The non-mevalonate pathway of isoprenoid precursor biosynthesis

    Research output: Contribution to journalArticle

    223 Citations (Scopus)

    Abstract

    The recently discovered non-mevalonate biosynthetic route to isoprenoid precursors is an essential metabolic pathway in plants, apicomplexan parasites, and many species of bacteria. The pathway relies on eight enzymes exploiting different cofactors and metal ions. Structural and mechanistic data now exist for most components of the pathway though there remain some gaps in our knowledge. The individual enzymes represent new, validated targets for broad spectrum antimicrobial drug and herbicide development. Detailed knowledge of the pathway may also be exploited to genetically modify microorganisms and plants to produce compounds of agricultural and medical interest.
    Original languageEnglish
    Pages (from-to)21573-21577
    Number of pages5
    JournalJournal of Biological Chemistry
    Volume282
    Issue number30
    DOIs
    Publication statusPublished - 2007

    Fingerprint

    Biosynthesis
    Terpenes
    Herbicides
    Enzymes
    Metabolic Networks and Pathways
    Microorganisms
    Metal ions
    Bacteria
    Parasites
    Metals
    Ions
    Pharmaceutical Preparations

    Keywords

    • Aldose-Ketose Isomerases
    • Animals
    • Apicomplexa
    • Bacteria
    • Carbon-Carbon Double Bond Isomerases
    • Mevalonic Acid
    • Multienzyme Complexes
    • Nucleotidyltransferases
    • Oxidoreductases
    • Phosphotransferases (Alcohol Group Acceptor)
    • Plants
    • Terpenes
    • Transferases

    Cite this

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    title = "The non-mevalonate pathway of isoprenoid precursor biosynthesis",
    abstract = "The recently discovered non-mevalonate biosynthetic route to isoprenoid precursors is an essential metabolic pathway in plants, apicomplexan parasites, and many species of bacteria. The pathway relies on eight enzymes exploiting different cofactors and metal ions. Structural and mechanistic data now exist for most components of the pathway though there remain some gaps in our knowledge. The individual enzymes represent new, validated targets for broad spectrum antimicrobial drug and herbicide development. Detailed knowledge of the pathway may also be exploited to genetically modify microorganisms and plants to produce compounds of agricultural and medical interest.",
    keywords = "Aldose-Ketose Isomerases, Animals, Apicomplexa, Bacteria, Carbon-Carbon Double Bond Isomerases, Mevalonic Acid, Multienzyme Complexes, Nucleotidyltransferases, Oxidoreductases, Phosphotransferases (Alcohol Group Acceptor), Plants, Terpenes, Transferases",
    author = "Hunter, {William N.}",
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    language = "English",
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    pages = "21573--21577",
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    publisher = "American Society for Biochemistry and Molecular Biology",
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    }

    The non-mevalonate pathway of isoprenoid precursor biosynthesis. / Hunter, William N.

    In: Journal of Biological Chemistry, Vol. 282, No. 30, 2007, p. 21573-21577.

    Research output: Contribution to journalArticle

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    AU - Hunter, William N.

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    KW - Animals

    KW - Apicomplexa

    KW - Bacteria

    KW - Carbon-Carbon Double Bond Isomerases

    KW - Mevalonic Acid

    KW - Multienzyme Complexes

    KW - Nucleotidyltransferases

    KW - Oxidoreductases

    KW - Phosphotransferases (Alcohol Group Acceptor)

    KW - Plants

    KW - Terpenes

    KW - Transferases

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