The characterisation and determinants of quality of life in ANCA associated vasculitis

Neil Basu (Lead / Corresponding author), Andrew McClean, Lorraine Harper, Esther Nicole Amft, Neeraj Dhaun, Raashid A. Luqmani, Mark A. Little, David R.W. Jayne, Oliver Flossmann, John McLaren, Vinod Kumar, Lars P. Erwig, David M. Reid, Gareth T. Jones, Gary J. Macfarlane

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    21 Citations (Scopus)

    Abstract

    Objectives To contextualise and identify the determinants of poor health related quality of life (QOL) among patients with antineutrophil cytoplasm antibody (ANCA) associated vasculitis (AAV)
    Methods A multicentre AAV case-control study was conducted using two matched groups of population and chronic disease controls. Measures of physical and mental QOL as well as putative bio-psychosocial determinants of QOL impairment were collected. Concurrently, putative clinical QOL determinants were recorded. Conditional logistic regression analyses characterised group differences while multivariable logistic regression identified within-case QOL associations which were further quantified using population attributable risks (PAR)
    Results Cases (n=410) experienced similar QOL to chronic disease controls (n=318) ( physical QOL: OR 0.7, 95% CI 0.4 to 1.1; mental QOL: OR 1.1, 95% CI 0.8 to 1.6). However, they were substantially more likely to report poor QOL compared to general population controls (n=470) ( physical QOL: OR 7.0, 95% CI 4.4 to 11.1; mental QOL: OR 2.5, 95% CI 1.7 to 3.6). A few clinical, but many more bio-psychosocial factors were independently associated with poor QOL. In population terms, fatigue was found to be of principal importance (physical QOL: PAR 24.6%; mental QOL: PAR 47.4%)
    Conclusions AAV patients experienced significant QOL impairment compared to the general population, but similar to those with other chronic diseases whose considerable needs are already recognised. Potentially modifiable clinical determinants have been identified; however bio-psychosocial interventions are likely to provide the greater QOL gains in this patient population.
    Original languageEnglish
    Pages (from-to)207-211
    Number of pages5
    JournalAnnals of the Rheumatic Diseases
    Volume73
    Issue number1
    DOIs
    Publication statusPublished - Jan 2014

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    Vasculitis
    Disease control
    Antineutrophil Cytoplasmic Antibodies
    Cytoplasm
    Quality of Life
    Logistics
    Antibodies
    Health
    Fatigue of materials
    Population
    Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
    Chronic Disease
    Logistic Models
    Population Control
    Fatigue
    Case-Control Studies

    Cite this

    Basu, N., McClean, A., Harper, L., Amft, E. N., Dhaun, N., Luqmani, R. A., ... Macfarlane, G. J. (2014). The characterisation and determinants of quality of life in ANCA associated vasculitis. Annals of the Rheumatic Diseases, 73(1), 207-211. https://doi.org/10.1136/annrheumdis-2012-202750
    Basu, Neil ; McClean, Andrew ; Harper, Lorraine ; Amft, Esther Nicole ; Dhaun, Neeraj ; Luqmani, Raashid A. ; Little, Mark A. ; Jayne, David R.W. ; Flossmann, Oliver ; McLaren, John ; Kumar, Vinod ; Erwig, Lars P. ; Reid, David M. ; Jones, Gareth T. ; Macfarlane, Gary J. / The characterisation and determinants of quality of life in ANCA associated vasculitis. In: Annals of the Rheumatic Diseases. 2014 ; Vol. 73, No. 1. pp. 207-211.
    @article{e8589eb9c925498fab12fe6f48c7dfb5,
    title = "The characterisation and determinants of quality of life in ANCA associated vasculitis",
    abstract = "Objectives To contextualise and identify the determinants of poor health related quality of life (QOL) among patients with antineutrophil cytoplasm antibody (ANCA) associated vasculitis (AAV)Methods A multicentre AAV case-control study was conducted using two matched groups of population and chronic disease controls. Measures of physical and mental QOL as well as putative bio-psychosocial determinants of QOL impairment were collected. Concurrently, putative clinical QOL determinants were recorded. Conditional logistic regression analyses characterised group differences while multivariable logistic regression identified within-case QOL associations which were further quantified using population attributable risks (PAR)Results Cases (n=410) experienced similar QOL to chronic disease controls (n=318) ( physical QOL: OR 0.7, 95{\%} CI 0.4 to 1.1; mental QOL: OR 1.1, 95{\%} CI 0.8 to 1.6). However, they were substantially more likely to report poor QOL compared to general population controls (n=470) ( physical QOL: OR 7.0, 95{\%} CI 4.4 to 11.1; mental QOL: OR 2.5, 95{\%} CI 1.7 to 3.6). A few clinical, but many more bio-psychosocial factors were independently associated with poor QOL. In population terms, fatigue was found to be of principal importance (physical QOL: PAR 24.6{\%}; mental QOL: PAR 47.4{\%})Conclusions AAV patients experienced significant QOL impairment compared to the general population, but similar to those with other chronic diseases whose considerable needs are already recognised. Potentially modifiable clinical determinants have been identified; however bio-psychosocial interventions are likely to provide the greater QOL gains in this patient population.",
    author = "Neil Basu and Andrew McClean and Lorraine Harper and Amft, {Esther Nicole} and Neeraj Dhaun and Luqmani, {Raashid A.} and Little, {Mark A.} and Jayne, {David R.W.} and Oliver Flossmann and John McLaren and Vinod Kumar and Erwig, {Lars P.} and Reid, {David M.} and Jones, {Gareth T.} and Macfarlane, {Gary J.}",
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    Basu, N, McClean, A, Harper, L, Amft, EN, Dhaun, N, Luqmani, RA, Little, MA, Jayne, DRW, Flossmann, O, McLaren, J, Kumar, V, Erwig, LP, Reid, DM, Jones, GT & Macfarlane, GJ 2014, 'The characterisation and determinants of quality of life in ANCA associated vasculitis', Annals of the Rheumatic Diseases, vol. 73, no. 1, pp. 207-211. https://doi.org/10.1136/annrheumdis-2012-202750

    The characterisation and determinants of quality of life in ANCA associated vasculitis. / Basu, Neil (Lead / Corresponding author); McClean, Andrew; Harper, Lorraine; Amft, Esther Nicole; Dhaun, Neeraj; Luqmani, Raashid A.; Little, Mark A.; Jayne, David R.W.; Flossmann, Oliver; McLaren, John; Kumar, Vinod; Erwig, Lars P.; Reid, David M.; Jones, Gareth T.; Macfarlane, Gary J.

    In: Annals of the Rheumatic Diseases, Vol. 73, No. 1, 01.2014, p. 207-211.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - The characterisation and determinants of quality of life in ANCA associated vasculitis

    AU - Basu, Neil

    AU - McClean, Andrew

    AU - Harper, Lorraine

    AU - Amft, Esther Nicole

    AU - Dhaun, Neeraj

    AU - Luqmani, Raashid A.

    AU - Little, Mark A.

    AU - Jayne, David R.W.

    AU - Flossmann, Oliver

    AU - McLaren, John

    AU - Kumar, Vinod

    AU - Erwig, Lars P.

    AU - Reid, David M.

    AU - Jones, Gareth T.

    AU - Macfarlane, Gary J.

    PY - 2014/1

    Y1 - 2014/1

    N2 - Objectives To contextualise and identify the determinants of poor health related quality of life (QOL) among patients with antineutrophil cytoplasm antibody (ANCA) associated vasculitis (AAV)Methods A multicentre AAV case-control study was conducted using two matched groups of population and chronic disease controls. Measures of physical and mental QOL as well as putative bio-psychosocial determinants of QOL impairment were collected. Concurrently, putative clinical QOL determinants were recorded. Conditional logistic regression analyses characterised group differences while multivariable logistic regression identified within-case QOL associations which were further quantified using population attributable risks (PAR)Results Cases (n=410) experienced similar QOL to chronic disease controls (n=318) ( physical QOL: OR 0.7, 95% CI 0.4 to 1.1; mental QOL: OR 1.1, 95% CI 0.8 to 1.6). However, they were substantially more likely to report poor QOL compared to general population controls (n=470) ( physical QOL: OR 7.0, 95% CI 4.4 to 11.1; mental QOL: OR 2.5, 95% CI 1.7 to 3.6). A few clinical, but many more bio-psychosocial factors were independently associated with poor QOL. In population terms, fatigue was found to be of principal importance (physical QOL: PAR 24.6%; mental QOL: PAR 47.4%)Conclusions AAV patients experienced significant QOL impairment compared to the general population, but similar to those with other chronic diseases whose considerable needs are already recognised. Potentially modifiable clinical determinants have been identified; however bio-psychosocial interventions are likely to provide the greater QOL gains in this patient population.

    AB - Objectives To contextualise and identify the determinants of poor health related quality of life (QOL) among patients with antineutrophil cytoplasm antibody (ANCA) associated vasculitis (AAV)Methods A multicentre AAV case-control study was conducted using two matched groups of population and chronic disease controls. Measures of physical and mental QOL as well as putative bio-psychosocial determinants of QOL impairment were collected. Concurrently, putative clinical QOL determinants were recorded. Conditional logistic regression analyses characterised group differences while multivariable logistic regression identified within-case QOL associations which were further quantified using population attributable risks (PAR)Results Cases (n=410) experienced similar QOL to chronic disease controls (n=318) ( physical QOL: OR 0.7, 95% CI 0.4 to 1.1; mental QOL: OR 1.1, 95% CI 0.8 to 1.6). However, they were substantially more likely to report poor QOL compared to general population controls (n=470) ( physical QOL: OR 7.0, 95% CI 4.4 to 11.1; mental QOL: OR 2.5, 95% CI 1.7 to 3.6). A few clinical, but many more bio-psychosocial factors were independently associated with poor QOL. In population terms, fatigue was found to be of principal importance (physical QOL: PAR 24.6%; mental QOL: PAR 47.4%)Conclusions AAV patients experienced significant QOL impairment compared to the general population, but similar to those with other chronic diseases whose considerable needs are already recognised. Potentially modifiable clinical determinants have been identified; however bio-psychosocial interventions are likely to provide the greater QOL gains in this patient population.

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