The Development of a Combined Electrical & Mechanical Stimulation Bioreactor to Improve Tissue Engineered Muscle Function

J.B. Vorstius, R.P. Keatch, K. Donnelly, P. S. Maher

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    This paper describes the development of novel bioreactor systems for use in studying the development of tissue engineered muscle constructs. The bioreactor systems combine two environmental stimuli, mechanical loading and electrical pulses which, independently, are known to promote muscle tissue growth, into a single system to investigate whether further functional improvements can be achieved. The bioreactors are reprogrammable to enable different stimulation protocols to be assessed and allow the simultaneous stimulation of up to six tissues in a single system. This allows us to improve experimental throughput and speeds up our understanding of the physiological processes involved in skeletal muscle development.

    Original languageEnglish
    Title of host publicationWorld Congress on Medical Physics and Biomedical Engineering, Vol 25, Pt 10
    EditorsO Dossel, WC Schlegel
    Place of PublicationNew York
    PublisherSpringer
    Pages126-129
    Number of pages4
    ISBN (Print)978-3-642-03899-0
    Publication statusPublished - 2009
    EventWorld Congress on Medical Physics and Biomedical Engineering - Munich, Germany
    Duration: 7 Sep 200912 Sep 2009
    http://conference.vde.com/world-congress-2009/Pages/Home.aspx

    Conference

    ConferenceWorld Congress on Medical Physics and Biomedical Engineering
    CountryGermany
    CityMunich
    Period7/09/0912/09/09
    Internet address

    Keywords

    • bioreactor
    • muscle
    • stimulation
    • electrical
    • mechanical
    • SKELETAL-MUSCLE
    • IN-VITRO
    • EXERCISE
    • MYOSIN
    • RESISTANCE
    • ISOFORMS
    • MASS

    Cite this

    Vorstius, J. B., Keatch, R. P., Donnelly, K., & Maher, P. S. (2009). The Development of a Combined Electrical & Mechanical Stimulation Bioreactor to Improve Tissue Engineered Muscle Function. In O. Dossel, & WC. Schlegel (Eds.), World Congress on Medical Physics and Biomedical Engineering, Vol 25, Pt 10 (pp. 126-129). New York: Springer .
    Vorstius, J.B. ; Keatch, R.P. ; Donnelly, K. ; Maher, P. S. / The Development of a Combined Electrical & Mechanical Stimulation Bioreactor to Improve Tissue Engineered Muscle Function. World Congress on Medical Physics and Biomedical Engineering, Vol 25, Pt 10. editor / O Dossel ; WC Schlegel. New York : Springer , 2009. pp. 126-129
    @inproceedings{1cfe8b4a75f44f228da9873532a25317,
    title = "The Development of a Combined Electrical & Mechanical Stimulation Bioreactor to Improve Tissue Engineered Muscle Function",
    abstract = "This paper describes the development of novel bioreactor systems for use in studying the development of tissue engineered muscle constructs. The bioreactor systems combine two environmental stimuli, mechanical loading and electrical pulses which, independently, are known to promote muscle tissue growth, into a single system to investigate whether further functional improvements can be achieved. The bioreactors are reprogrammable to enable different stimulation protocols to be assessed and allow the simultaneous stimulation of up to six tissues in a single system. This allows us to improve experimental throughput and speeds up our understanding of the physiological processes involved in skeletal muscle development.",
    keywords = "bioreactor, muscle, stimulation, electrical, mechanical, SKELETAL-MUSCLE, IN-VITRO, EXERCISE, MYOSIN, RESISTANCE, ISOFORMS, MASS",
    author = "J.B. Vorstius and R.P. Keatch and K. Donnelly and Maher, {P. S.}",
    year = "2009",
    language = "English",
    isbn = "978-3-642-03899-0",
    pages = "126--129",
    editor = "O Dossel and WC Schlegel",
    booktitle = "World Congress on Medical Physics and Biomedical Engineering, Vol 25, Pt 10",
    publisher = "Springer",

    }

    Vorstius, JB, Keatch, RP, Donnelly, K & Maher, PS 2009, The Development of a Combined Electrical & Mechanical Stimulation Bioreactor to Improve Tissue Engineered Muscle Function. in O Dossel & WC Schlegel (eds), World Congress on Medical Physics and Biomedical Engineering, Vol 25, Pt 10. Springer , New York, pp. 126-129, World Congress on Medical Physics and Biomedical Engineering, Munich, Germany, 7/09/09.

    The Development of a Combined Electrical & Mechanical Stimulation Bioreactor to Improve Tissue Engineered Muscle Function. / Vorstius, J.B.; Keatch, R.P.; Donnelly, K.; Maher, P. S.

    World Congress on Medical Physics and Biomedical Engineering, Vol 25, Pt 10. ed. / O Dossel; WC Schlegel. New York : Springer , 2009. p. 126-129.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    TY - GEN

    T1 - The Development of a Combined Electrical & Mechanical Stimulation Bioreactor to Improve Tissue Engineered Muscle Function

    AU - Vorstius, J.B.

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    AU - Donnelly, K.

    AU - Maher, P. S.

    PY - 2009

    Y1 - 2009

    N2 - This paper describes the development of novel bioreactor systems for use in studying the development of tissue engineered muscle constructs. The bioreactor systems combine two environmental stimuli, mechanical loading and electrical pulses which, independently, are known to promote muscle tissue growth, into a single system to investigate whether further functional improvements can be achieved. The bioreactors are reprogrammable to enable different stimulation protocols to be assessed and allow the simultaneous stimulation of up to six tissues in a single system. This allows us to improve experimental throughput and speeds up our understanding of the physiological processes involved in skeletal muscle development.

    AB - This paper describes the development of novel bioreactor systems for use in studying the development of tissue engineered muscle constructs. The bioreactor systems combine two environmental stimuli, mechanical loading and electrical pulses which, independently, are known to promote muscle tissue growth, into a single system to investigate whether further functional improvements can be achieved. The bioreactors are reprogrammable to enable different stimulation protocols to be assessed and allow the simultaneous stimulation of up to six tissues in a single system. This allows us to improve experimental throughput and speeds up our understanding of the physiological processes involved in skeletal muscle development.

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    KW - muscle

    KW - stimulation

    KW - electrical

    KW - mechanical

    KW - SKELETAL-MUSCLE

    KW - IN-VITRO

    KW - EXERCISE

    KW - MYOSIN

    KW - RESISTANCE

    KW - ISOFORMS

    KW - MASS

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    SN - 978-3-642-03899-0

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    EP - 129

    BT - World Congress on Medical Physics and Biomedical Engineering, Vol 25, Pt 10

    A2 - Dossel, O

    A2 - Schlegel, WC

    PB - Springer

    CY - New York

    ER -

    Vorstius JB, Keatch RP, Donnelly K, Maher PS. The Development of a Combined Electrical & Mechanical Stimulation Bioreactor to Improve Tissue Engineered Muscle Function. In Dossel O, Schlegel WC, editors, World Congress on Medical Physics and Biomedical Engineering, Vol 25, Pt 10. New York: Springer . 2009. p. 126-129