Too much, too little or just enough

a Goldilocks effect for IL-13 and skin barrier regulation?

Jessica Strid (Lead / Corresponding author), W. H. Irwin McLean, Alan D. Irvine (Lead / Corresponding author)

Research output: Contribution to journalComment/debate

2 Citations (Scopus)

Abstract

The mechanistic relationship between IL-4/IL-13 and skin barrier function has been of interest since the filaggrin discovery and the subsequent in vitro demonstration that IL-4 and IL-13 downregulate filaggrin expression in cultured keratinocytes. Hönzke and colleagues explore these interactions further. The effects of IL-4/ll-13 may be context dependent, with differing roles in homeostasis and in disease.

Original languageEnglish
Pages (from-to)561-564
Number of pages4
JournalJournal of Investigative Dermatology
Volume136
Issue number3
Early online date19 Feb 2016
DOIs
Publication statusPublished - Mar 2016

Fingerprint

Interleukin-13
Interleukin-4
Skin
Keratinocytes
Homeostasis
Demonstrations
Down-Regulation
filaggrin

Keywords

  • Cytokines
  • Dermatitis, Atopic
  • Humans
  • Intermediate filament proteins
  • Tight junction proteins
  • beta-defensins
  • Comment
  • Journal article

Cite this

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title = "Too much, too little or just enough: a Goldilocks effect for IL-13 and skin barrier regulation?",
abstract = "The mechanistic relationship between IL-4/IL-13 and skin barrier function has been of interest since the filaggrin discovery and the subsequent in vitro demonstration that IL-4 and IL-13 downregulate filaggrin expression in cultured keratinocytes. H{\"o}nzke and colleagues explore these interactions further. The effects of IL-4/ll-13 may be context dependent, with differing roles in homeostasis and in disease.",
keywords = "Cytokines, Dermatitis, Atopic, Humans, Intermediate filament proteins, Tight junction proteins, beta-defensins, Comment, Journal article",
author = "Jessica Strid and McLean, {W. H. Irwin} and Irvine, {Alan D.}",
note = "Copyright {\circledC} 2015 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2016",
month = "3",
doi = "10.1016/j.jid.2015.12.025",
language = "English",
volume = "136",
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journal = "Journal of Investigative Dermatology",
issn = "0022-202X",
publisher = "Nature Publishing Group",
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Too much, too little or just enough : a Goldilocks effect for IL-13 and skin barrier regulation? / Strid, Jessica (Lead / Corresponding author); McLean, W. H. Irwin; Irvine, Alan D. (Lead / Corresponding author).

In: Journal of Investigative Dermatology, Vol. 136, No. 3, 03.2016, p. 561-564.

Research output: Contribution to journalComment/debate

TY - JOUR

T1 - Too much, too little or just enough

T2 - a Goldilocks effect for IL-13 and skin barrier regulation?

AU - Strid, Jessica

AU - McLean, W. H. Irwin

AU - Irvine, Alan D.

N1 - Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2016/3

Y1 - 2016/3

N2 - The mechanistic relationship between IL-4/IL-13 and skin barrier function has been of interest since the filaggrin discovery and the subsequent in vitro demonstration that IL-4 and IL-13 downregulate filaggrin expression in cultured keratinocytes. Hönzke and colleagues explore these interactions further. The effects of IL-4/ll-13 may be context dependent, with differing roles in homeostasis and in disease.

AB - The mechanistic relationship between IL-4/IL-13 and skin barrier function has been of interest since the filaggrin discovery and the subsequent in vitro demonstration that IL-4 and IL-13 downregulate filaggrin expression in cultured keratinocytes. Hönzke and colleagues explore these interactions further. The effects of IL-4/ll-13 may be context dependent, with differing roles in homeostasis and in disease.

KW - Cytokines

KW - Dermatitis, Atopic

KW - Humans

KW - Intermediate filament proteins

KW - Tight junction proteins

KW - beta-defensins

KW - Comment

KW - Journal article

U2 - 10.1016/j.jid.2015.12.025

DO - 10.1016/j.jid.2015.12.025

M3 - Comment/debate

VL - 136

SP - 561

EP - 564

JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

SN - 0022-202X

IS - 3

ER -