Spectroscopic characterisation and manipulation of arrays of sub-picolitre aerosol droplets

Jason R. Butler, Jon B. Wills, Laura Mitchem, Daniel R. Burnham, David McGloin, Jonathan P. Reid

    Research output: Contribution to journalArticle

    30 Citations (Scopus)

    Abstract

    Arrays of optically tweezed aerosol droplets, each of sub-picolitre volume, are manipulated by holographic optical tweezers and characterised by cavity enhanced Raman spectroscopy. A spatial light modulator is employed to generate arrays of optical traps from a single laser beam and to control the array dimensions and relative trap positions. Comparative hygroscopicity measurements are performed concurrently on five trapped droplets by monitoring the evolving size of each droplet. This is extended to the controlled coalescence of an array of droplets accompanied by spectroscopic measurements. These data represent the first ever simultaneous measurements of the evolving composition and size of an array of aerosol droplets. We consider the possibility of using aerosol arrays as a platform for studying chemical reactions in sub-picolitre volumes, exploiting the versatility of aerosol arrays for performing optical digital microfluidic operations accompanied by micro-total analysis.

    Original languageEnglish
    Pages (from-to)521-528
    Number of pages8
    JournalLab on a Chip
    Volume9
    Issue number4
    DOIs
    Publication statusPublished - 2009

    Keywords

    • PULMONARY DRUG-DELIVERY
    • FORCE OPTICAL TRAP
    • THERAPEUTIC EFFECTIVENESS
    • MEDICATIONS
    • SYSTEMS
    • SIZE

    Cite this

    Butler, Jason R. ; Wills, Jon B. ; Mitchem, Laura ; Burnham, Daniel R. ; McGloin, David ; Reid, Jonathan P. / Spectroscopic characterisation and manipulation of arrays of sub-picolitre aerosol droplets. In: Lab on a Chip. 2009 ; Vol. 9, No. 4. pp. 521-528.
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    abstract = "Arrays of optically tweezed aerosol droplets, each of sub-picolitre volume, are manipulated by holographic optical tweezers and characterised by cavity enhanced Raman spectroscopy. A spatial light modulator is employed to generate arrays of optical traps from a single laser beam and to control the array dimensions and relative trap positions. Comparative hygroscopicity measurements are performed concurrently on five trapped droplets by monitoring the evolving size of each droplet. This is extended to the controlled coalescence of an array of droplets accompanied by spectroscopic measurements. These data represent the first ever simultaneous measurements of the evolving composition and size of an array of aerosol droplets. We consider the possibility of using aerosol arrays as a platform for studying chemical reactions in sub-picolitre volumes, exploiting the versatility of aerosol arrays for performing optical digital microfluidic operations accompanied by micro-total analysis.",
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    Spectroscopic characterisation and manipulation of arrays of sub-picolitre aerosol droplets. / Butler, Jason R.; Wills, Jon B.; Mitchem, Laura; Burnham, Daniel R.; McGloin, David; Reid, Jonathan P.

    In: Lab on a Chip, Vol. 9, No. 4, 2009, p. 521-528.

    Research output: Contribution to journalArticle

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    T1 - Spectroscopic characterisation and manipulation of arrays of sub-picolitre aerosol droplets

    AU - Butler, Jason R.

    AU - Wills, Jon B.

    AU - Mitchem, Laura

    AU - Burnham, Daniel R.

    AU - McGloin, David

    AU - Reid, Jonathan P.

    PY - 2009

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    AB - Arrays of optically tweezed aerosol droplets, each of sub-picolitre volume, are manipulated by holographic optical tweezers and characterised by cavity enhanced Raman spectroscopy. A spatial light modulator is employed to generate arrays of optical traps from a single laser beam and to control the array dimensions and relative trap positions. Comparative hygroscopicity measurements are performed concurrently on five trapped droplets by monitoring the evolving size of each droplet. This is extended to the controlled coalescence of an array of droplets accompanied by spectroscopic measurements. These data represent the first ever simultaneous measurements of the evolving composition and size of an array of aerosol droplets. We consider the possibility of using aerosol arrays as a platform for studying chemical reactions in sub-picolitre volumes, exploiting the versatility of aerosol arrays for performing optical digital microfluidic operations accompanied by micro-total analysis.

    KW - PULMONARY DRUG-DELIVERY

    KW - FORCE OPTICAL TRAP

    KW - THERAPEUTIC EFFECTIVENESS

    KW - MEDICATIONS

    KW - SYSTEMS

    KW - SIZE

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