The correlation between reading and mathematics ability at age twelve has a substantial genetic component

Oliver S. P. Davis (Lead / Corresponding author), Gavin Band, Matti Pirinen, Claire M. A. Haworth, Emma L. Meaburn, Yulia Kovas, Nicole Harlaar, Sophia J. Docherty, Ken B. Hanscombe, Maciej Trzaskowski, Charles J. C. Curtis, Amy Strange, Colin Freeman, Céline Bellenguez, Zhan Su, Richard Pearson, Damjan Vukcevic, Cordelia Langford, Panos Deloukas, Sarah HuntEmma Gray, Serge Dronov, Simon C. Potter, Avazeh Tashakkori-Ghanbaria, Sarah Edkins, Suzannah J. Bumpstead, Jenefer M. Blackwell, Elvira Bramon, Matthew A. Brown, Juan P. Casas, Aiden Corvin, Audrey Duncanson, Janusz A Z Jankowski, Hugh S. Markus, Christopher G. Mathew, Colin N. A. Palmer, Anna Rautanen, Stephen J. Sawcer, Richard C. Trembath, Ananth C. Viswanathan, Nicholas W. Wood, Ines Barroso, Leena Peltonen, Philip S. Dale, Stephen A. Petrill, Leonard S. Schalkwyk, Ian W Craig, Cathryn M. Lewis, Thomas S. Price, Peter Donnelly, Wellcome Trust Case Control Consortium

    Research output: Contribution to journalArticle

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    Abstract

    Dissecting how genetic and environmental influences impact on learning is helpful for maximizing numeracy and literacy. Here we show, using twin and genome-wide analysis, that there is a substantial genetic component to children's ability in reading and mathematics, and estimate that around one half of the observed correlation in these traits is due to shared genetic effects (so-called Generalist Genes). Thus, our results highlight the potential role of the learning environment in contributing to differences in a child's cognitive abilities at age twelve.
    Original languageEnglish
    Article number4204
    Number of pages6
    JournalNature Communications
    Volume5
    DOIs
    Publication statusPublished - 8 Jul 2014

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    Mathematics
    mathematics
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    Genes
    Learning
    learning
    Environmental impact
    genome
    Genome
    genes
    estimates
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    Cite this

    Davis, O. S. P., Band, G., Pirinen, M., Haworth, C. M. A., Meaburn, E. L., Kovas, Y., ... Wellcome Trust Case Control Consortium (2014). The correlation between reading and mathematics ability at age twelve has a substantial genetic component. Nature Communications, 5, [4204]. https://doi.org/10.1038/ncomms5204
    Davis, Oliver S. P. ; Band, Gavin ; Pirinen, Matti ; Haworth, Claire M. A. ; Meaburn, Emma L. ; Kovas, Yulia ; Harlaar, Nicole ; Docherty, Sophia J. ; Hanscombe, Ken B. ; Trzaskowski, Maciej ; Curtis, Charles J. C. ; Strange, Amy ; Freeman, Colin ; Bellenguez, Céline ; Su, Zhan ; Pearson, Richard ; Vukcevic, Damjan ; Langford, Cordelia ; Deloukas, Panos ; Hunt, Sarah ; Gray, Emma ; Dronov, Serge ; Potter, Simon C. ; Tashakkori-Ghanbaria, Avazeh ; Edkins, Sarah ; Bumpstead, Suzannah J. ; Blackwell, Jenefer M. ; Bramon, Elvira ; Brown, Matthew A. ; Casas, Juan P. ; Corvin, Aiden ; Duncanson, Audrey ; Jankowski, Janusz A Z ; Markus, Hugh S. ; Mathew, Christopher G. ; Palmer, Colin N. A. ; Rautanen, Anna ; Sawcer, Stephen J. ; Trembath, Richard C. ; Viswanathan, Ananth C. ; Wood, Nicholas W. ; Barroso, Ines ; Peltonen, Leena ; Dale, Philip S. ; Petrill, Stephen A. ; Schalkwyk, Leonard S. ; Craig, Ian W ; Lewis, Cathryn M. ; Price, Thomas S. ; Donnelly, Peter ; Wellcome Trust Case Control Consortium. / The correlation between reading and mathematics ability at age twelve has a substantial genetic component. In: Nature Communications. 2014 ; Vol. 5.
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    title = "The correlation between reading and mathematics ability at age twelve has a substantial genetic component",
    abstract = "Dissecting how genetic and environmental influences impact on learning is helpful for maximizing numeracy and literacy. Here we show, using twin and genome-wide analysis, that there is a substantial genetic component to children's ability in reading and mathematics, and estimate that around one half of the observed correlation in these traits is due to shared genetic effects (so-called Generalist Genes). Thus, our results highlight the potential role of the learning environment in contributing to differences in a child's cognitive abilities at age twelve.",
    author = "Davis, {Oliver S. P.} and Gavin Band and Matti Pirinen and Haworth, {Claire M. A.} and Meaburn, {Emma L.} and Yulia Kovas and Nicole Harlaar and Docherty, {Sophia J.} and Hanscombe, {Ken B.} and Maciej Trzaskowski and Curtis, {Charles J. C.} and Amy Strange and Colin Freeman and C{\'e}line Bellenguez and Zhan Su and Richard Pearson and Damjan Vukcevic and Cordelia Langford and Panos Deloukas and Sarah Hunt and Emma Gray and Serge Dronov and Potter, {Simon C.} and Avazeh Tashakkori-Ghanbaria and Sarah Edkins and Bumpstead, {Suzannah J.} and Blackwell, {Jenefer M.} and Elvira Bramon and Brown, {Matthew A.} and Casas, {Juan P.} and Aiden Corvin and Audrey Duncanson and Jankowski, {Janusz A Z} and Markus, {Hugh S.} and Mathew, {Christopher G.} and Palmer, {Colin N. A.} and Anna Rautanen and Sawcer, {Stephen J.} and Trembath, {Richard C.} and Viswanathan, {Ananth C.} and Wood, {Nicholas W.} and Ines Barroso and Leena Peltonen and Dale, {Philip S.} and Petrill, {Stephen A.} and Schalkwyk, {Leonard S.} and Craig, {Ian W} and Lewis, {Cathryn M.} and Price, {Thomas S.} and Peter Donnelly and {Wellcome Trust Case Control Consortium}",
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    Davis, OSP, Band, G, Pirinen, M, Haworth, CMA, Meaburn, EL, Kovas, Y, Harlaar, N, Docherty, SJ, Hanscombe, KB, Trzaskowski, M, Curtis, CJC, Strange, A, Freeman, C, Bellenguez, C, Su, Z, Pearson, R, Vukcevic, D, Langford, C, Deloukas, P, Hunt, S, Gray, E, Dronov, S, Potter, SC, Tashakkori-Ghanbaria, A, Edkins, S, Bumpstead, SJ, Blackwell, JM, Bramon, E, Brown, MA, Casas, JP, Corvin, A, Duncanson, A, Jankowski, JAZ, Markus, HS, Mathew, CG, Palmer, CNA, Rautanen, A, Sawcer, SJ, Trembath, RC, Viswanathan, AC, Wood, NW, Barroso, I, Peltonen, L, Dale, PS, Petrill, SA, Schalkwyk, LS, Craig, IW, Lewis, CM, Price, TS, Donnelly, P & Wellcome Trust Case Control Consortium 2014, 'The correlation between reading and mathematics ability at age twelve has a substantial genetic component', Nature Communications, vol. 5, 4204. https://doi.org/10.1038/ncomms5204

    The correlation between reading and mathematics ability at age twelve has a substantial genetic component. / Davis, Oliver S. P. (Lead / Corresponding author); Band, Gavin; Pirinen, Matti; Haworth, Claire M. A.; Meaburn, Emma L.; Kovas, Yulia; Harlaar, Nicole; Docherty, Sophia J.; Hanscombe, Ken B.; Trzaskowski, Maciej; Curtis, Charles J. C.; Strange, Amy; Freeman, Colin; Bellenguez, Céline; Su, Zhan; Pearson, Richard; Vukcevic, Damjan; Langford, Cordelia; Deloukas, Panos; Hunt, Sarah; Gray, Emma; Dronov, Serge; Potter, Simon C.; Tashakkori-Ghanbaria, Avazeh; Edkins, Sarah; Bumpstead, Suzannah J.; Blackwell, Jenefer M.; Bramon, Elvira; Brown, Matthew A.; Casas, Juan P.; Corvin, Aiden; Duncanson, Audrey; Jankowski, Janusz A Z; Markus, Hugh S.; Mathew, Christopher G.; Palmer, Colin N. A.; Rautanen, Anna; Sawcer, Stephen J.; Trembath, Richard C.; Viswanathan, Ananth C.; Wood, Nicholas W.; Barroso, Ines; Peltonen, Leena; Dale, Philip S.; Petrill, Stephen A.; Schalkwyk, Leonard S.; Craig, Ian W; Lewis, Cathryn M.; Price, Thomas S. ; Donnelly, Peter; Wellcome Trust Case Control Consortium.

    In: Nature Communications, Vol. 5, 4204, 08.07.2014.

    Research output: Contribution to journalArticle

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    AU - Pirinen, Matti

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    AU - Meaburn, Emma L.

    AU - Kovas, Yulia

    AU - Harlaar, Nicole

    AU - Docherty, Sophia J.

    AU - Hanscombe, Ken B.

    AU - Trzaskowski, Maciej

    AU - Curtis, Charles J. C.

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    AU - Freeman, Colin

    AU - Bellenguez, Céline

    AU - Su, Zhan

    AU - Pearson, Richard

    AU - Vukcevic, Damjan

    AU - Langford, Cordelia

    AU - Deloukas, Panos

    AU - Hunt, Sarah

    AU - Gray, Emma

    AU - Dronov, Serge

    AU - Potter, Simon C.

    AU - Tashakkori-Ghanbaria, Avazeh

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    AU - Bumpstead, Suzannah J.

    AU - Blackwell, Jenefer M.

    AU - Bramon, Elvira

    AU - Brown, Matthew A.

    AU - Casas, Juan P.

    AU - Corvin, Aiden

    AU - Duncanson, Audrey

    AU - Jankowski, Janusz A Z

    AU - Markus, Hugh S.

    AU - Mathew, Christopher G.

    AU - Palmer, Colin N. A.

    AU - Rautanen, Anna

    AU - Sawcer, Stephen J.

    AU - Trembath, Richard C.

    AU - Viswanathan, Ananth C.

    AU - Wood, Nicholas W.

    AU - Barroso, Ines

    AU - Peltonen, Leena

    AU - Dale, Philip S.

    AU - Petrill, Stephen A.

    AU - Schalkwyk, Leonard S.

    AU - Craig, Ian W

    AU - Lewis, Cathryn M.

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    AU - Donnelly, Peter

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    AB - Dissecting how genetic and environmental influences impact on learning is helpful for maximizing numeracy and literacy. Here we show, using twin and genome-wide analysis, that there is a substantial genetic component to children's ability in reading and mathematics, and estimate that around one half of the observed correlation in these traits is due to shared genetic effects (so-called Generalist Genes). Thus, our results highlight the potential role of the learning environment in contributing to differences in a child's cognitive abilities at age twelve.

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