Synthetic Neoglycoconjugates of Cell-Surface Phosphoglycans of Leishmania as Potential Anti-parasite Carbohydrate Vaccines

A. V. Nikolaev, O. V. Sizova

    Research output: Contribution to journalReview article

    5 Citations (Scopus)

    Abstract

    Leishmania are a genus of sandfly-transmitted protozoan parasites that cause a spectrum of debilitating and often fatal diseases in humans throughout the tropics and subtropics. During the parasite life cycle, Leishmania survive and proliferate in highly hostile environments. Their survival strategies involve the formation of an elaborate and dense cell-surface glycocalyx composed of diverse stage-specific glycoconjugates that form a protective barrier. Phosphoglycans constitute the variable structural and functional domain of major cell-surface lipophosphoglycan and secreted proteophosphoglycans. In this paper, we discuss structural aspects of various phosphoglycans from Leishmania with the major emphasis on the chemical preparation of neoglycoconjugates (neoglycoproteins and neoglycolipids) based on Leishmania lipophosphoglycan structures as well as the immunological evaluation for some of them as potential anti-leishmaniasis vaccines.

    Original languageEnglish
    Pages (from-to)761-773
    Number of pages13
    JournalBiochemistry-Moscow
    Volume76
    Issue number7
    DOIs
    Publication statusPublished - Jul 2011

    Keywords

    • Leishmania
    • lipophosphoglycan
    • carbohydrates
    • neoglycoconjugates
    • glycoconjugate vaccines
    • chemical synthesis
    • DONOVANI ANTIGENIC LIPOPHOSPHOGLYCAN
    • CHEMICAL-SYNTHESIS
    • CUTANEOUS LEISHMANIASIS
    • T-CELL
    • STRUCTURAL-CHARACTERIZATION
    • LIPOPEPTIDE CONJUGATE
    • MENINGOCOCCAL DISEASE
    • PARASITIC PROTOZOA
    • PHOSPHONO ANALOGS
    • IMMUNE-RESPONSE

    Cite this

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    title = "Synthetic Neoglycoconjugates of Cell-Surface Phosphoglycans of Leishmania as Potential Anti-parasite Carbohydrate Vaccines",
    abstract = "Leishmania are a genus of sandfly-transmitted protozoan parasites that cause a spectrum of debilitating and often fatal diseases in humans throughout the tropics and subtropics. During the parasite life cycle, Leishmania survive and proliferate in highly hostile environments. Their survival strategies involve the formation of an elaborate and dense cell-surface glycocalyx composed of diverse stage-specific glycoconjugates that form a protective barrier. Phosphoglycans constitute the variable structural and functional domain of major cell-surface lipophosphoglycan and secreted proteophosphoglycans. In this paper, we discuss structural aspects of various phosphoglycans from Leishmania with the major emphasis on the chemical preparation of neoglycoconjugates (neoglycoproteins and neoglycolipids) based on Leishmania lipophosphoglycan structures as well as the immunological evaluation for some of them as potential anti-leishmaniasis vaccines.",
    keywords = "Leishmania, lipophosphoglycan, carbohydrates, neoglycoconjugates, glycoconjugate vaccines, chemical synthesis, DONOVANI ANTIGENIC LIPOPHOSPHOGLYCAN, CHEMICAL-SYNTHESIS, CUTANEOUS LEISHMANIASIS, T-CELL, STRUCTURAL-CHARACTERIZATION, LIPOPEPTIDE CONJUGATE, MENINGOCOCCAL DISEASE, PARASITIC PROTOZOA, PHOSPHONO ANALOGS, IMMUNE-RESPONSE",
    author = "Nikolaev, {A. V.} and Sizova, {O. V.}",
    year = "2011",
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    doi = "10.1134/S0006297911070066",
    language = "English",
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    pages = "761--773",
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    Synthetic Neoglycoconjugates of Cell-Surface Phosphoglycans of Leishmania as Potential Anti-parasite Carbohydrate Vaccines. / Nikolaev, A. V.; Sizova, O. V.

    In: Biochemistry-Moscow, Vol. 76, No. 7, 07.2011, p. 761-773.

    Research output: Contribution to journalReview article

    TY - JOUR

    T1 - Synthetic Neoglycoconjugates of Cell-Surface Phosphoglycans of Leishmania as Potential Anti-parasite Carbohydrate Vaccines

    AU - Nikolaev, A. V.

    AU - Sizova, O. V.

    PY - 2011/7

    Y1 - 2011/7

    N2 - Leishmania are a genus of sandfly-transmitted protozoan parasites that cause a spectrum of debilitating and often fatal diseases in humans throughout the tropics and subtropics. During the parasite life cycle, Leishmania survive and proliferate in highly hostile environments. Their survival strategies involve the formation of an elaborate and dense cell-surface glycocalyx composed of diverse stage-specific glycoconjugates that form a protective barrier. Phosphoglycans constitute the variable structural and functional domain of major cell-surface lipophosphoglycan and secreted proteophosphoglycans. In this paper, we discuss structural aspects of various phosphoglycans from Leishmania with the major emphasis on the chemical preparation of neoglycoconjugates (neoglycoproteins and neoglycolipids) based on Leishmania lipophosphoglycan structures as well as the immunological evaluation for some of them as potential anti-leishmaniasis vaccines.

    AB - Leishmania are a genus of sandfly-transmitted protozoan parasites that cause a spectrum of debilitating and often fatal diseases in humans throughout the tropics and subtropics. During the parasite life cycle, Leishmania survive and proliferate in highly hostile environments. Their survival strategies involve the formation of an elaborate and dense cell-surface glycocalyx composed of diverse stage-specific glycoconjugates that form a protective barrier. Phosphoglycans constitute the variable structural and functional domain of major cell-surface lipophosphoglycan and secreted proteophosphoglycans. In this paper, we discuss structural aspects of various phosphoglycans from Leishmania with the major emphasis on the chemical preparation of neoglycoconjugates (neoglycoproteins and neoglycolipids) based on Leishmania lipophosphoglycan structures as well as the immunological evaluation for some of them as potential anti-leishmaniasis vaccines.

    KW - Leishmania

    KW - lipophosphoglycan

    KW - carbohydrates

    KW - neoglycoconjugates

    KW - glycoconjugate vaccines

    KW - chemical synthesis

    KW - DONOVANI ANTIGENIC LIPOPHOSPHOGLYCAN

    KW - CHEMICAL-SYNTHESIS

    KW - CUTANEOUS LEISHMANIASIS

    KW - T-CELL

    KW - STRUCTURAL-CHARACTERIZATION

    KW - LIPOPEPTIDE CONJUGATE

    KW - MENINGOCOCCAL DISEASE

    KW - PARASITIC PROTOZOA

    KW - PHOSPHONO ANALOGS

    KW - IMMUNE-RESPONSE

    U2 - 10.1134/S0006297911070066

    DO - 10.1134/S0006297911070066

    M3 - Review article

    VL - 76

    SP - 761

    EP - 773

    JO - Biochemistry-Moscow

    JF - Biochemistry-Moscow

    SN - 0006-2979

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    ER -