The neuropsychological effects of chronic methylphenidate on drug-naive boys with attention-deficit/hyperactivity disorder

David R. Coghill, Sinead M. Rhodes, Keith Matthews

    Research output: Contribution to journalArticle

    116 Citations (Scopus)

    Abstract

    Background: The reported neuropsychological effects of methylphenidate (MPH) in attention-de ficit/hyperactivity disorder (ADHD) are inconsistent. The assumed relationships between these neuropsychological effects and clinical efficacy have not been substantiated. We therefore investigated the effects of chronic MPH administration on neuropsychological functioning. Methods: We conducted a 12-week, placebo-controlled, double-blinded, randomized, crossover trial (MPH .3 and .6 mg/kg/dose and placebo). Participants were 75 boys aged 7–15 years with ADHD. Neuropsychological performance was assessed with tests taken from the Cambridge Neuropsychological Test Automated Battery (CANTAB) battery and a GoNoGo task. Results: ChronicMPHimproved performance (p<.001) on aspects of theGoNoGotask (p<.02) and on threeCANTABtasks which together contributed to a “recognition memory” component identified through principal components analysis (delayed matching to sample [DMtS], Pattern and spatial recognition). There were no effects on other, high or low “executive demand” tasks (p>.05). GoNoGo performance improvements were the only neuropsychopharmacological changes associated with clinical response. Poor performance on the DMtS task was the sole baseline neuropsychological predictor of clinical response. Conclusions: Chronic MPH predominantly enhanced neuropsychological functioning on “recognition memory” component tasks with modest “executive” demands. Neuropsychological measures offer only modest contributions to the prediction of clinical responses to MPH in ADHD.
    Original languageEnglish
    Pages (from-to)954-962
    Number of pages9
    JournalBiological Psychiatry
    Volume62
    Issue number9
    DOIs
    Publication statusPublished - Nov 2007

    Fingerprint

    Methylphenidate
    Attention Deficit Disorder with Hyperactivity
    Pharmaceutical Preparations
    Placebos
    Neuropsychological Tests
    Cross-Over Studies

    Keywords

    • Adolescent
    • Association Learning
    • Attention Deficit Disorder with Hyperactivity
    • Central Nervous System Stimulants
    • Child
    • Choice Behavior
    • Cross-Over Studies
    • Dose-Response Relationship, Drug
    • Double-Blind Method
    • Drug Administration Routes
    • Humans
    • Male
    • Methylphenidate
    • Neuropsychological Tests
    • Predictive Value of Tests
    • Principal Component Analysis
    • Problem Solving
    • Reaction Time
    • Recognition (Psychology)
    • Time Factors

    Cite this

    @article{c748aa40699c4f17a9a5d5d869fcc826,
    title = "The neuropsychological effects of chronic methylphenidate on drug-naive boys with attention-deficit/hyperactivity disorder",
    abstract = "Background: The reported neuropsychological effects of methylphenidate (MPH) in attention-de ficit/hyperactivity disorder (ADHD) are inconsistent. The assumed relationships between these neuropsychological effects and clinical efficacy have not been substantiated. We therefore investigated the effects of chronic MPH administration on neuropsychological functioning. Methods: We conducted a 12-week, placebo-controlled, double-blinded, randomized, crossover trial (MPH .3 and .6 mg/kg/dose and placebo). Participants were 75 boys aged 7–15 years with ADHD. Neuropsychological performance was assessed with tests taken from the Cambridge Neuropsychological Test Automated Battery (CANTAB) battery and a GoNoGo task. Results: ChronicMPHimproved performance (p<.001) on aspects of theGoNoGotask (p<.02) and on threeCANTABtasks which together contributed to a “recognition memory” component identified through principal components analysis (delayed matching to sample [DMtS], Pattern and spatial recognition). There were no effects on other, high or low “executive demand” tasks (p>.05). GoNoGo performance improvements were the only neuropsychopharmacological changes associated with clinical response. Poor performance on the DMtS task was the sole baseline neuropsychological predictor of clinical response. Conclusions: Chronic MPH predominantly enhanced neuropsychological functioning on “recognition memory” component tasks with modest “executive” demands. Neuropsychological measures offer only modest contributions to the prediction of clinical responses to MPH in ADHD.",
    keywords = "Adolescent, Association Learning, Attention Deficit Disorder with Hyperactivity, Central Nervous System Stimulants, Child, Choice Behavior, Cross-Over Studies, Dose-Response Relationship, Drug, Double-Blind Method, Drug Administration Routes, Humans, Male, Methylphenidate, Neuropsychological Tests, Predictive Value of Tests, Principal Component Analysis, Problem Solving, Reaction Time, Recognition (Psychology), Time Factors",
    author = "Coghill, {David R.} and Rhodes, {Sinead M.} and Keith Matthews",
    note = "dc.publisher: Elsevier dc.description.sponsorship: TENOVUS - Scotland Eli Lilly Janssen Cilag Glaxo Smith Kline Cyberonics Inc.",
    year = "2007",
    month = "11",
    doi = "10.1016/j.biopsych.2006.12.030",
    language = "English",
    volume = "62",
    pages = "954--962",
    journal = "Biological Psychiatry",
    issn = "0006-3223",
    publisher = "Elsevier",
    number = "9",

    }

    The neuropsychological effects of chronic methylphenidate on drug-naive boys with attention-deficit/hyperactivity disorder. / Coghill, David R.; Rhodes, Sinead M.; Matthews, Keith.

    In: Biological Psychiatry, Vol. 62, No. 9, 11.2007, p. 954-962.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - The neuropsychological effects of chronic methylphenidate on drug-naive boys with attention-deficit/hyperactivity disorder

    AU - Coghill, David R.

    AU - Rhodes, Sinead M.

    AU - Matthews, Keith

    N1 - dc.publisher: Elsevier dc.description.sponsorship: TENOVUS - Scotland Eli Lilly Janssen Cilag Glaxo Smith Kline Cyberonics Inc.

    PY - 2007/11

    Y1 - 2007/11

    N2 - Background: The reported neuropsychological effects of methylphenidate (MPH) in attention-de ficit/hyperactivity disorder (ADHD) are inconsistent. The assumed relationships between these neuropsychological effects and clinical efficacy have not been substantiated. We therefore investigated the effects of chronic MPH administration on neuropsychological functioning. Methods: We conducted a 12-week, placebo-controlled, double-blinded, randomized, crossover trial (MPH .3 and .6 mg/kg/dose and placebo). Participants were 75 boys aged 7–15 years with ADHD. Neuropsychological performance was assessed with tests taken from the Cambridge Neuropsychological Test Automated Battery (CANTAB) battery and a GoNoGo task. Results: ChronicMPHimproved performance (p<.001) on aspects of theGoNoGotask (p<.02) and on threeCANTABtasks which together contributed to a “recognition memory” component identified through principal components analysis (delayed matching to sample [DMtS], Pattern and spatial recognition). There were no effects on other, high or low “executive demand” tasks (p>.05). GoNoGo performance improvements were the only neuropsychopharmacological changes associated with clinical response. Poor performance on the DMtS task was the sole baseline neuropsychological predictor of clinical response. Conclusions: Chronic MPH predominantly enhanced neuropsychological functioning on “recognition memory” component tasks with modest “executive” demands. Neuropsychological measures offer only modest contributions to the prediction of clinical responses to MPH in ADHD.

    AB - Background: The reported neuropsychological effects of methylphenidate (MPH) in attention-de ficit/hyperactivity disorder (ADHD) are inconsistent. The assumed relationships between these neuropsychological effects and clinical efficacy have not been substantiated. We therefore investigated the effects of chronic MPH administration on neuropsychological functioning. Methods: We conducted a 12-week, placebo-controlled, double-blinded, randomized, crossover trial (MPH .3 and .6 mg/kg/dose and placebo). Participants were 75 boys aged 7–15 years with ADHD. Neuropsychological performance was assessed with tests taken from the Cambridge Neuropsychological Test Automated Battery (CANTAB) battery and a GoNoGo task. Results: ChronicMPHimproved performance (p<.001) on aspects of theGoNoGotask (p<.02) and on threeCANTABtasks which together contributed to a “recognition memory” component identified through principal components analysis (delayed matching to sample [DMtS], Pattern and spatial recognition). There were no effects on other, high or low “executive demand” tasks (p>.05). GoNoGo performance improvements were the only neuropsychopharmacological changes associated with clinical response. Poor performance on the DMtS task was the sole baseline neuropsychological predictor of clinical response. Conclusions: Chronic MPH predominantly enhanced neuropsychological functioning on “recognition memory” component tasks with modest “executive” demands. Neuropsychological measures offer only modest contributions to the prediction of clinical responses to MPH in ADHD.

    KW - Adolescent

    KW - Association Learning

    KW - Attention Deficit Disorder with Hyperactivity

    KW - Central Nervous System Stimulants

    KW - Child

    KW - Choice Behavior

    KW - Cross-Over Studies

    KW - Dose-Response Relationship, Drug

    KW - Double-Blind Method

    KW - Drug Administration Routes

    KW - Humans

    KW - Male

    KW - Methylphenidate

    KW - Neuropsychological Tests

    KW - Predictive Value of Tests

    KW - Principal Component Analysis

    KW - Problem Solving

    KW - Reaction Time

    KW - Recognition (Psychology)

    KW - Time Factors

    U2 - 10.1016/j.biopsych.2006.12.030

    DO - 10.1016/j.biopsych.2006.12.030

    M3 - Article

    C2 - 17543895

    VL - 62

    SP - 954

    EP - 962

    JO - Biological Psychiatry

    JF - Biological Psychiatry

    SN - 0006-3223

    IS - 9

    ER -