THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview

Stephen P. H. Alexander, Eamonn Kelly, Neil V. Marrion, John A. Peters, Elena Faccenda, Simon D. Harding, Adam J. Pawson, Joanna L. Sharman, Christopher Southan, O. Peter Buneman, John A. Cidlowski, Arthur Christopoulos, Anthony P. Davenport, Doriano Fabbro, Michael Spedding, Jörg Striessnig, Jamie A. Davies, CGTP Collaborators

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Abstract

The Concise Guide to PHARMACOLOGY 2017/18 is the third in this series of biennial publications. This version provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13882/full. In addition to this overview, in which are identified 'Other protein targets' which fall outside of the subsequent categorisation, there are eight areas of focus: G protein-coupled receptors, ligand-gated ion channels, voltage-gated ion channels, other ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2017, and supersedes data presented in the 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature Committee of the Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

Original languageEnglish
Pages (from-to)S1-S16
Number of pages16
JournalBritish Journal of Pharmacology
Volume174
Issue numberSuppl. 1
Early online date21 Oct 2017
DOIs
Publication statusPublished - Dec 2017

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Terminology
Pharmacology
Ion Channels
Pharmaceutical Preparations
Ligands
Ligand-Gated Ion Channels
Knowledge Bases
Clinical Pharmacology
Cytoplasmic and Nuclear Receptors
G-Protein-Coupled Receptors
Publications
Reading
Databases
Enzymes
Proteins

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Alexander, S. P. H., Kelly, E., Marrion, N. V., Peters, J. A., Faccenda, E., Harding, S. D., ... CGTP Collaborators (2017). THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview. British Journal of Pharmacology, 174 (Suppl. 1), S1-S16. https://doi.org/10.1111/bph.13882
Alexander, Stephen P. H. ; Kelly, Eamonn ; Marrion, Neil V. ; Peters, John A. ; Faccenda, Elena ; Harding, Simon D. ; Pawson, Adam J. ; Sharman, Joanna L. ; Southan, Christopher ; Buneman, O. Peter ; Cidlowski, John A. ; Christopoulos, Arthur ; Davenport, Anthony P. ; Fabbro, Doriano ; Spedding, Michael ; Striessnig, Jörg ; Davies, Jamie A. ; CGTP Collaborators. / THE CONCISE GUIDE TO PHARMACOLOGY 2017/18 : Overview. In: British Journal of Pharmacology. 2017 ; Vol. 174 , No. Suppl. 1. pp. S1-S16.
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abstract = "The Concise Guide to PHARMACOLOGY 2017/18 is the third in this series of biennial publications. This version provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13882/full. In addition to this overview, in which are identified 'Other protein targets' which fall outside of the subsequent categorisation, there are eight areas of focus: G protein-coupled receptors, ligand-gated ion channels, voltage-gated ion channels, other ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2017, and supersedes data presented in the 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature Committee of the Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.",
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Alexander, SPH, Kelly, E, Marrion, NV, Peters, JA, Faccenda, E, Harding, SD, Pawson, AJ, Sharman, JL, Southan, C, Buneman, OP, Cidlowski, JA, Christopoulos, A, Davenport, AP, Fabbro, D, Spedding, M, Striessnig, J, Davies, JA & CGTP Collaborators 2017, 'THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview', British Journal of Pharmacology, vol. 174 , no. Suppl. 1, pp. S1-S16. https://doi.org/10.1111/bph.13882

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18 : Overview. / Alexander, Stephen P. H.; Kelly, Eamonn; Marrion, Neil V.; Peters, John A.; Faccenda, Elena; Harding, Simon D.; Pawson, Adam J.; Sharman, Joanna L.; Southan, Christopher; Buneman, O. Peter; Cidlowski, John A.; Christopoulos, Arthur; Davenport, Anthony P.; Fabbro, Doriano; Spedding, Michael; Striessnig, Jörg; Davies, Jamie A.; CGTP Collaborators.

In: British Journal of Pharmacology, Vol. 174 , No. Suppl. 1, 12.2017, p. S1-S16.

Research output: Contribution to journalArticle

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AU - Alexander, Stephen P. H.

AU - Kelly, Eamonn

AU - Marrion, Neil V.

AU - Peters, John A.

AU - Faccenda, Elena

AU - Harding, Simon D.

AU - Pawson, Adam J.

AU - Sharman, Joanna L.

AU - Southan, Christopher

AU - Buneman, O. Peter

AU - Cidlowski, John A.

AU - Christopoulos, Arthur

AU - Davenport, Anthony P.

AU - Fabbro, Doriano

AU - Spedding, Michael

AU - Striessnig, Jörg

AU - Davies, Jamie A.

AU - CGTP Collaborators

N1 - We are extremely grateful to the British Pharmacological Society and the International Union of Basic and Clinical Pharmacology, for financial suppo rt of the website and for advice from the NC-IUPHAR subcommittees. We thank the University of Edinburgh, who host the www.guidetopharmacology.org website. Previously, the International Union of Basic and Clinical Pharmacology and the Wellcome Trust (099156/Z/12/Z]) also supported the initiation and expansion of the database.

PY - 2017/12

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N2 - The Concise Guide to PHARMACOLOGY 2017/18 is the third in this series of biennial publications. This version provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13882/full. In addition to this overview, in which are identified 'Other protein targets' which fall outside of the subsequent categorisation, there are eight areas of focus: G protein-coupled receptors, ligand-gated ion channels, voltage-gated ion channels, other ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2017, and supersedes data presented in the 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature Committee of the Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

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Alexander SPH, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD et al. THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview. British Journal of Pharmacology. 2017 Dec;174 (Suppl. 1):S1-S16. https://doi.org/10.1111/bph.13882