The colorectal adenoma-carcinoma sequence

A. Leslie, F. A. Carey, N. R. Pratt, R. J. C. Steele

    Research output: Contribution to journalArticle

    352 Citations (Scopus)

    Abstract

    It is widely accepted that the adenoma-carcinoma sequence represents the process by which most, if not all, colorectal cancers arise. The evidence supporting this hypothesis has increased rapidly in recent years and the purpose of this article is to review this evidence critically and highlight its clinical significance.
    Original languageEnglish
    Pages (from-to)845-60
    Number of pages16
    JournalBritish Journal of Surgery
    Volume89
    Issue number7
    DOIs
    Publication statusPublished - Jul 2002

    Fingerprint

    Adenoma
    Colorectal Neoplasms
    Carcinoma

    Keywords

    • Adenoma
    • Adenomatous Polyposis Coli Protein
    • Base Pair Mismatch
    • Carcinoma
    • Cell Transformation, Neoplastic
    • Colorectal Neoplasms
    • DNA Methylation
    • DNA Repair
    • Gene Deletion
    • Gene Expression
    • Genes, p53
    • Genes, ras
    • Humans
    • Karyotyping
    • Microsatellite Repeats
    • Mutation

    Cite this

    Leslie, A. ; Carey, F. A. ; Pratt, N. R. ; Steele, R. J. C. / The colorectal adenoma-carcinoma sequence. In: British Journal of Surgery. 2002 ; Vol. 89, No. 7. pp. 845-60.
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    The colorectal adenoma-carcinoma sequence. / Leslie, A.; Carey, F. A.; Pratt, N. R.; Steele, R. J. C.

    In: British Journal of Surgery, Vol. 89, No. 7, 07.2002, p. 845-60.

    Research output: Contribution to journalArticle

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    AU - Leslie, A.

    AU - Carey, F. A.

    AU - Pratt, N. R.

    AU - Steele, R. J. C.

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    KW - Carcinoma

    KW - Cell Transformation, Neoplastic

    KW - Colorectal Neoplasms

    KW - DNA Methylation

    KW - DNA Repair

    KW - Gene Deletion

    KW - Gene Expression

    KW - Genes, p53

    KW - Genes, ras

    KW - Humans

    KW - Karyotyping

    KW - Microsatellite Repeats

    KW - Mutation

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