameel

AU - Carare, Roxana O.

AU - Davis, John B.

AU - Duncombe, Jessica

AU - Farr, Tracy D.

AU - Fowler, Jill H.

AU - Goense, Jozien

AU - Granata, Alessandra

AU - Hall, Catherine N.

AU - Hainsworth, Atticus H.

AU - Harvey, Adam

AU - Hawkes, Cheryl A.

AU - Joutel, Anne

AU - Kalaria, Rajesh N.

AU - Kehoe, Patrick G.

AU - Lawrence, Catherine B.

AU - Lockhart, Andy

AU - Love, Seth

AU - Macleod, Malcolm R.

AU - Macrae, I. Mhairi

AU - Markus, Hugh S.

AU - McCabe, Chris

AU - McColl, Barry W.

AU - Meakin, Paul J.

AU - Miller, Alyson

AU - Nedergaard, Maiken

AU - O'Sullivan, Michael

AU - Quinn, Terry J.

AU - Rajani, Rikesh

AU - Saksida, Lisa M.

AU - Smith, Colin

AU - Smith, Kenneth J.

AU - Touyz, Rhian M.

AU - Trueman, Rebecca C.

AU - Wang, Tao

AU - Williams, Anna

AU - Williams, Steven C.R.

AU - Work, Lorraine M.

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