Topical methyl aminolaevulinate photodynamic therapy versus cryotherapy for superficial basal cell carcinoma: a 5 year randomized trial

Nicole Basset-Seguin, Sally H. Ibbotson, Lennart Emtestam, Mikael Tarstedt, Colin Morton, Marianne Maroti, Piergiacomo Calzavara-Pinton, Sandeep Varma, Rik Roelandts, Peter Wolf

    Research output: Contribution to journalArticle

    153 Citations (Scopus)

    Abstract

    This multicentre, randomized study compared photodynamic therapy using topical methyl aminolaevulinate (MAL PDT), a non-invasive modality, with cryotherapy for treatment of superficial basal cell carcinoma. Sixty patients with 114 lesions were treated with MAL cream (160 mg/g) applied for 3 hours before illumination (570-670 nm, light dose 75 J/cm) (I session), and 58 with 105 lesions received cryotherapy (2 freeze-thaw cycles). Patients with an incomplete response at 3 months received 2 further MAL PDT sessions (n = 20) or repeat cryotherapy (n = 16). 100 lesions treated with MAL PDT and 93 lesions treated with cryotherapy were in complete response at 3 months after the last treatment and evaluable for recurrence over 5 years. There was no difference in 5-year recurrence rates with either treatment (20% with cryotherapy vs. 22% with MAL PDT, p = 0.86). However, more patients had an excellent cosmetic outcome with MAL PDT (60% vs. 16% with cryotherapy, p = 0.00078). These results provide support for the use of MAL PDT as a non-invasive, selective treatment alternative for primary superficial basal cell carcinoma.

    Original languageEnglish
    Pages (from-to)547-553
    Number of pages7
    JournalEuropean Journal of Dermatology
    Volume18
    Issue number5
    Publication statusPublished - 2008

    Keywords

    • methyl aminolaevulinate
    • photodynamic therapy
    • superficial basal cell carcinoma
    • FOLLOW-UP
    • GUIDELINES
    • CANCER
    • AGE
    • CRYOSURGERY
    • MANAGEMENT
    • RECURRENCE
    • SKIN

    Cite this

    Basset-Seguin, Nicole ; Ibbotson, Sally H. ; Emtestam, Lennart ; Tarstedt, Mikael ; Morton, Colin ; Maroti, Marianne ; Calzavara-Pinton, Piergiacomo ; Varma, Sandeep ; Roelandts, Rik ; Wolf, Peter. / Topical methyl aminolaevulinate photodynamic therapy versus cryotherapy for superficial basal cell carcinoma: a 5 year randomized trial. In: European Journal of Dermatology. 2008 ; Vol. 18, No. 5. pp. 547-553.
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    abstract = "This multicentre, randomized study compared photodynamic therapy using topical methyl aminolaevulinate (MAL PDT), a non-invasive modality, with cryotherapy for treatment of superficial basal cell carcinoma. Sixty patients with 114 lesions were treated with MAL cream (160 mg/g) applied for 3 hours before illumination (570-670 nm, light dose 75 J/cm) (I session), and 58 with 105 lesions received cryotherapy (2 freeze-thaw cycles). Patients with an incomplete response at 3 months received 2 further MAL PDT sessions (n = 20) or repeat cryotherapy (n = 16). 100 lesions treated with MAL PDT and 93 lesions treated with cryotherapy were in complete response at 3 months after the last treatment and evaluable for recurrence over 5 years. There was no difference in 5-year recurrence rates with either treatment (20{\%} with cryotherapy vs. 22{\%} with MAL PDT, p = 0.86). However, more patients had an excellent cosmetic outcome with MAL PDT (60{\%} vs. 16{\%} with cryotherapy, p = 0.00078). These results provide support for the use of MAL PDT as a non-invasive, selective treatment alternative for primary superficial basal cell carcinoma.",
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    author = "Nicole Basset-Seguin and Ibbotson, {Sally H.} and Lennart Emtestam and Mikael Tarstedt and Colin Morton and Marianne Maroti and Piergiacomo Calzavara-Pinton and Sandeep Varma and Rik Roelandts and Peter Wolf",
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    Basset-Seguin, N, Ibbotson, SH, Emtestam, L, Tarstedt, M, Morton, C, Maroti, M, Calzavara-Pinton, P, Varma, S, Roelandts, R & Wolf, P 2008, 'Topical methyl aminolaevulinate photodynamic therapy versus cryotherapy for superficial basal cell carcinoma: a 5 year randomized trial', European Journal of Dermatology, vol. 18, no. 5, pp. 547-553.

    Topical methyl aminolaevulinate photodynamic therapy versus cryotherapy for superficial basal cell carcinoma: a 5 year randomized trial. / Basset-Seguin, Nicole; Ibbotson, Sally H.; Emtestam, Lennart; Tarstedt, Mikael; Morton, Colin; Maroti, Marianne; Calzavara-Pinton, Piergiacomo; Varma, Sandeep; Roelandts, Rik; Wolf, Peter.

    In: European Journal of Dermatology, Vol. 18, No. 5, 2008, p. 547-553.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Topical methyl aminolaevulinate photodynamic therapy versus cryotherapy for superficial basal cell carcinoma: a 5 year randomized trial

    AU - Basset-Seguin, Nicole

    AU - Ibbotson, Sally H.

    AU - Emtestam, Lennart

    AU - Tarstedt, Mikael

    AU - Morton, Colin

    AU - Maroti, Marianne

    AU - Calzavara-Pinton, Piergiacomo

    AU - Varma, Sandeep

    AU - Roelandts, Rik

    AU - Wolf, Peter

    PY - 2008

    Y1 - 2008

    N2 - This multicentre, randomized study compared photodynamic therapy using topical methyl aminolaevulinate (MAL PDT), a non-invasive modality, with cryotherapy for treatment of superficial basal cell carcinoma. Sixty patients with 114 lesions were treated with MAL cream (160 mg/g) applied for 3 hours before illumination (570-670 nm, light dose 75 J/cm) (I session), and 58 with 105 lesions received cryotherapy (2 freeze-thaw cycles). Patients with an incomplete response at 3 months received 2 further MAL PDT sessions (n = 20) or repeat cryotherapy (n = 16). 100 lesions treated with MAL PDT and 93 lesions treated with cryotherapy were in complete response at 3 months after the last treatment and evaluable for recurrence over 5 years. There was no difference in 5-year recurrence rates with either treatment (20% with cryotherapy vs. 22% with MAL PDT, p = 0.86). However, more patients had an excellent cosmetic outcome with MAL PDT (60% vs. 16% with cryotherapy, p = 0.00078). These results provide support for the use of MAL PDT as a non-invasive, selective treatment alternative for primary superficial basal cell carcinoma.

    AB - This multicentre, randomized study compared photodynamic therapy using topical methyl aminolaevulinate (MAL PDT), a non-invasive modality, with cryotherapy for treatment of superficial basal cell carcinoma. Sixty patients with 114 lesions were treated with MAL cream (160 mg/g) applied for 3 hours before illumination (570-670 nm, light dose 75 J/cm) (I session), and 58 with 105 lesions received cryotherapy (2 freeze-thaw cycles). Patients with an incomplete response at 3 months received 2 further MAL PDT sessions (n = 20) or repeat cryotherapy (n = 16). 100 lesions treated with MAL PDT and 93 lesions treated with cryotherapy were in complete response at 3 months after the last treatment and evaluable for recurrence over 5 years. There was no difference in 5-year recurrence rates with either treatment (20% with cryotherapy vs. 22% with MAL PDT, p = 0.86). However, more patients had an excellent cosmetic outcome with MAL PDT (60% vs. 16% with cryotherapy, p = 0.00078). These results provide support for the use of MAL PDT as a non-invasive, selective treatment alternative for primary superficial basal cell carcinoma.

    KW - methyl aminolaevulinate

    KW - photodynamic therapy

    KW - superficial basal cell carcinoma

    KW - FOLLOW-UP

    KW - GUIDELINES

    KW - CANCER

    KW - AGE

    KW - CRYOSURGERY

    KW - MANAGEMENT

    KW - RECURRENCE

    KW - SKIN

    M3 - Article

    VL - 18

    SP - 547

    EP - 553

    JO - European Journal of Dermatology

    JF - European Journal of Dermatology

    SN - 1167-1122

    IS - 5

    ER -